2014
DOI: 10.18632/aging.100705
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Abstract: Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dys-regulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation gene expression mediated by the transcription factor NF-κB is higher in purified and rested human CD4+ T lymphocytes from older compared to younger individuals. This increase of NF-κB-associated transcription includes transcripts for p… Show more

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Cited by 42 publications
(48 citation statements)
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References 47 publications
(52 reference statements)
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“…For example, gene-expression studies show that CD4 + lymphocytes from older individuals have higher intrinsic activation of the NF-κB pathways than those from younger individuals 120 . After stimulation with anti-CD3, the production of pro-inflammatory cytokines in vitro is lower in cells from older individuals than in cells from younger individuals 120 , a phenomenon that might be related to altered metabolic activity 121 . However, because these studies have been performed only in small populations, their relevance to inflammageing is unknown.…”
Section: Risk Factors and Causes Of Inflammageingmentioning
confidence: 99%
“…Increased PI3K signaling has been reported in the peripheral blood mononuclear cells [260] and CD4+ lymphocytes [261] from old human donors. Animal studies also showed that PI3K signaling was increased in skeletal muscle (26 mo vs. 6 mo) [262] and heart of old rats [263], and macrophages of old mice [264].…”
Section: Introductionmentioning
confidence: 99%
“…38 For example, a regulator of lung morphogenesis that is lower in childhood, nuclear factor kappa-light-chainenhancer of activated B cells (NF-b), plays a pathologic role in inflammatory diseases and should be evaluated as a protective host factor in pediatric versus adult SARS-CoV-2 infections. 38,39 Indeed, even outside the context of SARS-CoV-2 infections, rates of ARDS are A c c e p t e d M a n u s c r i p t 9 lowest in children and increase with age, suggesting a role for protective host factors in the lungs of children. 40,41 Innate and adaptive Immunity: Th1 responses are thought to be important for immune protection against SARS-CoV-1 since increased Th2 cytokines were identified in patients with fatal disease.…”
Section: Disease Mitigating Characteristics Of Childrenmentioning
confidence: 99%
“…The imbalance between adaptive and innate immunity seems to be causally involved in the proinflammatory phenotype observed in elderly, which is also related to autoimmunity. In this regard, NF-κB, as the main regulator of innate immunity, is critically involved in thymic involution and in other immune-related alterations (Osorio et al, 2012a;Kawahara et al, 2009;Bektas et al, 2014).…”
Section: Immunosenescencementioning
confidence: 99%
“…In this regard, it has been demonstrated that T cells show age-related NF-κB hyperactivation and subsequently, they secrete higher levels of proinflammatory cytokines (Bektas et al, 2014). The reversal of immune alterations upon NF-κB inhibition in vitro and in vivo demonstrates that this inhibitory strategy could be useful for improving immune activity during ageing (Osorio et al, 2012a;Tilstra et al, 2012;Kawahara et al, 2009;Huang et al, 2008).…”
Section: Immunosenescencementioning
confidence: 99%