volume 10, issue 4, P789-807 2018
DOI: 10.18632/aging.101428
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Byungkuk Min, Myungsun Park, Kyuheum Jeon, Jung Sun Park, Hyemyung Seo, Sangkyun Jeong, Yong-Kook Kang

Abstract: This study addressed the question of how well the quantitative transcriptome structure established in early life is maintained and how consistently it appears with increasing age, and if there is age-associated alteration of gene expression (A3GE), how much influence the Huntington’s disease (HD) genotype exerts on it. We examined 285 exonic sequences of 175 genes using targeted PCR sequencing in skeletal muscle, brain, and splenic CD4+ T cells of wild-type and HD mice. In contrast to the muscle and brain, T c…

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