Abstract-The 1994 to 1997 administrative data on 40 450 elderly Medicare beneficiaries and general population of 2 states were used to measure "case mortality" (deaths attributable to any cause among cases of acute stroke), "case fatality" (deaths caused by cerebrovascular diseases among cases of acute stroke), and "population mortality" (deaths caused by stroke in the elderly general population). Mortality was higher in men than in women according to all measures except population mortality caused by subarachnoid hemorrhage. There was no sex difference in 1-year case fatality. One-year all-cause mortality among cases of nonhemorrhagic stroke or all types of stroke was higher in men than in women. Similar sex differences were found in 4-year population mortality caused by nonhemorrhagic stroke or all types of stroke combined. The 3 measures differed with respect to sex difference in stroke mortality. How stroke is defined and how mortality is measured does affect sex difference. Key Words: measurement Ⅲ sex difference Ⅲ stroke mortality D isparity in the outcome of chronic diseases may be a useful indicator of an opportunity for improving preventive or therapeutic care. The natural history of stroke has been studied by many researchers who have found age, sex, and race differences in mortality.Some studies of stroke mortality did not find a significant sex difference 1-3 ; others found a relatively higher risk among men 4,5 or among women. 6 -8 Some of these investigations studied mortality associated with only 1 type of stroke. 5,7 Many investigations studied mortality from all types of stroke combined. Two of the 3 studies of sex difference in mortality caused by nonhemorrhagic stroke in the general population found increased risk among women, 6,8 whereas 2 of the 3 corresponding studies that measured case fatality rates among patients with acute stroke found increased risk among men. 4,5 There are many reasons for discrepancy between these studies with respect to the magnitude and the direction of sex difference in stroke mortality. This study addressed 2 factors-how stroke was defined and how mortality was measured-by estimating 3 different measures of sex-specific stroke mortality in the same geographically defined population during the same time period. The objective was to determine the effect of using different measures on sex difference in stroke mortality.
Materials and MethodsThe measures of stroke mortality used in this study were (a) 1-year case mortality defined as deaths attributable to any cause among cases of acute stroke, (b) 1-year case fatality defined as deaths caused by cerebrovascular diseases among cases of acute stroke, and (c) 4-year population mortality defined as deaths caused by stroke in the general population in a 4-year period. The study cohort was 40 450 fee-for-service Medicare beneficiaries aged 65 to 99 years who were hospitalized in Indiana and Kentucky for acute stroke from January 1, 1994 to December 31, 1996. Medicare administrative data were used to identify the demograph...