Age-dependent patterns of microRNA RISC loading

Grigoriev, Andrey; Bonini, Nancy M.

doi:10.18632/aging.100692

Cited by 14 publications

(10 citation statements)

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“…What’s more, study has indicated that loss of lncRNAs function leads to neural disease [ 11 ]. However, miRNAs, which are approximately 20–24 nucleotides in length, regulate gene expression post-transcriptionally by interacting with the 3′ untranslated region (3′-UTR) of target genes [ 12 ]. miRNAs play roles in energy homeostasis, especially the regulation of intestinal homeostasis, cell migration, cell cycle, cell apoptosis, cell proliferation, and neuronal function [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of lncRNA MEG3 and miR-770-5p inhibit cell migration and proliferation in Hirschsprung’s disease

Zhu

et al. 2017

Oncotarget

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The long noncoding RNA (lncRNA) MEG3 is involved in various biological processes including cell migration and cell proliferation. In present study, it was found that MEG3 and the intronic miR-770-5p were decreased in samples from HSCR patients. Besides, knockdown of MEG3 and miR-770-5p suppressed cell migration and proliferation, while cell cycle and apoptosis were not affected in human 293T and SH-SY5Y cells. SRGAP1 mRNA and protein upregulation was inversely correlated with miR-770-5p expression in tissue samples and cell lines, which was confirmed to be a target gene of miR-770-5p by dual-luciferase reporter assay. Moreover, silencing of SRGAP1 rescued the inhibition of cell migration and proliferation induced by MEG3 siRNA and miR-770-5p inhibition. The present study elucidates a novel mechanism of the development of HSCR and shows that the MEG3/miR-770-5p/SRGAP1 pathway plays a vital role in the pathogenesis of HSCR.

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“…The biding sites of miR-593-3p on LINC02163 were indicated in Figure 4A. MiRNAs exerted their gene silencing functions through a ribonucleoprotein complex, which was called the RNA-induced silencing complex (RISC), the core component of which was Ago2 [21]. RIP assay was performed to examine whether LINC02163 and miR-593-3p were in the same RISC complex.…”

Section: Lncrna Linc02163 Acted As Cerna To Regulate 4786 Expressionmentioning

confidence: 99%

LINC02163 regulates growth and epithelial-to-mesenchymal transition phenotype via miR-593-3p/FOXK1 axis in gastric cancer cells

Dong

Hong

Chen

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Recently, long non-coding RNAs (lncRNAs) were involved in promoting gastric cancer (GC) initiation and progression. In the current study, we revealed that the expression level of LINC02163 was elevated in GC cell lines and tissues. Knockdown of LINC02163 inhibited GC cells growth and invasion both in vitro and in vivo. Mechanismly, LINC02163 exerted as a ceRNA and negatively regulated miR-593-3p expression. In addition, FOXK1 was identified as a down-stream target of miR-593-3p. The miR-593-3p/FOXK1 axis mediated LINC02163's effect on GC. To the best of our knowledge, our findings provided the first evidence that LINC02163 functioned as an oncogene in GC. LINC02163 may be a candidate prognostic biomarker and a target for new therapies in GC patients.

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“…5,6 The well-known miRNAs, which are approximately 20-24 nucleotides in length, are important posttranscriptional regulators that directly bind to the 3 0 -untranslated region (3 0 -UTR) of target genes. 7 Dysregulation of miRNAs has been robustly implicated in human cancer tumorigenesis and progression. [8][9][10] More recently, miR-101 was reported to be downregulated in several types of malignancy and functioned as a tumor suppressor in tumors, including those of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Retracted Article: SNHG3 promotes proliferation and invasion by regulating the miR-101/ZEB1 axis in breast cancer

Chang

Zhou

et al. 2018

RSC Adv.

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“…The binding sites of miR‐298 on LINC01287 were indicated in Figure A. MiRNAs directed their downstream targets through a ribonucleoprotein complex, which was called the RNA‐induced silencing complex (RISC), the core component of which was Ago2 . RNA immunoprecipitation (RIP) assay was performed to examine whether LINC01287 and miR‐298 were in the same RISC complex.…”

Section: Resultsmentioning

confidence: 99%

LINC01287 regulates tumorigenesis and invasion via miR‐298/MYB in hepatocellular carcinoma

Lai

et al. 2018

J Cellular Molecular Medi

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Recently, it was reported that long non‐coding RNAs (lncRNAs) participated in promoting hepatocellular carcinoma (HCC) initiation and progression. Herein, we reported that the expression level of LINC01287 was elevated in HCC cell lines and tissues. LINC01287 down‐regulation inhibited HCC cells growth and invasion both in vitro and in vivo. LINC01287 exerted as a ceRNA and negatively regulated miR‐298 expression. MYB was identified as a downstream target of miR‐298. The miR‐298/MYB axis mediated LINC01287's effect on HCC. To the best of our knowledge, our findings provided the first evidence that LINC01287 functioned as an oncogene in HCC. LINC01287 may be a candidate prognostic biomarker and a target for new therapies in HCC patients.

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“…Several recent reviews offer comprehensive summaries of what is currently known about these molecules ( 18 , 21 – 23 ). In addition to human, tRFs have been reported in many other organisms, including mouse ( 3 ), fruit-fly ( 10 , 24 ), plants ( 4 ) and prokaryotes ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

Pliatsika

Loher

Magee

et al. 2017

Nucleic Acids Research

143

136

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MINTbase is a repository that comprises nuclear and mitochondrial tRNA-derived fragments (‘tRFs’) found in multiple human tissues. The original version of MINTbase comprised tRFs obtained from 768 transcriptomic datasets. We used our deterministic and exhaustive tRF mining pipeline to process all of The Cancer Genome Atlas datasets (TCGA). We identified 23 413 tRFs with abundance of ≥ 1.0 reads-per-million (RPM). To facilitate further studies of tRFs by the community, we just released version 2.0 of MINTbase that contains information about 26 531 distinct human tRFs from 11 719 human datasets as of October 2017. Key new elements include: the ability to filter tRFs on-the-fly by minimum abundance thresholding; the ability to filter tRFs by tissue keywords; easy access to information about a tRF’s maximum abundance and the datasets that contain it; the ability to generate relative abundance plots for tRFs across cancer types and convert them into embeddable figures; MODOMICS information about modifications of the parental tRNA, etc. Version 2.0 of MINTbase contains 15x more datasets and nearly 4x more distinct tRFs than the original version, yet continues to offer fast, interactive access to its contents. Version 2.0 is available freely at http://cm.jefferson.edu/MINTbase/.

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Age-dependent patterns of microRNA RISC loading

Cited by 14 publications

References 0 publications

Downregulation of lncRNA MEG3 and miR-770-5p inhibit cell migration and proliferation in Hirschsprung’s disease

LINC02163 regulates growth and epithelial-to-mesenchymal transition phenotype via miR-593-3p/FOXK1 axis in gastric cancer cells

Retracted Article: SNHG3 promotes proliferation and invasion by regulating the miR-101/ZEB1 axis in breast cancer

LINC01287 regulates tumorigenesis and invasion via miR‐298/MYB in hepatocellular carcinoma

MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

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