After infection with Leishmania infantum, Golden Hamsters (Mesocricetus auratus) become more attractive to female sand flies (Lutzomyia longipalpis)

Nevatte, Tracy; Ward, R. D.; Sedda, Luigi; Hamilton, James G. C.

doi:10.1038/s41598-017-06313-w

Cited by 20 publications

(31 citation statements)

References 32 publications

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“…have shown increased attractiveness to malaria vectors and differences in the volatile compounds released by these hosts [15–18]. The same pattern has been suggested for the aetiological agent of visceral leishmaniasis, since increased attractiveness of Leishmania infantum- infected hosts to the parasite’s vector Lutzomyia longipalpis has been demonstrated [19,20]. In a cross-sectional study, when different uninfected and infected animals were evaluated in the same moment, it was suggested that differences in the attractiveness of L .…”

Section: Introductionmentioning

confidence: 78%

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Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae)

et al. 2019

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Background Phlebotomine sand flies are vectors for several pathogens, with Leishmania being the most important. In Brazil, the main aetiological agent of American cutaneous leishmaniasis (ACL) is Leishmania (Viannia) braziliensis , and Nyssomyia neivai is one of its main vectors in São Paulo state and other areas of South America. Similar to other haematophagous insects, sand flies use volatile compounds called kairomones to locate their hosts for blood meals. A possible increase in the attractiveness of hosts infected with Leishmania infantum to their vectors has been demonstrated. In the present study, we aimed to investigate whether L . braziliensis -infected hosts present higher attractiveness to Ny . neivai and to identify differences in the volatile compounds released by infected and uninfected mice. Results Behavioural experiments in which sand fly females directly fed on infected or uninfected mice showed no significant differences in the attractiveness of the mice or the blood volume ingested. Y-tube olfactometer bioassays also revealed no significant differences in the attractiveness of these hosts to Ny . neivai . No differences were observed in the profiles of the volatile compounds released by the two groups of mice. However, PCA and cluster analysis were able to classify the 31 identified compounds into three clusters according to their abundances. This classification showed a possible role for individual variation in the absence of differences in volatile profiles and attractiveness between infected and uninfected mice. Conclusion In this first cross-sectional study with an aetiological agent of ACL, there were no statistically significant differences in the attractiveness of infected hosts to their vector.

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Section: Introductionmentioning

confidence: 78%

“…infantum exhibited increased attractiveness to L . longipalpis [20]. Until now, among more than 30 species of Leishmania , no study on this topic has addressed species that cause cutaneous leishmaniasis.…”

Section: Introductionmentioning

confidence: 99%

Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae)

et al. 2019

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“…Moreover, studies in Lu. longipalpis showed a preference for volatile compounds from hamsters infected with L. infantum in comparison with non‐infected hamsters (Nevatte et al ., ). This possible host modification by the parasite has been also demonstrated for Plasmodium sp.…”

Section: Percentages Of Lutzomyia Longipalpis Males and Females Activmentioning

confidence: 97%

“…longipalpis after infection. These results suggest a parasite‐induced modification of the host metabolism for the production of VOCs as a way of attracting vectors and increasing their dissemination (Nevatte et al ., ). The present study was not designed to discuss the possible modification of infected dogs by L. infantum to induce the emission of VOCs in these hosts.…”

Section: Percentages Of Lutzomyia Longipalpis Males and Females Activmentioning

confidence: 97%

Attraction of the sandfly Lutzomyia longipalpis to possible biomarker compounds from dogs infected with Leishmania infantum

Magalhães-Junior

Oliva‐Filho

Novais

et al. 2019

Medical Vet Entomology

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Lutzomyia longipalpis (Diptera: Psychodidae) is the primary vector of Leishmania infantum (Kinetoplastida: Trypanosomatidae) in the Americas. Studies have been carried out to identify new alternatives for monitoring and controlling this sandfly species, particularly with the use of chemical baits. The attractiveness of odours emitted by foxes and alcohols found in some plants has already been demonstrated in laboratory tests with Lu. longipalpis. However, no studies have evaluated the responses of these insects to volatile organic compounds (VOCs) emitted by dogs. The present study was carried out to investigate the effects on Lu. longipalpis of individual and blends of VOCs identified in hair from dogs infected with L. infantum. Effects in male and female Lu. longipalpis were assessed using wind tunnel methodology. Individual compounds including octanal, nonanal, decanal and heptadecane showed capacity for activating and/or attracting male Lu. longipalpis. Only decanal and nonanal showed effects on females. The combination of octanal, decanal and heptadecane increased activation and attraction behaviour in male sandflies, as did the blend of octanal and decanal. These findings indicate that VOCs emitted by dogs may be an interesting source of new attractants of sandflies.

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“…The odours of golden hamsters infected with Le. infantum are more attractive to female sand flies than the odours of uninfected hamsters (O'Shea et al, 2002;Nevatte et al, 2017). The odour obtained from the hair of dogs infected with Le.…”

Section: Introductionmentioning

confidence: 99%

Volatile organic chemical analyser (eNose) diagnosis of dogs naturally infected with visceral leishmaniasis in Brazil

Staniek

Sedda

Gibson

et al. 2019

Preprint

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Visceral leishmaniasis (VL) in Brazil is a neglected vector-borne tropical parasitic disease that is responsible for several thousand human deaths every year. The numbers of cases more than doubled between 1990 and 2016. Transmission occurs when sand flies become infected after feeding on infected dogs (the reservoir host) and then subsequently on humans. A major component of the VL control effort is the identification and euthanasia of infected dogs to remove them as a source of infection. Rapid, accurate identification of infected dogs would be key to this strategy.Here we demonstrate the potential of a volatile organic chemical analyser (eNose) to rapidly and accurately identify dogs infected with Leishmania infantum parasites. The eNose could discriminate between the odours present in the hair of infected and uninfected dogs with greater than 95% sensitivity and 95% specificity.The device was sufficiently sensitive to be able to identify infected dogs even when parasite loads in the circulating blood were very low.Future improvements to VOC analyser technology, portability and ease of use suggest that this methodology could significantly improve the diagnosis of VL infected dogs in Brazil and elsewhere and with other parasitic diseases such as Malaria, Chaga's Disease and Leishmania in humans.

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After infection with Leishmania infantum, Golden Hamsters (Mesocricetus auratus) become more attractive to female sand flies (Lutzomyia longipalpis)

Cited by 20 publications

References 32 publications

Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae)

Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae)

Attraction of the sandfly Lutzomyia longipalpis to possible biomarker compounds from dogs infected with Leishmania infantum

Volatile organic chemical analyser (eNose) diagnosis of dogs naturally infected with visceral leishmaniasis in Brazil

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