2014
DOI: 10.1016/j.cell.2014.10.028
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Abstract: Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unexplored. We report that the Drosophila fat body, a major immune organ, undergoes immunosenescence and mounts strong systemic inflammation that leads to de-regulation of immune deficiency (IMD) signaling in the midgut of old animals. Inflamed old fat bodies secrete circulating peptidoglycan recognition pr… Show more

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Cited by 150 publications
(133 citation statements)
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References 79 publications
(74 reference statements)
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“…Our previous studies have shown that Drosophila aging is accompanied by a gradual reduction of lamin‐B, LAM (encoded by the gene Lam ) (Chen et al ., 2014). Since LAM is involved in maintaining heterochromatin, its loss could contribute to the age‐ associated increase in retrotransposon expression and DNA damage in fat bodies.…”
Section: Resultsmentioning
confidence: 99%
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“…Our previous studies have shown that Drosophila aging is accompanied by a gradual reduction of lamin‐B, LAM (encoded by the gene Lam ) (Chen et al ., 2014). Since LAM is involved in maintaining heterochromatin, its loss could contribute to the age‐ associated increase in retrotransposon expression and DNA damage in fat bodies.…”
Section: Resultsmentioning
confidence: 99%
“…Previously, we have shown that age‐associated LAM reduction in fat bodies leads to increased systemic inflammation, which contributes to gut hyperplasia in old flies (Chen et al ., 2014). Repression of activities of the immune deficiency (IMD) pathway in old fat bodies can only partially reverse the hyperplastic phenotype in the gut.…”
Section: Discussionmentioning
confidence: 99%
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