2019
DOI: 10.1111/acel.12853
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Abstract: Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan, and clear age‐dependent physiological changes. Aged C. elegans display a decline in their anatomical and functional features, including tissue integrity, motility, learning and memory, and immunity. Caenorhabditis elegans also exhibit many age‐associated changes in the expression of microRNAs and stress‐responsive genes and in RNA and protein quality contr… Show more

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Cited by 108 publications
(66 citation statements)
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“…Caenorhabditis elegans exhibits many age-associated changes in gene expression, protein quality control systems, tissue integrity and immunity [19]. Individual features such as hsp-16.2 expression, pharyngeal pumping rate, maximum velocity (at day 9 of adulthood) or a combination of multiple features such as movement, auto-fluorescence, and body size were previously shown to correlate well with lifespan or to predict remaining life [4,6,11,20].…”
Section: Discussionmentioning
confidence: 99%
“…Caenorhabditis elegans exhibits many age-associated changes in gene expression, protein quality control systems, tissue integrity and immunity [19]. Individual features such as hsp-16.2 expression, pharyngeal pumping rate, maximum velocity (at day 9 of adulthood) or a combination of multiple features such as movement, auto-fluorescence, and body size were previously shown to correlate well with lifespan or to predict remaining life [4,6,11,20].…”
Section: Discussionmentioning
confidence: 99%
“…Since frailty is the most problematic expression of population aging, it is important to test whether antiaging compounds reduce severity of frailty and improve healthspan [28][29][30]. Therefore, we assessed the effects of verapamil on several age-related physiological parameters.…”
Section: Verapamil Extends Lifespan and Improves Healthspan In C Elementioning
confidence: 99%
“…The discovery of the first long‐lived mutant strain in Caenorhabditis elegans (Son, Altintas, Kim, Kwon, & Lee, ) was a breakthrough in aging research. This finding aimed to find appropriate means to extend the lifespan of eukaryotic species, from single‐celled yeast to humans.…”
Section: Introductionmentioning
confidence: 99%