volume 5, issue 9, P692-703 2013
DOI: 10.18632/aging.100598
View full text
Evi M. Mercken, Elisa Majounie, Jinhui Ding, Rong Guo, Jiyoung Kim, Michel Bernier, Julie Mattison, Mark R. Cookson, Myriam Gorospe, Rafael de Cabo, Kotb Abdelmohsen

Abstract: The levels of microRNAs (miRNAs) are altered under different conditions such as cancer, senescence, and aging. Here, we have identified differentially expressed miRNAs in skeletal muscle from young and old rhesus monkeys using RNA sequencing. In old muscle, several miRNAs were upregulated, including miR-451, miR-144, miR-18a and miR-15a, while a few miRNAs were downregulated, including miR-181a and miR-181b. A number of novel miRNAs were also identified, particularly in old muscle. We also examined the impact …

expand abstract