Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Changchien, Lily; Dusza, Stephen W.; Agero, Anna Liza C.; Korzenko, Adam; Braun, Ralph P.; Sachs, Dana L.; Usman, Muhammad; Halpern, Allan C.; Marghoob, Ashfaq A.

doi:10.1001/archderm.143.8.1007

Cited by 89 publications

(74 citation statements)

References 31 publications

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“…The predominant patterns of all melanocytic nevi were globular (50 %), consistent with prior studies [7]. They also observed a reticular pattern among nevi present at birth (28 %), which contradicts previous descriptions of a predominately reticular pattern in CMN for individuals 12 years or older [7,8]. The presence of both globular and reticular patterns in CMN raises questions regarding nevus evolution and pathways responsible for nevogenesis.…”

Section: Congenital Melanocytic Nevisupporting

confidence: 76%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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Pigmented lesions and melanocytic nevi are commonly evaluated lesions in pediatric dermatology clinics and the rising incidence of melanoma has increased public awareness of malignant potential. Diagnosis and management of pigmented lesions, especially dysplastic nevi, medium and large congenital melanocytic nevi (CMN), and Spitz nevi, can be particularly challenging. We summarize the recent literature for melanocytic nevi and pigmented lesions as relevant to the practice of pediatric dermatology with particular attention to dermatoscopic techniques, histopathologic interpretation, molecular biology, and management recommendations for CMN and Spitz nevi.

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Section: Congenital Melanocytic Nevisupporting

confidence: 76%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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“…Of note is the fact that the number of these vessels in the lesion may not be very many and thus may be referred to as lonely arborising vessels that may traverse the length of the lesion. The finding of yellowish white structureless areas to globules on dermoscopy is similar to the milia like cysts that have been described as variously sized white or yellowish structures in seborrhoeic keratoses and congenital melanocytic nevi [2][3][4].…”

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confidence: 75%

Vascular pattern of milia on dermatoscopy

Malakar¹,

Mukherjee²

2017

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“…In a recently published work, Changchien et al[ 14] observed additional dermoscopic features in CMN which they added to those proposed by Seidenari and Pellacani [1] and Seidenari et al [2, 3]: the milia-like cysts (characteristic dermoscopic finding of seborrheic keratosis) and the haloed globules , which are globules surrounded by a hypopigmented halo. The authors structurally differentiated haloed globule from target globule, which was initially described by Seidenari et al as a clear globule containing a central dot.…”

Section: Discussionmentioning

confidence: 87%

Reproducibility of Dermoscopic Features of Congenital Melanocytic Nevi

et al. 2008

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Background: The dermoscopic features of congenital melanocytic nevi (CMN) have recently been described, and some structures have been proposed as distinctive of these moles. Objective: The aim of our study was to evaluate the agreement between observers, i.e. the reproducibility, in the identification of these features. Method: Fifty-two CMN, randomly selected from 127 male subjects carrying at least 1 CMN, were examined by a 1st medium-experienced observer. The image recording was performed according to the dermoscopic patterns of the Consensus Net Meeting on Dermoscopy and to the features proposed for CMN by Seidenari et al. The presence/absence of these features was recorded in a specifically developed patient’s card, and the most typical dermoscopic features of the lesions were also photographed and observed again in this form by the same investigator and by a 2nd basic-experienced observer. The reproducibility of the dermoscopic features assessed directly and on photographs by the 1st observer (intraobserver agreement) and the agreement between the 1st and the 2nd observers judging nevi on photographs (interobserver agreement) were estimated by Cohen’s kappa statistics. Results: Intraobserver agreement was highly satisfactory for all the dermoscopic features, with the exception of focal thickening of network lines and follicles (satisfactory), and hyperpigmented areas and target vessels (fairly satisfactory), which were more frequently identified on Dermaphot pictures. Interobserver agreementwas highly satisfactory for network, globules/dots, blotches, focal hypopigmentation, skin furrow hypopigmentation and follicles; it was satisfactoryfor perifollicular hypopigmentation, vessels and target vessels, and barely satisfactory for focal thickening of network lines, target globules and hyperpigmented areas; finally, it was fairly satisfactory for target network. Conclusion: The identification of dermoscopic features of CMN seems to show a good reproducibility, with a satisfactory intra- and interobserver agreement. Other studies involving a higher number of experienced and less experienced observers are requested to confirm these results.

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Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Abstract: To describe the dermoscopic features of congenital melanocytic nevi (CMN) and assess whether predominant dermoscopic patterns present in CMN are related to an individual's age ( Ͻ12 years vs Ն12 years), sex, or lesional site (head, neck, and trunk vs extremities).

Cited by 89 publications

References 31 publications

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

Vascular pattern of milia on dermatoscopy

Reproducibility of Dermoscopic Features of Congenital Melanocytic Nevi

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