Aflatoxins in cosmetics containing substrates for aflatoxin-producing fungi

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

“…and aflatoxins of animal derivative foods (eggs [11], milk [12,13], human maternal milk [14], cheese [15,16], hens breast [17], liver [18], sausages [19], pâté [11], etc.). Many cosmetics have aflatoxins from their vegetable sources (almond oils [20] and cosmetic creams [21], hair dyes [22] made from chili pepper, etc.) and AFs can enter through the skin or the scalp.…”

“…The bond changes that conversion. AFB 1 to AFB 2 are well studied [32,34] and the biotransformation and biosynthetic routes of AFB 1 have been previously described [18][19][20][21]. Aflatoxins damage the digestive system and the active carcinogen AFB 1 formamido-pyrimidine (AFB 1 -FAPY adduct) has been recovered, identified and quantified in cancer tumors from the liver, intestines, colon and rectum [35]; and has also been recovered in cervical cancer [36], the pancreas and malignant human breast tumors [35].…”

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

“…and aflatoxins of animal derivative foods (eggs [11], milk [12,13], human maternal milk [14], cheese [15,16], hens breast [17], liver [18], sausages [19], pâté [11], etc.). Many cosmetics have aflatoxins from their vegetable sources (almond oils [20] and cosmetic creams [21], hair dyes [22] made from chili pepper, etc.) and AFs can enter through the skin or the scalp.…”

“…The bond changes that conversion. AFB 1 to AFB 2 are well studied [32,34] and the biotransformation and biosynthetic routes of AFB 1 have been previously described [18][19][20][21]. Aflatoxins damage the digestive system and the active carcinogen AFB 1 formamido-pyrimidine (AFB 1 -FAPY adduct) has been recovered, identified and quantified in cancer tumors from the liver, intestines, colon and rectum [35]; and has also been recovered in cervical cancer [36], the pancreas and malignant human breast tumors [35].…”

Refined Solution Structure of 8,9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the Complementary Strand of an Oligodeoxynucleotide Duplex As Determined by 1H NMR

“…This mycotoxin is of worldwide health concern because of the potential contamination of the food supply. Epidermal absorption of AFBi from contaminated cosmetic products may also pose a risk (El-Dessouki, 1992). AFBi is a mutagen in several tester strains of bacteria (McCann et al, 1975), it is a hepatocarcinogen in experimental animals (Busby & Wogan, 1984; McMahon et al, 1990), and epidemiological studies suggest that it causes cancer in humans (Busby & Wogan, 1984;Groopman et al, 1988;Wogan, 1992).…”

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

“…and aflatoxins of animal derivative foods (eggs [11], milk [12,13], human maternal milk [14], cheese [15,16], hens breast [17], liver [18], sausages [19], pâté [11], etc.). Many cosmetics have aflatoxins from their vegetable sources (almond oils [20] and cosmetic creams [21], hair dyes [22] made from chili pepper, etc.) and AFs can enter through the skin or the scalp.…”

“…The bond changes that conversion. AFB 1 to AFB 2 are well studied [32,34] and the biotransformation and biosynthetic routes of AFB 1 have been previously described [18][19][20][21]. Aflatoxins damage the digestive system and the active carcinogen AFB 1 formamido-pyrimidine (AFB 1 -FAPY adduct) has been recovered, identified and quantified in cancer tumors from the liver, intestines, colon and rectum [35]; and has also been recovered in cervical cancer [36], the pancreas and malignant human breast tumors [35].…”

Refined Solution Structure of 8,9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the Complementary Strand of an Oligodeoxynucleotide Duplex As Determined by 1H NMR

“…This mycotoxin is of worldwide health concern because of the potential contamination of the food supply. Epidermal absorption of AFBi from contaminated cosmetic products may also pose a risk (El-Dessouki, 1992). AFBi is a mutagen in several tester strains of bacteria (McCann et al, 1975), it is a hepatocarcinogen in experimental animals (Busby & Wogan, 1984; McMahon et al, 1990), and epidemiological studies suggest that it causes cancer in humans (Busby & Wogan, 1984;Groopman et al, 1988;Wogan, 1992).…”

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

“…and aflatoxins of animal derivative foods (eggs [11], milk [12,13], human maternal milk [14], cheese [15,16], hens breast [17], liver [18], sausages [19], pâté [11], etc.). Many cosmetics have aflatoxins from their vegetable sources (almond oils [20] and cosmetic creams [21], hair dyes [22] made from chili pepper, etc.) and AFs can enter through the skin or the scalp.…”

“…The bond changes that conversion. AFB 1 to AFB 2 are well studied [32,34] and the biotransformation and biosynthetic routes of AFB 1 have been previously described [18][19][20][21]. Aflatoxins damage the digestive system and the active carcinogen AFB 1 formamido-pyrimidine (AFB 1 -FAPY adduct) has been recovered, identified and quantified in cancer tumors from the liver, intestines, colon and rectum [35]; and has also been recovered in cervical cancer [36], the pancreas and malignant human breast tumors [35].…”

Refined Solution Structure of 8,9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the Complementary Strand of an Oligodeoxynucleotide Duplex As Determined by 1H NMR

“…This mycotoxin is of worldwide health concern because of the potential contamination of the food supply. Epidermal absorption of AFBi from contaminated cosmetic products may also pose a risk (El-Dessouki, 1992). AFBi is a mutagen in several tester strains of bacteria (McCann et al, 1975), it is a hepatocarcinogen in experimental animals (Busby & Wogan, 1984; McMahon et al, 1990), and epidemiological studies suggest that it causes cancer in humans (Busby & Wogan, 1984;Groopman et al, 1988;Wogan, 1992).…”