2014
DOI: 10.18632/aging.100692 View full text |Buy / Rent full text
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Abstract: Two classes of short RNAs have been identified as sequence-specific posttranscriptional regulators of gene expression, acting via RNA-induced silencing complexes (RISCs). They are termed small interfering RNAs (siRNAs) and microRNAs (miRNAs). Despite initial discovery from unrelated studies, these RNA classes are related in their biogenesis and assembly into RISC RNA-protein complexes, and are able to regulate gene transcripts negatively in diverse eukaryotes (Ambros, Nature, 2004, 431:350-355; Bartel, Cell, … Show more

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“…What’s more, study has indicated that loss of lncRNAs function leads to neural disease [ 11 ]. However, miRNAs, which are approximately 20–24 nucleotides in length, regulate gene expression post-transcriptionally by interacting with the 3′ untranslated region (3′-UTR) of target genes [ 12 ]. miRNAs play roles in energy homeostasis, especially the regulation of intestinal homeostasis, cell migration, cell cycle, cell apoptosis, cell proliferation, and neuronal function [ 13 15 ].…”
Section: Introductionmentioning
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“…What’s more, study has indicated that loss of lncRNAs function leads to neural disease [ 11 ]. However, miRNAs, which are approximately 20–24 nucleotides in length, regulate gene expression post-transcriptionally by interacting with the 3′ untranslated region (3′-UTR) of target genes [ 12 ]. miRNAs play roles in energy homeostasis, especially the regulation of intestinal homeostasis, cell migration, cell cycle, cell apoptosis, cell proliferation, and neuronal function [ 13 15 ].…”
Section: Introductionmentioning
“…The biding sites of miR-593-3p on LINC02163 were indicated in Figure 4A. MiRNAs exerted their gene silencing functions through a ribonucleoprotein complex, which was called the RNA-induced silencing complex (RISC), the core component of which was Ago2 [21]. RIP assay was performed to examine whether LINC02163 and miR-593-3p were in the same RISC complex.…”
Section: Lncrna Linc02163 Acted As Cerna To Regulate 4786 Expressionmentioning
“…5,6 The well-known miRNAs, which are approximately 20-24 nucleotides in length, are important posttranscriptional regulators that directly bind to the 3 0 -untranslated region (3 0 -UTR) of target genes. 7 Dysregulation of miRNAs has been robustly implicated in human cancer tumorigenesis and progression. [8][9][10] More recently, miR-101 was reported to be downregulated in several types of malignancy and functioned as a tumor suppressor in tumors, including those of breast cancer.…”
Section: Introductionmentioning