volume 99, issue 4, P1876-1881 2002
DOI: 10.1073/pnas.261709098
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Abstract: We test whether the dysfunction with age of carnitine acetyltransferase (CAT), a key mitochondrial enzyme for fuel utilization, is due to decreased binding affinity for substrate and whether this substrate, fed to old rats, restores CAT activity. The kinetics of CAT were analyzed by using the brains of young and old rats and of old rats supplemented for 7 weeks with the CAT substrate acetyl-Lcarnitine (ALCAR) and͞or the mitochondrial antioxidant precursor R-␣-lipoic acid (LA). Old rats, compared with young ra…

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