2013
DOI: 10.18632/aging.100622
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Abstract: Age is the greatest risk factor for cardiovascular disease. In addition, inflammation and age (senescence) have been linked at both the clinical and molecular levels. In general, senescent cells have been described as pro-inflammatory based on their senescence associated secretory phenotype (SASP). However, we have previously shown that senescence induced by overexpression of SENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype. We have investigated, at the individual cellular le… Show more

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Cited by 42 publications
(31 citation statements)
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References 40 publications
(47 reference statements)
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“…Oxidative stress and other stress factors are known to induce anti-inflammatory senescent phenotype in endothelial cells accompanied by reduced expression of the cell adhesion molecules [89]. The cell cycle arrest and anti-inflammatory phenotype was mediated by p38 MAPK [89, 90].…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress and other stress factors are known to induce anti-inflammatory senescent phenotype in endothelial cells accompanied by reduced expression of the cell adhesion molecules [89]. The cell cycle arrest and anti-inflammatory phenotype was mediated by p38 MAPK [89, 90].…”
Section: Discussionmentioning
confidence: 99%
“…However, the correlation between hypoxia and senescence is controversial. Coleman et al [34] demonstrated that severe hypoxic conditions (< 0.5% O 2 ) induced senescence in endothelial cells. In addition, hypoxia and the hypoxia-mimetic agent CoCl 2 can induce senescence by upregulating Bcl-2 in melanoma cells [35].…”
Section: Hypoxic Induction Of the Ink4a Gene Despite An Increase In Tmentioning
confidence: 99%
“…Endothelial dysfunction is associated with the pathogenesis of common diseases. Oxidative stress, hypoxia, and flow disturbances are important factors that are related to endothelial dysfunction (Coleman et al 2013).…”
Section: Introductionmentioning
confidence: 99%