Age- and sex-related changes in iliac cortical bone mass and remodeling

Brockstedt, H.; Kassem, Moustapha; Eriksen, Erik Fink; Mosekilde, Lis; Melsen, F.

doi:10.1016/8756-3282(93)90092-o

Cited by 191 publications

(131 citation statements)

References 35 publications

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“…In our study age influenced loss of BMD in the calcar region perhaps because thicker stems were used due to a wider femoral canal or because these patients are more sensitive to stress shielding. Differences in remodelling activity between younger and older patients have been reported, both at the cellular level [6] and at the macroscopic level [4]. Our findings suggest that younger patients may have a different remodelling pattern after insertion of orthopaedic implants.…”

Section: Discussionmentioning

confidence: 43%

Five-year DEXA study of 88 hips with cemented femoral stem

Digas

Kärrholm

2008

International Orthopaedics (SICOT)

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We performed repeated dual-energy X-ray absorptiometry (DEXA) measurements over five years in a homogeneous patient population to study the effect of a cemented stem on proximal femoral bone remodelling. Data from 88 patients (88 hips) implanted with total hip arthroplasty (THA) prostheses were extracted from three randomised studies. Femoral bone mineral density (BMD) was measured using a Lunar DPX-IQ densitometer for five years postoperatively. At one year the BMD changes had decreased between −2.0% [region of interest (ROI) 1] and −11.5% (ROI 7). During the follow-up period the BMD initially increased during the second year and thereafter decreased again in ROIs 5, 6 and 7. The loss of BMD at five years was more pronounced in region 7 (12.9%) and decreased with increasing age, total hip replacement (THR) on the right side and decreasing weight of the patient. We found that after the initial phase of early bone loss a period of recovery follows. Thereafter the BMD decreases again, which probably reflects the normal ageing of bone after uncomplicated cemented THA.Résumé Nous avons réalisé des examens avec des mesures répétées de densité osseuse (DEXA) sur une période de 5 ans dans une population homogène de patients ayant bénéficié de la mise en place d'une prothèse fémorale cimentée avec évaluation de remodelage osseux. Nous avons extrait les données de 88 patients (88 hanches) de trois études randomisées. La densité minérale osseuse fémorale a été mesurée par densitomètre Lunar DPX-IQ durant les cinq années post-opératoires. A un an, la densité minérale osseuse diminue de −2% (zone 1) et de −11,5% (zone 7). Durant la période d'observation la densité minérale osseuse augmente au cours de la deuxième année et puis diminue à nouveau en zones 5, 6 et 7. La perte de densité osseuse à cinq ans est moins importante en zone 7 (12,9%) et diminue lorsque l'âge augmente notamment du côté droit et en fonction du poids des patients. Nous avons ainsi montré, qu'après une phase initiale de déminéralisa-tion osseuse il existe une phase de reminéralisation puis la densité minérale osseuse diminue à nouveau ceci étant probablement dans les prothèses totales de hanches non compliquées le reflet de l'âge.

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Section: Discussionmentioning

confidence: 43%

Five-year DEXA study of 88 hips with cemented femoral stem

Digas

Kärrholm

2008

International Orthopaedics (SICOT)

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“…A positive relationship between haversian canal size and age has been reported for the ilium by Broulik et al (1982) and Brockstedt et al (1993) and for the femur by Thompson (1980) andJowsey (1966). Our measurement of pores included all intracortical pores but most of these would have been quiescent haversian canals.…”

Section: mentioning

confidence: 95%

Determination of age at death using combined morphology and histology of the femur

Thomas

Stein²,

Feik

et al. 2000

Journal of Anatomy

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Bone is characterised by age-related morphological and histological changes. We have previously established an automated method of recording bone morphometry and histology from entire transverse sections of cortical bone. Our aim was to determine whether data acquired using this automated system were useful in the prediction of age. Ninety-six specimens of human femoral middiaphysis were studied from subjects aged 21-92 y. Equations predicting specimen age were constructed using macroscopic data (total subperiosteal area (TSPA), periosteal perimeter (PP), endosteal perimeter (EP), cortical bone area (CA) and moments of area) and microscopic data (the number, size and diversity of pores and intracortical porosity) together with sex, height and weight. Both TSPA and PP were independent predictors of age but the number of pores was not a significant predictor of age in any equation. The age predicted by these equations was inaccurate by more than 8 y in over half the subjects. We conclude that we could not predict age at a clinically acceptable level using data from our automated system. This most likely reflects an insensitivity to regional age-related changes in bone histology because we recorded data from each entire cortex. Automated bone measurement according to cortical region might be more useful in the prediction of age. The inclusion of TSPA together with PP as independent predictors of age raises the possibility that a future measure of periosteal shape at the femoral diaphysis could also be helpful in the prediction of age. The accuracy reached with the relatively simple methods described here is sufficient to encourage the development of image-analysis systems for the automatic detection of more complex features.

