2013
DOI: 10.18632/aging.100598
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The levels of microRNAs (miRNAs) are altered under different conditions such as cancer, senescence, and aging. Here, we have identified differentially expressed miRNAs in skeletal muscle from young and old rhesus monkeys using RNA sequencing. In old muscle, several miRNAs were upregulated, including miR-451, miR-144, miR-18a and miR-15a, while a few miRNAs were downregulated, including miR-181a and miR-181b. A number of novel miRNAs were also identified, particularly in old muscle. We also examined the impact … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

3
85
1

Year Published

2014
2014
2016
2016

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 103 publications
(89 citation statements)
references
References 35 publications
(44 reference statements)
3
85
1
Order By: Relevance
“…Here we demonstrate for the first time that expression of miR-144 is upregulated in aged CMVECs and is reduced by CR. Interestingly, similar pattern of aging-and CR-induced changes in miR-144 expression has been observed recently in the skeletal muscle from rhesus monkeys (56). The findings that overexpression of miR-144 in young CMVECs and cells derived from aged CR rats significantly reduces Nrf2 expression, whereas expression of an antagomiR-144 upregulates Nrf2 in aged CMVECs, provide further evidence in support of the concept that dysregulation of miR-144 and Nrf2 in aging are causally linked.…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Here we demonstrate for the first time that expression of miR-144 is upregulated in aged CMVECs and is reduced by CR. Interestingly, similar pattern of aging-and CR-induced changes in miR-144 expression has been observed recently in the skeletal muscle from rhesus monkeys (56). The findings that overexpression of miR-144 in young CMVECs and cells derived from aged CR rats significantly reduces Nrf2 expression, whereas expression of an antagomiR-144 upregulates Nrf2 in aged CMVECs, provide further evidence in support of the concept that dysregulation of miR-144 and Nrf2 in aging are causally linked.…”
Section: Discussionsupporting
confidence: 83%
“…The pathways by which aging leads to persis- tent downregulation of Nrf2 in CMVECs likely involve posttranscriptional regulation of Nrf2 expression. There is growing evidence that miRNAs, which are important for the posttranscriptional regulation of numerous biological processes, are deregulated during aging (42,87), and some miRNAs have been implicated in age-associated decline of organ functions and development of age-related diseases (56). Analysis of age-related changes in miRNA expression profile in CMVECs (87) and existing data from the literature (56) identified miRNAs, such as miR-144, whose expression in upregulated in aging and whose predicted targets include Nrf2.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, dicer loss‐of‐function mutations in Caenorhabditis elegans reduce lifespan and homeostatic stress responses (Mori et al ., 2012). We reported that miRNA levels decrease with advancing age in human peripheral blood mononuclear cells (PBMCs) and primate skeletal muscle, while others have found decreased levels of miRNAs with age in mouse brain and in C. elegans (Noren Hooten et al ., 2010, 2013; Smith‐Vikos & Slack, 2012; Mercken et al ., 2013). Given the conservation of miRNAs across species, and that a single miRNA can regulate C. elegans lifespan and predict the mortality of individual C. elegans (Smith‐Vikos & Slack, 2012), it is likely that miRNAs play an important role in regulating lifespan in humans and other species.…”
Section: Introductionmentioning
confidence: 99%
“…This sequence was identified as an miRNA candidate by Berezikov et al (26), and was confirmed later by cloning (27). A previous study reported that it was overexpressed in radioresistant NPC cancer cells and it had significantly lower expression in skeletal muscle from aged persons (28). All of these implied its possible critical role in the DNA repair pathway.…”
Section: Discussionmentioning
confidence: 76%