2014
DOI: 10.18632/aging.100639 View full text |Buy / Rent full text
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Abstract: Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One mechanism through which mitochondrial dysfunction can be caused is through changes in mitochondrial morphology. To determine the role of mitochondrial morphology changes in age-dependent mitochondrial dysfunction, we studied mitochondrial morphology in body wall muscles of the nematode C. elegans. We found that in this tissue, animals display a tubular mitochondrial network, which fragments with increasing age. This fragm… Show more

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