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“…Concerning the sexual dimorphism, TC and AC were thicker or wider in male than in female in raccoon dogs, and BS, DS and AM were larger in male than in female in badgers. Brockstedt [3] described that the osteon diameter was significantly larger in men than in women. The present results also revealed that DO showed larger values in males of both species, with a significant difference between sexes in raccoon dogs.…”

Section: Discussionmentioning

confidence: 99%

“…This is particularly true for bones of the limbs of raccoon dogs and badgers. Because the mid-shaft is less characteristic in form as compared with the proximal and distal extremities of the limb bones, macroscopic identification of raccoon dogs and badgers is extremely difficult.A large number of histometrical studies were made on the bones of human [2,3,6,17,18], which described mainly age changes. Human bones, excavated from archaeological sites, were also examined histometrically [4,8,14].…”

mentioning

confidence: 99%

A Histometrical Study on the Long Bones of Raccoon Dogs, Nyctereutes procyonoides and Badgers, Meles meles.

et al. 1998

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ABSTRACT. To obtain the data required for identification of skeletal remains excavated from archaeological sites, histometrical observations were made in the cross sections of the mid-shaft of humerus, radius, femur and tibia of raccoon dogs (Nyctereutes procyonoides) and badgers (Meles meles) captured in Kagoshima Prefecture. There were interspecific differences between both animals in the breadth, the depth and the area of medullary cavity at the mid-shaft of the bones. In badgers, all measurements were greater in male than in female bones. The thickness and the area of compact bones in male raccoon dogs were larger than those of female. No differences in histological structure could be detected among the bones, but an interspecific difference was found in the shape of osteons; round and constant-sized osteons consisting of 3 to 5 lamellae in raccoon dogs, while round or elliptic osteons varying in size from 3 to 8 lamellae in badgers. The ratios, the osteon areas per unit compact bone areas, were higher in all the bones of raccoon dogs. The short diameters of osteons and the ratios were greater in males in both animals. In females, the short diameter of osteons was smaller, and the number of osteons was larger. The results revealed interspecific differences between both animals and sexual dimorphism in each species. -KEY WORDS: badger, bone histometry, interspecific difference, raccoon dog, sexual dimorphism.J. Vet. Med. Sci. 60(3): 323-326, 1998 in the present study. The animal with the closed epiphyseal lines of long bones was regarded as adult. Two cross sections (1 mm thick) were obtained from each mid-shaft of the bone. The specimens were dehydrated in a graded ethanol series and embedded in Rigorac, a polyester resin to prepare undecalcified ground sections (30 to 40 µm thick). After the ground sections were observed with a light microscope, 9 items shown in Table 1 with their abbreviations were measured with an image analyzer (Nikon COSMOZONE Is) in each section. NO, DO and RO were measured at the anterior, posterior, medial and lateral regions (1 mm 2 each) of the section of each bone. These data were compared between species, sexes or kinds of bones using Student's t-test. RESULTS Morphometrical observations in cross sections:The values obtained in cross sections of the mid-shaft of each Recently, a number of skeletal remains of animals including those belonging to the canid and mustelid species were excavated from archaeological sites in Kyushu [13]. Only a few complete skeletons were found, however, and most discoveries were bone fragments. In such cases, it is difficult to identify species with bones similar in size. This is particularly true for bones of the limbs of raccoon dogs and badgers. Because the mid-shaft is less characteristic in form as compared with the proximal and distal extremities of the limb bones, macroscopic identification of raccoon dogs and badgers is extremely difficult.A large number of histometrical studies were made on the bones of human [2,3,6,17,18], which described...

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Age- and sex-related changes in iliac cortical bone mass and remodeling

Cited by 191 publications

References 35 publications

Five-year DEXA study of 88 hips with cemented femoral stem

Five-year DEXA study of 88 hips with cemented femoral stem

Determination of age at death using combined morphology and histology of the femur

A Histometrical Study on the Long Bones of Raccoon Dogs, Nyctereutes procyonoides and Badgers, Meles meles.

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