Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications

Dai, Chongshan; Tian, E; Hao, Zhihui; Tang, Shusheng; Wang, Zhanhui; Sharma, Gaurav; Jiang, Haiyang; Shen, Jianzhong

doi:10.3390/antiox11102031

Cited by 42 publications

(40 citation statements)

References 175 publications

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“…Flavonoids present in PCP are proved for antiviral capability [ 44 , 57 , 58 ], so PCP could be included in medicinal preparation of acute liver disease (acute viral hepatitis, chronic active viral hepatitis, and hepatitis B virus) [ 6 , 28 , 59 ] interfering with viral replication [ 1 , 60 ]. Similarly, gallic acid also protects the liver from viral infections [ 61 ]; similarly, flavonoids also affected the indices of TNF- α , IL-6, and IL-1 β in infection [ 56 ].…”

Section: Clinical and Comparative Activitiesmentioning

confidence: 99%

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

Nabi

Ahmed

Tao

et al. 2023

BioMed Research International

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Traditional Chinese medicines (TCM) play an important role in the control and treatment of several animal diseases. Penthorum chinense Pursh (PCP) is a famous plant for its use in traditional medication practice and therapeutic effects in numerous pathological conditions. In China, PCP is utilized for both food and medication due to numerous bioactivities. PCP is widely administered in prevention and treatment of traumatic injury, edema, and liver diseases with functions of reducing swelling, support diuresis, blood stasis, and mitigation symptoms of excessive alcohol intake. Recently, PCP highlighted for research trials in various fields including pharmacology, pharmacognosy, cosmeceuticals, nutraceuticals, and pharmaceuticals due to medicinal significance with less toxicity and an effective ethnomedicine in veterinary practice. PCP contains diverse important ingredients such as flavonoids, organic acids, coumarins, lignans, polyphenols, and sterols that are important bioactive constituents of PCP exerting the therapeutic benefits and organ-protecting effects. In veterinary, PCP extract, compound, and phytochemicals/biomolecules significantly reversed the liver and kidney injuries, via antioxidation, oxidative stress, apoptosis, mitochondrial signaling pathways, and related genes. PCP water extract and compounds also proved in animal and humans’ clinical trial for their hepatoprotective, antiaging, nephroprotective, anti-inflammatory, antidiabetic, antibacterial, antiapoptotic, immune regulation, and antioxidative stress pathways. This updated review spotlighted the current information on efficiency and application of PCP by compiling and reviewing recent publications on animal research. In addition, this review discussed the toxicology, traditional use, comparative, and clinical application of PCP in veterinary practices to authenticate and find out new perspectives on the research and development of this herbal medicine.

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Section: Clinical and Comparative Activitiesmentioning

confidence: 99%

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

Nabi

Ahmed

Tao

et al. 2023

BioMed Research International

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“…To make matters worse, it is difficult to remove AFB 1 by conventional disinfection or sterilization . Despite advancements in food safety and feed security over the past decade, developing countries continue to experience high levels of AFB 1 contamination . AFB 1 -associated health effects are widespread in China, India, and the USA …”

Section: Introductionmentioning

confidence: 99%

“…5 Despite advancements in food safety and feed security over the past decade, developing countries continue to experience high levels of AFB 1 contamination. 6 AFB 1 -associated health effects are widespread in China, India, and the USA. 7 A recent increase in male infertility has been associated with the increased occurrence of AFB 1 in food and environment.…”

Section: Introductionmentioning

confidence: 99%

Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Huang,

Zhang,

Miao

et al. 2024

J. Agric. Food Chem.

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The worldwide prevalence of Aflatoxin B1 (AFB 1 ), which contaminates feedstock and food, is on the rise. AFB 1 inhibits testosterone (T) biosynthesis, but the mechanism is not yet clear. By establishing in vivo and in vitro models, this study found the number of Leydig cells (LCs), T content, and the expression of T biosynthesis key enzymes were suppressed after AFB 1 treatment. AFB 1 exposure also increased reactive oxygen species (ROS) and promoted mitochondrial injury and mitochondrial pathway apoptosis. Moreover, the AMPK signaling pathway was activated, and using an AMPK inhibitor relieved apoptosis and the suppressed T biosynthesis key enzymes of LCs caused by AFB 1 through regulating downstream p53 and Nur77. Additionally, adding ROS intervention could inhibit AMPK activation and alleviate the decreased T content caused by AFB 1 . In summary, AFB 1 promotes the apoptosis of LCs and inhibits T biosynthesis key enzyme expression via activating the ROS/AMPK signaling pathway, which eventually leads to T synthesis disorder.

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“…1 Emerging evidence suggests that factors like chemotherapy drugs, environmental pollutants, and biological toxins can exacerbate these neurodegenerative conditions. 2,3 Unfortunately, effective therapeutic options for these diseases remain limited, necessitating the development of novel treatment strategies. 4 Most neurodegenerative diseases share common pathological mechanisms, such as oxidative stress, mitochondrial dysfunction, neuroinflammation, autophagy, and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Thymol as a Potential Neuroprotective Agent: Mechanisms, Efficacy, and Future Prospects

Peng,

Zhang,

Sharma

et al. 2024

J. Agric. Food Chem.

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Neurodegenerative diseases pose a growing global health challenge, with limited effective therapeutic options. Mitochondrial dysfunction, oxidative stress, neuroinflammation, apoptosis, and autophagy are common underlying mechanisms in these diseases. Thymol is a phenolic monoterpene compound that has gained attention for its diverse biological properties, including antioxidant, anti-inflammatory, and immunomodulatory activities. Thymol supplementation could provide potential neuroprotection and improve cognitive deficits, depressant-like effects, learning, and memory impairments in rodents. Mechanistic investigations reveal that the neuroprotective effects of thymol involve the improvement of oxidative stress, mitochondrial dysfunction, and inflammatory response. Several signaling pathways, including mitochondrial apoptotic, NF-κB, AKT, Nrf2, and CREB/BDNF pathways are also involved. In this review, the neuroprotective effects of thymol, the potential molecular mechanisms, safety, applications, and current challenges toward development as a neuroprotective agent were summarized and discussed. We hope that this review provides valuable insights for the further development of this promising natural product as a promising neuroprotective agent.

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Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications

Cited by 42 publications

References 175 publications

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

Aflatoxin B1-Induced Testosterone Biosynthesis Disorder via the ROS/AMPK Signaling Pathway in Male Mice

Thymol as a Potential Neuroprotective Agent: Mechanisms, Efficacy, and Future Prospects

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