Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research

Quality of Life in People with Multiple Sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study

“…Although the mental health of the Slifka Study participants was significantly better than people with depression, it was significantly worse than that of the general population and people with hypertension, recent myocardial infarction, and Type II diabetes. This is consistent with other studies that have demonstrated the frequency of depression in MS compared to the general population and other medical conditions (Minden, Orav and Reich, 1987;Minden and Schiffer, 1990;Goldman Consensus Group, 2005) and with other comparisons using the SF-12 (Nortvedt, Riise, Myhr, and Nyland, 2000). In addition, our findings of a 16-point difference in PCS scores between people with MS and people with depression and that only 10.8% of Slifka participants "felt blue" a good bit of the time or often, are consistent with the literature describing depression in MS as moderate and closer to the symptom profile of dysthymia than to that of major depressive disorder (Minden, Orav and Reich, 1987).…”

Quality of Life in People with Multiple Sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study

“…Although the mental health of the Slifka Study participants was significantly better than people with depression, it was significantly worse than that of the general population and people with hypertension, recent myocardial infarction, and Type II diabetes. This is consistent with other studies that have demonstrated the frequency of depression in MS compared to the general population and other medical conditions (Minden, Orav and Reich, 1987;Minden and Schiffer, 1990;Goldman Consensus Group, 2005) and with other comparisons using the SF-12 (Nortvedt, Riise, Myhr, and Nyland, 2000). In addition, our findings of a 16-point difference in PCS scores between people with MS and people with depression and that only 10.8% of Slifka participants "felt blue" a good bit of the time or often, are consistent with the literature describing depression in MS as moderate and closer to the symptom profile of dysthymia than to that of major depressive disorder (Minden, Orav and Reich, 1987).…”

Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis

“…A finding that was not expected was that episodes were associated with intense reports of subjective emotional experience that were stronger than those induced by films. This finding is notably opposite to the relationship we hypothesized based on much of the pathological laughing and crying literature, which often depicts pathological laughing and crying as being unrelated, or even opposite to how the patient is feeling (Gallagher, 1989;Minden and Schiffer, 1990), although some prior authors have anticipated this finding (Wilson, 1924;Wortzel et al, 2008).…”

Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample

“…Over half (51%) of our study sample of individuals with MS in eastern Washington state scored in the range of clinically significant depressive symptoms (CES-D Ն16). Consistent with other research on depression and MS, the prevalence of depressive symptoms in this community-dwelling MS population is higher compared to the general population and other groups of people with disabilities [1][2][3][4][5]10]. Treatment of depression in the MS population has the potential to ease suffering and reduce associated functional limitations.…”

Quality of Life in People with Multiple Sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study

“…Although the mental health of the Slifka Study participants was significantly better than people with depression, it was significantly worse than that of the general population and people with hypertension, recent myocardial infarction, and Type II diabetes. This is consistent with other studies that have demonstrated the frequency of depression in MS compared to the general population and other medical conditions (Minden, Orav and Reich, 1987;Minden and Schiffer, 1990;Goldman Consensus Group, 2005) and with other comparisons using the SF-12 (Nortvedt, Riise, Myhr, and Nyland, 2000). In addition, our findings of a 16-point difference in PCS scores between people with MS and people with depression and that only 10.8% of Slifka participants "felt blue" a good bit of the time or often, are consistent with the literature describing depression in MS as moderate and closer to the symptom profile of dysthymia than to that of major depressive disorder (Minden, Orav and Reich, 1987).…”

Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis

“…A finding that was not expected was that episodes were associated with intense reports of subjective emotional experience that were stronger than those induced by films. This finding is notably opposite to the relationship we hypothesized based on much of the pathological laughing and crying literature, which often depicts pathological laughing and crying as being unrelated, or even opposite to how the patient is feeling (Gallagher, 1989;Minden and Schiffer, 1990), although some prior authors have anticipated this finding (Wilson, 1924;Wortzel et al, 2008).…”

Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample

“…Over half (51%) of our study sample of individuals with MS in eastern Washington state scored in the range of clinically significant depressive symptoms (CES-D Ն16). Consistent with other research on depression and MS, the prevalence of depressive symptoms in this community-dwelling MS population is higher compared to the general population and other groups of people with disabilities [1][2][3][4][5]10]. Treatment of depression in the MS population has the potential to ease suffering and reduce associated functional limitations.…”

Quality of Life in People with Multiple Sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study

“…Although the mental health of the Slifka Study participants was significantly better than people with depression, it was significantly worse than that of the general population and people with hypertension, recent myocardial infarction, and Type II diabetes. This is consistent with other studies that have demonstrated the frequency of depression in MS compared to the general population and other medical conditions (Minden, Orav and Reich, 1987;Minden and Schiffer, 1990;Goldman Consensus Group, 2005) and with other comparisons using the SF-12 (Nortvedt, Riise, Myhr, and Nyland, 2000). In addition, our findings of a 16-point difference in PCS scores between people with MS and people with depression and that only 10.8% of Slifka participants "felt blue" a good bit of the time or often, are consistent with the literature describing depression in MS as moderate and closer to the symptom profile of dysthymia than to that of major depressive disorder (Minden, Orav and Reich, 1987).…”

Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis

“…A finding that was not expected was that episodes were associated with intense reports of subjective emotional experience that were stronger than those induced by films. This finding is notably opposite to the relationship we hypothesized based on much of the pathological laughing and crying literature, which often depicts pathological laughing and crying as being unrelated, or even opposite to how the patient is feeling (Gallagher, 1989;Minden and Schiffer, 1990), although some prior authors have anticipated this finding (Wilson, 1924;Wortzel et al, 2008).…”

Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample

“…Over half (51%) of our study sample of individuals with MS in eastern Washington state scored in the range of clinically significant depressive symptoms (CES-D Ն16). Consistent with other research on depression and MS, the prevalence of depressive symptoms in this community-dwelling MS population is higher compared to the general population and other groups of people with disabilities [1][2][3][4][5]10]. Treatment of depression in the MS population has the potential to ease suffering and reduce associated functional limitations.…”