Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan

Ohta, Akio; Nagai, Masaki; Nishina, Masami; Tomimitsu, Hiroyuki; Kohsaka, Hitoshi

doi:10.1007/s10165-012-0733-7

Cited by 22 publications

(24 citation statements)

References 4 publications

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“…These differences may have been caused by the stringent inclusion criteria in the present study. However, the gender ratio and age distribution, with the exception of the elderly population, were similar to those described in previous studies …”

Section: Discussionsupporting

confidence: 88%

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

et al. 2018

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“…Corticosteroids have long been associated with the risk of acquiring TB 27 28 29 . This may be because corticosteroids have profound effects on immunomodulation, including inhibition of macrophage function 30 , the induction of apoptosis in dendritic cells 31 and the suppression of T cell activation 32 . These complex effects may attenuate host immune responses and predispose patients to TB infection 27 .…”

Section: Discussionmentioning

confidence: 99%

The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study

Lin

Yang

et al. 2015

Sci Rep

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The risk of active tuberculosis (TB) in patients with dermatomyositis (DM) is poorly understood. The cohort study aimed to investigate the association between DM and the risk of active TB disease. We conducted a population based study on 4,958 patients with newly diagnosed DM and 19,832 matched controls according to age, sex, and index date between 1998 and 2008. The hazard ratios (HRs) and cumulative incidences of active TB disease between DM patients and controls were analyzed. During the study period, a total of 85 (1.7%) DM patients developed active TB disease, which was significantly higher than that of non-DM patients (0.64%). The incidence rate of active TB disease was higher among DM patients than controls (incidence rate ratio 2.95; 95% confidence interval [CI], 2.24 to 3.88). The Cox regression model demonstrated significantly higher active TB disease rate among DM patients compared with controls (adjusted HR, 2.64; 95% CI, 1.97 to 3.54; p < 0.001) after adjusting for age, sex, and underlying medical disorders. The most significant risk factors for developing active TB included male sex, diabetes mellitus comorbidity, and use of corticosteroids and azathioprine in DM patients. In conclusion, DM patients are at a greater risk for active TB disease.

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“…Predictors of mortality for polymyositis, dermatomyositis, and JDM have been determined and were found to be similar in different parts of the world and among phenotypes, with interstitial lung disease and the anti-synthetase autoantibodies among the risk factors predicting greater mortality [1**,37,67,82]. Classic epidemiologic investigations have been performed, deriving estimates of incidence and prevalence in national registries [3*,58], with documented increases in incidence over time for IBM in Australia and an increased prevalence of polymyositis and dermatomyositis in urban regions of Canada, for example [9,10*,97,129,138]. …”

Section: Research Advances Through Myositis Registries and Biorepositmentioning

confidence: 99%

“…Clinical registries include national administrative efforts and health care systems’ tracking of medical utilization, costs, and outcomes, including such databases as the Social Security Death Index, from which mortality information may be gleaned [1**;2] or national health care registration systems that can be used to estimate disease prevalence in epidemiologic research [3*]. Registries may also include those that involve investigator-initiated research, with data collection that may include epidemiology, clinical features, outcomes, disease activity and damage assessments, and assessment of responses to therapies.…”

Section: Introductionmentioning

confidence: 99%

Myositis registries and biorepositories

Rider¹,

Dankó²,

Miller³

2014

Current Opinion in Rheumatology

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Purpose of review Clinical registries and biorepositories have proven extremely useful in many studies of diseases, especially rare diseases. Given their rarity and diversity, the idiopathic inflammatory myopathies, or myositis syndromes, have benefited from individual researchers’ collections of cohorts of patients. Major efforts are being made to establish large registries and biorepositories that will allow many additional studies to be performed that were not possible before. Here we describe the registries developed by investigators and patient support groups that are currently available for collaborative research purposes. Recent findings We have identified 46 myositis research registries, including many with biorepositories, which have been developed for a wide variety of purposes and have resulted in great advances in understanding the range of phenotypes, clinical presentations, risk factors, pathogenic mechanisms, outcome assessment, therapeutic responses, and prognoses. These are now available for collaborative use to undertake additional studies. Two myositis patient registries have been developed for research, and myositis patient support groups maintain demographic registries with large numbers of patients available to be contacted for potential research participation. Summary Investigator-initiated myositis research registries and biorepositories have proven extremely useful in understanding many aspects of these rare and diverse autoimmune diseases. These registries and biorepositories, in addition to those developed by myositis patient support groups, deserve continued support to maintain the momentum in this field as they offer major opportunities to improve understanding of the pathogenesis and treatment of these diseases in cost-effective ways.

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Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan

Cited by 22 publications

References 4 publications

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study

Myositis registries and biorepositories

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