Age‐Dependent Impairment in Endothelial Function and Arterial Stiffness in Former High Class Male Athletes Is No Different to That in Men With No History of Physical Training

Majerczak, Joanna; Grandys, Marcin; Frołow, Marzena; Szkutnik, Zbigniew; Zakrzewska, Agnieszka; Niżankowski, Rafał; Duda, Krzysztof; Chłopicki, Stefan; Zoladz, Jerzy A.

doi:10.1161/jaha.119.012670

Cited by 27 publications

(36 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interactions between androgens and inflammation may be influenced by adipose tissue because it is well known that the inflammatory process results from an imbalance between the pro- and antioxidant systems often related to dysfunctional adipose tissue ( 10 ). We have recently demonstrated that the BMI and body fat percentage correlated positively with the inflammatory and oxidative stress markers in men ( 11 ), which could explain the age-related increase in inflammation and oxidative stress that led to a decline in endothelial function and an increase in arterial stiffness. In addition, Bobjer et al.…”

Section: Introductionmentioning

confidence: 99%

Lowered Serum Testosterone Concentration Is Associated With Enhanced Inflammation and Worsened Lipid Profile in Men

et al. 2021

Self Cite

View full text Add to dashboard Cite

The negative relationship between testosterone and inflammatory cytokines has been reported for decades, although the exact mechanisms of their interactions are still not clear. At the same time, little is known about the relation between androgens and acute phase proteins. Therefore, in this investigation, we aimed to study the relationship between androgen status and inflammatory acute phase reactants in a group of men using multi-linear regression analysis. Venous blood samples were taken from 149 men ranging in age from 18 to 77 years. Gonadal androgens [testosterone (T) and free testosterone (fT)], acute phase reactants [C-reactive protein (CRP), ferritin (FER), alpha-1-acid glycoprotein (AAG), and interleukin-6 (IL-6)], cortisol (C), and lipid profile concentrations were determined. It was demonstrated that the markers of T and fT were negatively correlated with all acute phase proteins (CRP, FER, and AAG; p < 0.02) and the blood lipid profile [total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG); p < 0.03]. Multivariate analysis showed that T, fT, and the fT/C ratio were inversely correlated with the CRP, AAG, and FER concentrations independently of age and blood lipids. When adjustment for BMI was made, T, fT, and the fT/C ratio were negatively correlated with the AAG concentrations only. In addition, it was demonstrated that gonadal androgens were positively correlated with physical activity level (p < 0.01). We have concluded that a lowered serum T concentration may promote inflammatory processes independently of adipose tissue and age through a reduced inhibition of inflammatory cytokine synthesis, which leads to enhanced acute phase protein production. Therefore, a low serum T concentration appears to be an independent risk factor in the development of atherosclerosis and cardiovascular diseases. Moreover, the positive correlation between testosterone and physical activity level suggests that exercise training attenuates the age-related decrease in gonadal androgens and, in this way, may reduce the enhancement of systemic low-grade inflammation in aging men.

show abstract

Section: Introductionmentioning

confidence: 99%

Lowered Serum Testosterone Concentration Is Associated With Enhanced Inflammation and Worsened Lipid Profile in Men

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although serum sodium concentration is inversely associated with circulating CD34-positive cell levels among subjects without hypertension, no data were available for the evaluation of endothelial function. As aging is the main contributing factor to decline in endothelial function 44 , further analyses that include endothelial function-related data such as flow-mediated dilation (FMD) will be necessary. Unknown confounding factors such as medication status and duration of medication for hypertension, diabetes, dyslipidemia, inflammatory disease, and thyroid disease, could influence the present study.…”

Section: Discussionmentioning

confidence: 99%

Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study

Shimizu

Yamanashi

Fukui

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum sodium may be inversely associated with that of circulating CD34-positive cells, thus indicating the degree of age-related endothelial injury. We conducted a cross-sectional study of 246 elderly Japanese men aged 60–69 years. Subjects were stratified by hypertension status because hypertension should act as a strong confounding factor for the analyses performed in this study. Serum sodium concentration was positively associated with handgrip strength in non-hypertensive subjects [standardized parameter estimate (β) = 0.29; p = 0.003], but not for hypertensive subjects (β = 0.01; p = 0.878), while it was inversely associated with circulating CD34-positive cell levels in non-hypertensive subjects [simple correlation coefficient (r) = − 0.28; p = 0.002] but not for hypertensive subjects (r = − 0.07; p = 0.454). For non-hypertensive elderly subjects, serum sodium concentration within the normal range is positively associated with handgrip strength and inversely associated with CD34-positive cells, thus partly indicating the degree of age-related endothelium injury. These associations could prove to be an efficient tool for clarifying the background mechanism governing the decrease in age-related muscle strength.

show abstract

“…Majerczak and colleagues showed that both the amount of oxidative stress by lipid peroxidation and glycocalyx shedding by syndecan-1 and heparan sulfate release in circulation were significantly reduced, while the enzymatic antioxidative defence by superoxide dismutase (SOD) in muscle was increased after 20 weeks of moderate-intensity endurance training 13 . However, analysis of parameter relationships was not performed in the aforementioned study and recent reports stated no change of glycocalyx integrity with exercise training 14 or between moderately trained and untrained participants 15 .…”

Section: Introductionmentioning

confidence: 93%

Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

Kröpfl

Beltrami

Rehm

et al. 2021

Journal of Science and Medicine in Sport

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Age‐Dependent Impairment in Endothelial Function and Arterial Stiffness in Former High Class Male Athletes Is No Different to That in Men With No History of Physical Training

Cited by 27 publications

References 63 publications

Lowered Serum Testosterone Concentration Is Associated With Enhanced Inflammation and Worsened Lipid Profile in Men

Lowered Serum Testosterone Concentration Is Associated With Enhanced Inflammation and Worsened Lipid Profile in Men

Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study

Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

Contact Info

Product

Resources

About