Age-dependent survival, stress defense, and AMPK in Daphnia pulex after short-term exposure to a polystyrene nanoplastic

Liu, Zhiquan; Cai, Mingqi; Yu, Ping; Chen, Minghai; Wu, Donglei; Zhang, Meng; Zhao, Yunlong

doi:10.1016/j.aquatox.2018.08.017

Cited by 128 publications

(40 citation statements)

References 66 publications

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“…Thus, age must be considered as a factor of great relevance when predicting toxic effects. 84 Effects of nanoplastic on the innate immune system of fish have been reported by Greven et al, indicating that the stress response to polystyrene and polycarbonate nanoparticles could stimulate the degranulation of primary granules, oxidative burst activity, and neutrophil extracellular trap release. 85 Experiments with zebrafish revealed that after 7 days of exposure to fluorescent polystyrene nanoparticles with a diameter of 70 nm and at concentrations between 0.025 and 0.2 μg/μL, inflammation and lipid accumulation in the liver occurred.…”

Section: Sources and Fate Of Plastic In The Environmentmentioning

confidence: 90%

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Lehner

Weder

Petri‐Fink

et al. 2019

Environ. Sci. Technol.

837

364

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On account of environmental concerns, the fate and adverse effects of plastics have attracted considerable interest in the past few years. Recent studies have indicated the potential for fragmentation of plastic materials into nanoparticles, i.e., "nanoplastics," and their possible accumulation in the environment. Nanoparticles can show markedly different chemical and physical properties than their bulk material form. Therefore possible risks and hazards to the environment need to be considered and addressed. However, the fate and effect of nanoplastics in the (aquatic) environment has so far been little explored. In this review, we aim to provide an overview of the literature on this emerging topic, with an emphasis on the reported impacts of nanoplastics on human health, including the challenges involved in detecting plastics in a biological environment. We first discuss the possible sources of nanoplastics and their fates and effects in the environment and then describe the possible entry routes of these particles into the human body, as well as their uptake mechanisms at the cellular level. Since the potential risks of environmental nanoplastics to humans have not yet been extensively studied, we focus on studies demonstrating cell responses induced by polystyrene nanoparticles. In particular, the influence of particle size and surface chemistry are discussed, in order to understand the possible risks of nanoplastics for humans and provide recommendations for future studies.

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Section: Sources and Fate Of Plastic In The Environmentmentioning

confidence: 90%

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Lehner

Weder

Petri‐Fink

et al. 2019

Environ. Sci. Technol.

837

364

View full text Add to dashboard Cite

show abstract

“…Stresses at the PM and the endo-lysosomes would trigger cellular stress responses. In work done with species of the fresh water flea Daphnia, PS NPs exposure affected growth and reproduction [128], and interestingly resulted in the elevation of AMP activated protein kinase (AMPK), which is an indication of stress response [129]. Perhaps a more general associated phenomenon with regards to cellular stress response appears to be the production of ROS, which was in fact recently identified as the molecular initiating event (MIE) by adverse outcome pathways analysis of reports in the field [130].…”

Section: Mechanisms Underlying Mps/nps' Acute or Chronic Toxicity In mentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

521

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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“…Evidence of the availability and contamination impacts of such chemicals has been highlighted by many researchers. The adverse effects of microplastics on fishes and large aquatic animals, zooplankton, phytoplankton, microalgae, crustaceans, and seabirds have been widely reported (Boerger et al, 2010;Kögel et al, 2019;Ma et al, 2020;Corinaldesi et al, 2021;Wang et al, 2021), at the population levels (e.g., fertility, mortality, growth and organismal development, feeding activity) (Zarfl et al, 2011;Sussarellu et al, 2016;Heindler et al, 2017;Mouchi et al, 2019;Chapron et al, 2020;Liu G. et al, 2020;Issac and Kandasubramanian, 2021), cellular (e.g., motility; cell fragmentation, membrane stability, apoptosis) (Von Moos et al, 2012;Han et al, 2020;Tallec et al, 2020), and molecular levels (e.g., mortality, gene expression, stress defense, and oxidative stress effects) (Balbi et al, 2017;Liu Z et al, 2018;Yu et al, 2018;Sendra et al, 2020;Capolupo et al, 2021). Corals readily ingest polypropylene microplastics upon exposure to plastic particles, resulting in a variety of biological implications ranging from feeding dysfunction to mucus formation and distorted gene expression (Corinaldesi et al, 2021).…”

Section: Prevalence and Impacts Of Micro (Nano) Plastics In The Environmentmentioning

confidence: 99%

Physisorption and Chemisorption Mechanisms Influencing Micro (Nano) Plastics-Organic Chemical Contaminants Interactions: A Review

Agboola

Benson

2021

Front. Environ. Sci.

121

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Microplastics, which serve as sources and vector transport of organic contaminants in both terrestrial and marine environments, are emerging micropollutants of increasing concerns due to their potential harmful impacts on the environment, biota and human health. Microplastic particles have a higher affinity for hydrophobic organic contaminants due to their high surface area-to-volume ratio, particularly in aqueous conditions. However, recent findings have shown that the concentrations of organic contaminants adsorbed on microplastic surfaces, as well as their fate through vector distribution and ecological risks, are largely influenced by prevailing environmental factors and physicochemical properties in the aquatic environment. Therefore, this review article draws on scientific literature to discuss inherent polymers typically used in plastics and their affinity for different organic contaminants, as well as the compositions, environmental factors, and polymeric properties that influence their variability in sorption capacities. Some of the specific points discussed are (a) an appraisal of microplastic types, composition and their fate and vector transport in the environment; (b) a critical assessment of sorption mechanisms and major polymeric factors influencing organic contaminants-micro (nano) plastics (MNPs) interactions; (c) an evaluation of the sorption capacities of organic chemical contaminants to MNPs in terms of polymeric sorption characteristics including hydrophobicity, Van der Waals forces, π–π bond, electrostatic, and hydrogen bond interactions; and (d) an overview of the sorption mechanisms and dynamics behind microplastics-organic contaminants interactions using kinetic and isothermal models. Furthermore, insights into future areas of research gaps have been highlighted.

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Age-dependent survival, stress defense, and AMPK in Daphnia pulex after short-term exposure to a polystyrene nanoplastic

Cited by 128 publications

References 66 publications

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Physisorption and Chemisorption Mechanisms Influencing Micro (Nano) Plastics-Organic Chemical Contaminants Interactions: A Review

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