After-effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer’s disease

Han, Wen; Zhou, Lu-Xu; Luo, Yinpei; Hou, Wensheng; Wang, Xing; Tian, Xiaobin

doi:10.1016/j.nlm.2019.02.002

Cited by 20 publications

(24 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the level of GFAP expression in the AD group was significantly higher than that in the CTL group (Figures 5C, 7B). In the ADT group treated with AtDCS, GFAP expression levels were decreased, and Aβ 42 was surrounded by activated astrocytes (Figure 7C), which is consistent with previous studies (Itagaki et al, 1989;Yu et al, 2015;Zhu et al, 2017;Yang et al, 2019). However, AtDCS increases glial activation in the early stages and decreases with time (Rueger et al, 2012;Pikhovych et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

“…Compared with the CTL group, the AD group and the ADT group had different expression levels of GFAP, indicating that the AD group and the ADT mice had different degrees of inflammatory abnormalities, consistent with our previous studies (Yu et al, 2015;Yang et al, 2019). Neuroinflammation is an early pathological manifestation in the AD brain and is a basic protective immune response in the central nervous system (Eikelenboom et al, 2010).…”

Section: Discussionsupporting

confidence: 88%

“…There is currently no direct mechanism study on the application of tDCS to AD. In our previous studies, anodal tDCS (AtDCS) improved spatial learning and memory in an AD rat model, and the activity of astrocytes was significantly reduced (Yu et al, 2015), an effect that lasted for 2 months (Yang et al, 2019). AtDCS reduces the number of dysfunctional astrocytes and, in turn, reduces neurotoxicity, which may be the reason why AtDCS improves spatial learning and memory in AD rats.…”

Section: Introductionmentioning

confidence: 93%

“…At this time, all four groups of mice were 6 months of age. Based on our previous protocol (Yu et al, 2015;Yang et al, 2019), electrodes were installed in APP/PS1 mice 1 day prior to stimulation. The anode electrode was a cylindrical plastic tube made of polyvinyl chloride, and was filled with a sponge and an outer guiding copper wire (diameter: 2 mm), the effective contact area of which was 3.14 mm 2 .…”

Section: Anodal Transcranial Direct Current Stimulationmentioning

confidence: 99%

See 3 more Smart Citations

Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice

Luo

Yang

et al. 2020

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease. Intervention in the early stage of AD is a new path for AD treatment that is being explored. The behavioral and pathological effects of anodal transcranial direct current stimulation (AtDCS) at the early stage of AD in the mouse model, amyloid precursor protein (APP)/presenilin-1 (PS1) transgenic mice, were investigated based on our previous studies. Thirty-three 6-month-old male APP/PS1 mice were randomly divided into the model group (AD group), model + sham stimulation group (ADST group) and stimulation group (ADT group). Eleven 6-month-old male C57 wild-type mice were randomly selected as a control group (CTL group). The ADT group received 10 AtDCS sessions. The Morris water maze (MWM) task and novel object recognition (NOR) task were used to test mouse memory. Nissl staining, Western blot (WB), immunohistochemistry and immunofluorescence staining of β-amyloid (Aβ 42), glial fibrillary acidic protein (GFAP) and NF200 were conducted for pathological analysis. The ADT group and the CTL group had a shorter escape latency and more platform-region crossings than the AD group and ADST group in the MWM. There was no significant difference in the discrimination index among the groups in the NOR task. Pathological analysis showed visible differences between the AD group and ADT group. This study revealed that earlystage APP/PS1 transgenic mice did not show recognition memory impairment. AtDCS effectively improved spatial learning and memory in the early-stage APP/PS1 transgenic mouse model of AD, alleviating Aβ burden and having a protective effect on neurons. AtDCS could improve AD-related symptoms by activating many glial cells to promote the degradation and clearance of Aβ or directly affecting production and degradation of Aβ to reduce glial activation. AtDCS is an effective means of early intervention in the early stage of AD.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 93%

Section: Anodal Transcranial Direct Current Stimulationmentioning

confidence: 99%

See 2 more Smart Citations

Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice

Luo

Yang

et al. 2020

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…tDCS of the DLPFC and temporal regions has also shown to improve neurocognitive function in AD patients (213). In rat models of AD, tDCS has shown to increase hippocampal acetylcholine, choline acetyltransferase and glial fibrillary acidic protein expression (218,219).…”

Section: Noninvasive Neuromodulationmentioning

confidence: 99%

Deep Brain Stimulation for Alzheimer’s Disease: Tackling Circuit Dysfunction

Lam

Lee

Liu

et al. 2021

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia

Akçay,

Aslan,

Kipmen Korgun

et al. 2023

J of Neuroscience Research

View full text Add to dashboard Cite

This study aimed to assess the focal cerebral ischemia‐induced changes in learning and memory together with glutamatergic pathway in rats and the effects of treatment of the animals with transcranial Direct Current Stimulation (tDCS). One hundred male rats were divided into five groups as sham, tDCS, Ischemia/Reperfusion (IR), IR + tDCS, and IR + E‐tDCS groups. Learning, memory, and locomotor activity functions were evaluated by behavioral experiments in rats. Glutamate and glutamine levels, alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionate receptor (AMPAR1), N‐Methyl‐D‐Aspartate receptors (NMDAR1 and NMDAR2A), vesicular glutamate transporter‐1 (VGLUT‐1), and excitatory amino acid transporters (EAAT1‐3) mRNA expressions in hippocampus tissues were measured. Ischemic areas were analyzed by TTC staining. The increase was observed in IR + tDCS, and IR + E‐tDCS groups compared to the IR group while a significant decrease was observed in IR group compared to the sham in the locomotor activity, learning, and memory tests. While glutamate and glutamine levels, AMPAR1, NMDAR1, NMDAR2A, VGLUT1, and EAAT1 mRNA expressions were significantly higher in IR group compared to the sham group, it was found to be significantly lower in IR + tDCS and IR + E‐tDCS groups compared to the IR group. EAAT2 and EAAT3 mRNA expressions were significantly higher in IR + tDCS and IR + E‐tDCS groups compared to the IR group. Ischemic areas were significantly decreased in IR + tDCS and IR + E‐tDCS groups compared to the IR group. Current results suggest that tDCS application after ischemia improves learning and memory disorders and these effects of tDCS may be provided through transporters that regulate glutamate levels.

show abstract

After-effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer’s disease

Cited by 20 publications

References 37 publications

Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice

Anodal Transcranial Direct Current Stimulation Can Improve Spatial Learning and Memory and Attenuate Aβ42 Burden at the Early Stage of Alzheimer’s Disease in APP/PS1 Transgenic Mice

Deep Brain Stimulation for Alzheimer’s Disease: Tackling Circuit Dysfunction

Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia

Contact Info

Product

Resources

About