Age- and gender-dependent association of the –344C/T polymorphism of CYP11B2 with blood pressure in European populations

Russo, Paola; Loguercio, M.; Lauria, Fabio; Barba, Gianvincenzo; Arnout, Jozef; Cappuccio, Francesco P.; Iacoviello, Licia; Siani, Alfonso

doi:10.1038/sj.jhh.1002136

Cited by 18 publications

(11 citation statements)

References 12 publications

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“…Moreover, we noted a significant gene-by-gender interaction with BP traits in this study. Several studies have reported gender-specific effects of gene variants and gene-bygender interactions in human hypertension [21][22][23][24] ; these data support our findings. As for the mechanism by which six common SNPs (rs2236055, rs4240897, rs1474868, rs2336384, rs873457 and rs4846085) might contribute to essential hypertension only in males, more studies are needed, although it was in accordance with the fact that males had higher incidences of essential hypertension than females 25) .…”

Section: Discussionsupporting

confidence: 83%

HSG/Mfn2 Gene Polymorphism and Essential Hypertension: a Case-Control Association Study in Chinese

Wang

Liu

et al. 2011

JAT

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Aim: Hyperplasia suppressor gene/mitofusion-2 (HSG/Mfn2) is a hyperplasia suppressor gene and an essential component of mitochondrial fusion machinery; however, the association between the single nucleotide polymorphism (SNP) of HSG/Mfn2 and hypertension is unclear. Methods: In this study, 542 normotensive subjects (NT group) and 539 hypertensive patients (EH group) were screened for an association study between HSG/Mfn2 and hypertension. Results:The results showed that the genotype distribution and allelic frequency of rs873457, rs2336384, rs1474868, rs4846085 and rs2236055 were significantly different (P 0.05 for all) between EH and NT groups, although those of rs4240897 and rs873458 were not. When comparing the dominant model, significant differences still existed (P 0.05 for all). The allelic frequency of rs4240897 was also slightly different between EH and NT groups (P 0.047). When subgrouped by sex, the genotype distribution and allelic frequency of all the SNPs (except rs873458) were significantly different in male (P 0.05 for all) but not in female groups. For all the SNPs, only the allelic frequency of rs4240897 was obviously different in female NT and EH groups (P 0.01). Logistic regression showed that body mass index and rs873457 were closely associated with BP after adjusting for age. The frequency of the C-G-A-A-A-C-C haplotype was significantly higher in essential hypertensive patients versus control individuals, both in the entire population, in male or female groups (P 0.01 for all). As for other haplotypes, most were only significantly different in the entire population and male subjects. Conclusion: The genetic variations of HSG/Mfn2 may be associated with hypertension in male Chinese.J Atheroscler Thromb, 2011; 18:24-31.

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Section: Discussionsupporting

confidence: 83%

HSG/Mfn2 Gene Polymorphism and Essential Hypertension: a Case-Control Association Study in Chinese

Wang

Liu

et al. 2011

JAT

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“…2 K So far, dozens of studies associating C-344T with hypertension have been conducted, whereas results are often irreproducible. [3][4][5][6] What this study adds K No deviation from the Hardy-Weinberg equilibrium was observed for the C-344T polymorphism in our study population. K There were no statistical differences in the genotype/allele distributions of the C-344T polymorphism between cases and controls (P40.05).…”

Section: Conflict Of Interestmentioning

confidence: 53%

“…2 So far, dozens of studies associating C-344T with hypertension have been conducted, whereas results are often irreproducible. [3][4][5][6] It is generally accepted that an association study, coupled with functional validation, represents a powerful approach to deciphering the genetic makeup of complex disease. 7 However, a literature search did not trace any functional hints about the promoter activity changes driven by C-344T.…”

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confidence: 99%

“…[3][4][5][6] On the basis of a recent meta-summarization on 42 association studies, Sookoian et al 9 suggested that À344CC homozygotes had a lower risk of hypertension than did their À344TT counterparts, whereas no significance held for the overall risk estimates from the randomeffects model considering the clear between-studies heterogeneity. Further pooled phenotype-genotype association on plasma aldosterone levels as well as systolic and diastolic arterial BP still yielded no positive evidence.…”

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confidence: 99%

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Genetic and functional analyses of aldosterone synthase gene C-344T polymorphism with essential hypertension

Zhang

et al. 2010

J Hum Hypertens

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“…There is evidence that male sex hormones contribute to the exacerbation of hypertension in spontaneously hypertensive rats by reducing pressure-natriuresis. 29 Russo et al 30 found À344C/T to be associated with higher BP and prevalence of hypertension in younger men but not in women. Several other studies have also reported gender-specific effects of gene variants and gene-by-gender interactions in human hypertension.…”

Section: Discussionmentioning

confidence: 97%

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

Wang

Zhang

et al. 2014

Hypertens Res

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Hypertension is one of the leading risk factors for mortality. The renin-angiotensin-aldosterone system (RAAS) is a potent and powerful mediator in the homeostasis of hypertension. Here, the association between six candidate genes, renin, adrenoceptor β3, angiotensinogen, aldosterone synthase, angiotensin II receptor type 1 and angiotensin II receptor type 2, that are related to RAAS and essential hypertension (EH) was evaluated and explored in northern Chinese Han individuals. A case-control study including 1090 EH cases and 700 controls was performed. Eight single-nucleotide polymorphisms (SNPs), rs699, rs4762, rs5707, rs5186, rs4994, rs1799998, rs5193 and rs5194, located in the six genes were genotyped with TaqMan real-time PCR method. Statistical analysis software (SPSS 17.0) was used for descriptive statistics and association analyses. Among the six genes related to RAAS, the frequencies of rs4994 (ADRB3) and rs5194 (AGTR2) were found to be significantly different between the EH cases and controls (P < 0.05). Logistic regression analyses adjusted for covariates showed rs4994 to be closely associated with EH under the recessive (P = 0.019, odds ratio (OR) = 0.373, 95% confidence interval (CI) 0.163-0.851) and homozygous (P = 0.028, OR = 0.394, 95% CI 0.172-0.903) models. The association was also significantly close in the male subset (P < 0.05). Significant association was also observed between rs1799998 (CYP11B2) and EH (P < 0.05) in the dominant, additive and allelic models. These data demonstrated that ADRB3 rs4994 and CYP11B2 rs1799998 were significantly closely associated with EH in northern Han Chinese individuals. The CC of rs4994 and CC or C allele of rs1799998 might be protective genetic factors of hypertension.

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Age- and gender-dependent association of the –344C/T polymorphism of CYP11B2 with blood pressure in European populations

Cited by 18 publications

References 12 publications

HSG/Mfn2 Gene Polymorphism and Essential Hypertension: a Case-Control Association Study in Chinese

HSG/Mfn2 Gene Polymorphism and Essential Hypertension: a Case-Control Association Study in Chinese

Genetic and functional analyses of aldosterone synthase gene C-344T polymorphism with essential hypertension

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

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