Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells

Olivieri, Fabiola; Bonafè, Massimiliano; Spazzafumo, Liana; Gobbi, Mirko; Prattichizzo, Francesco; Recchioni, Rina; Marcheselli, Fiorella; Sala, Lucia La; Galeazzi, Roberta; Rippo, Maria Rita; Fulgenzi, Gianluca; Angelini, Sabrina; Lazzarini, Raffaella; Bonfigli, Anna Rita; Brugè, Francesca; Tiano, Luca; Genovese, Stefano; Ceriello, Antonio; Boemi, Massimo; Franceschi, Claudio; Procopio, Antonio; Testa, Roberto

doi:10.18632/aging.100693

Cited by 96 publications

(88 citation statements)

References 62 publications

(87 reference statements)

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“…Our data demonstrated that the expression of circulating miR-126-5p could also be influenced by some traditional cardiovascular risk factors, including aging, DM and hyperlipidemia, which is in accordance with previous studies [23,[32][33][34]. It is worth noting that although these risk factors have been reported to be critically involved in the formation of atherosclerosis, circulating miR-126-5p is a potential independent predictive factor for the severity of cardiovascular artery disease.…”

Section: Discussionsupporting

confidence: 91%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao²,

Liu³

et al. 2016

Cell Physiol Biochem

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Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. However, the relationship between miR-126 and the severity of CAD remains unknown. This study was designed to test whether circulating miR-126 levels are associated with the severity of CAD. Methods: The present study enrolled 40 patients who had risk factors for CAD without angiographically significant CAD, and 110 patients presenting with stable angina pectoris, who were validated left main coronary artery disease (LMCA) and/or multi-vessel disease by coronary angiography. The expression levels of plasma miR-126-5p from all enrolled subjects were estimated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationships between plasma miR-126-5p levels, number of diseased vessels and the corresponding Synergy between PCI with Taxus and Cardiac surgery (SYNTAX) score were analyzed. Results: The expression of circulating miR-126-5p was affected by some CAD risk factors including aging, dyslipidemia and DM. Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score. Conclusion: Circulating miR-126-5p has emerged as a potential biomarker for complexity and severity of CAD in patients with stable angina pectoris.

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Section: Discussionsupporting

confidence: 91%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao²,

Liu³

et al. 2016

Cell Physiol Biochem

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“…In addition, given that miRNAs mostly function as intra-cellular modulators of mRNAs, their concentration in whole blood might be a poor indicator of their physiological effects. Nonetheless, miR-25–3p, miR-92a-3p, miR-93–5p, miR-101–3p, miR-106b-5p, miR-142–5p, miR-151a-3p, and miR-181a-5p tend to be under-represented, whereas miR-21–5p and miR-126–3p are over-represented at older ages 47,49,50 . Age-related changes in miRNAs have been suggested to contribute to inflammageing.…”

Section: Risk Factors and Causes Of Inflammageingmentioning

confidence: 93%

“…Age-related changes in miRNAs have been suggested to contribute to inflammageing. For example, miR-126–3p inhibits endothelial inflammation, and low levels of miR-126–3p were found in patients with CVD and diabetes 50 , whereas miR-21–5p levels are correlated negatively with CRP and fibrinogen levels, and miR-21–5p levels are higher in patients with CVD than in age-matched controls 44 . Other miRNAs, such as miR-146 and miR-155, might also have a role in inflammageing by affecting cellular senescence or modulating immune responses, although these activities might not be reflected by changes in miRNA concentration or these miRNAs might be detected only in exosomes or other structures carrying miRNAs 51 .…”

Section: Risk Factors and Causes Of Inflammageingmentioning

confidence: 99%

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

2018

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Most older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death. Potential mechanisms of inflammageing include genetic susceptibility, central obesity, increased gut permeability, changes to microbiota composition, cellular senescence, NLRP3 inflammasome activation, oxidative stress caused by dysfunctional mitochondria, immune cell dysregulation, and chronic infections. Inflammageing is a risk factor for cardiovascular diseases (CVDs), and clinical trials suggest that this association is causal. Inflammageing is also a risk factor for chronic kidney disease, diabetes mellitus, cancer, depression, dementia, and sarcopenia, but whether modulating inflammation beneficially affects the clinical course of non-CVD health problems is controversial. This uncertainty is an important issue to address because older patients with CVD are often affected by multimorbidity and frailty — which affect clinical manifestations, prognosis, and response to treatment — and are associated with inflammation by mechanisms similar to those in CVD. The hypothesis that inflammation affects CVD, multimorbidity, and frailty by inhibiting growth factors, increasing catabolism, and interfering with homeostatic signalling is supported by mechanistic studies but requires confirmation in humans. Whether early modulation of inflammageing prevents or delays the onset of cardiovascular frailty should be tested in clinical trials.

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“…miRNAs emerged as important biomarkers and therapeutic target for several conditions, including HF (163). Numerous miRNAs, such as miR-146, miR-155, miR-21, miR-126 appear to be involved in the aging process (164,165), in cardiac remodeling observed with aging (166,167) and are associated with prognosis and response to therapy in HF (163).…”

Section: Micrornas (Mirnas) and Long Non Coding Rnas (Lncrna)mentioning

confidence: 99%

Role of circulating factors in cardiac aging

et al. 2017

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Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations in regulators of tissue physiology may regulate this process. Cardiac aging itself is a major risk factor for cardiovascular diseases and, because of the intimate relationship with the brain, may contribute to increase the risk of neurodegenerative disorders. Blood-borne factors may play a major role in this complex and still elusive process. A number of studies, mainly based on the revival of parabiosis, a surgical technique very popular during the 70s of the 20 th century to study the effect of a shared circulation in two animals, have indeed shown the potential that humoral factors can control the aging process in different tissues. In this article we review the role of circulating factors in cardiovascular aging. A better understanding of these mechanisms may provide new insights in the aging process and provide novel therapeutic opportunities for chronic age-related disorders.

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Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells

Cited by 96 publications

References 62 publications

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Role of circulating factors in cardiac aging

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