Affective and cognitive correlates of PTSD: Electrocortical processing of threat and perseverative errors on the WCST in combat-related PTSD

DiGangi, Julia A.; Kujawa, Autumn; Aase, Darrin M.; Babione, Joseph M.; Schroth, Christopher; Levy, David M.; Kennedy, Amy E.; Greenstein, Justin E.; Proescher, Eric; Walters, Robert P.; Passi, Holly; Langenecker, Scott A.; Phan, K. Luan

doi:10.1016/j.pnpbp.2017.01.004

Cited by 11 publications

(11 citation statements)

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“…IQ is lower. WCST showed an implementation flaw, the number of errors was used to assess post-traumatic stress disorder in prisoners of war, and more persistent WCST errors were observed in severe cases [22] [23]. The results of this study show more total errors in patients with post-traumatic stress disorder.…”

Section: Logistic Regression Analysis Of Various Factorsmentioning

confidence: 64%

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Bei¹,

Guo²,

Huang³

et al. 2019

WJNS

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Objective: To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan Province. Methods: Essen trauma inventory (ETI), clinician administered post-traumatic stress disorders scale, (CAPS), tower of Hanoi (TOH), wsiconsin card sorting test (WCST), trail making test (TMT) and wechsler adult intelligence scale revised China (WAIS-RC) were used to investigate patients with PTSD and healthy volunteers (control group). PCR and PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results: The ETI score, total PTSD score and TMT time of Li nationality patients with PTSD were significantly higher than those of Han nationality patients with PTSD, and the IQ of comprehension and operation in WAIS-RC was significantly lower than that of Han nationality patients with PTSD (P < 0.05). The ETI score, total PTSD score and TMT time of 5-HTTLPR genotype in Li nationality and Han nationality patients with PTSD were significantly higher than those of LL genotype, and the perception, calculation and block diagram in WAIS-RC were significantly lower than those of LL genotype patients (P < 0.05). Conclusions: The SS genotype can increase the risk of PTSD in Li nationality and Han nationality people in Hainan. LL genotype is associated with PTSD of Li and Han nationalities in Hainan, and is an important protective factor for PTSD of Li and Han nationalities in Hainan.

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Section: Logistic Regression Analysis Of Various Factorsmentioning

confidence: 64%

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Bei¹,

Guo²,

Huang³

et al. 2019

WJNS

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“…The relationship between cognitive and emotional information-processing of stimuli in the brain presents a hallmark characteristic of PTSD and is reflected in cognitive and affective dysregulations [6][7][8]. In their review, Aupperle et al point to the importance of executive dysfunction, attention, working memory disturbances, sustained attention, inhibition, and flexibility in and switching of attention.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, it has been shown that impaired inhibition affects the controllability of emotional cues [8,15], and thus might lead to symptoms of re-experiencing [9]. Moreover, a study with veterans demonstrated that only interactions between emotional reactivity and impairment in executive functioning were associated with more severe PTSD symptoms, but none of the variables alone [6]. Finally.…”

Section: Introductionmentioning

confidence: 99%

“…In light of these findings combining information from cognitive and emotion processing might provide a better understanding of how PTSD develops after trauma exposure. Since studies suggest that interactions between specific facets on various stages facilitate the exacerbation of PTSD symptoms, (c.f [6,9,13,15]. ), an analysis approach is required that can accommodate complex interactions of highly-dimensional data.…”

Section: Introductionmentioning

confidence: 99%

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Utilization of machine learning to test the impact of cognitive processing and emotion recognition on the development of PTSD following trauma exposure

Augsburger

Galatzer‐Levy

2020

BMC Psychiatry

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Background: Though lifetime exposure to traumatic events is significant, only a minority of individuals develops symptoms of posttraumatic stress disorder (PTSD). Post-trauma alterations in neurocognitive and affective functioning are likely to reflect changes in underlying brain networks that are predictive of PTSD. These constructs are assumed to interact in a highly complex way. The aim of this exploratory study was to apply machine learning models to investigate the contribution of these interactions on PTSD symptom development and identify measures indicative of circuit related dysfunction. Methods: N = 94 participants admitted to the emergency room of an inner-city hospital after trauma exposure completed a battery of neurocognitive and emotional tests 1 month after the incident. Different machine learning algorithms were applied to predict PTSD symptom severity and clusters after 3 months based. Results: Overall, model accuracy did not differ between PTSD clusters, though the importance of cognitive and emotional domains demonstrated both key differences and overlap. Alterations in higher-order executive functioning, speed of information processing, and processing of emotionally incongruent cues were the most important predictors. Conclusions: Data-driven approaches are a powerful tool to investigate complex interactions and can enhance the mechanistic understanding of PTSD. The study identifies important relationships between cognitive processing and emotion recognition that may be valuable to predict and understand mechanisms of risk and resilience responses to trauma prospectively.

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“…Anger and aggression problems in veterans with PTSD are associated with increased threat reactivity, an inability to regulate arousal, and a lowered threshold for perceiving threat stimuli, compared to control veterans (Heesink et al, 2017). Studies of PTSD using both angry and fearful expression faces have found mixed results, such as increased activations of the amygdala for fearful but not angry faces (Simmons et al, 2011), larger early event-related potential components to angry (P1 and P2 amplitudes) and fear (P2) faces in patients with high symptom levels (Zuj et al, 2017), and slower response times and worse performance for angry relative to fearful and happy expression faces (DiGangi et al, 2017b).…”

Section: Introductionmentioning

confidence: 99%

Angry and Fearful Face Conflict Effects in Post-traumatic Stress Disorder

Ashley

Swick

2019

Front. Psychol.

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In the presence of threatening stimuli, post-traumatic stress disorder (PTSD) can manifest as hypervigilance for threat and disrupted attentional control. PTSD patients have shown exaggerated interference effects on tasks using trauma-related or threat stimuli. In studies of PTSD, faces with negative expressions are often used as threat stimuli, yet angry and fearful facial expressions may elicit different responses. The modified Eriksen flanker task, or the emotional face flanker, has been used to examine response interference. We compared 23 PTSD patients and 23 military controls on an emotional face flanker task using angry, fearful and neutral expressions. Participants identified the emotion of a central target face flanked by faces with either congruent or incongruent emotions. As expected, both groups showed slower reaction times (RTs) and decreased accuracy on emotional target faces, relative to neutral. Unexpectedly, both groups showed nearly identical interference effects on fearful and neutral target trials. However, post hoc testing suggested that PTSD patients showed faster RTs than controls on congruent angry faces (target and flanker faces both angry) relative to incongruent, although this finding should be interpreted with caution. This possible RT facilitation effect with angry, but not fearful faces, also correlated positively with self-report measures of PTSD symptoms. These results suggest that PTSD patients may be more vigilant for, or primed to respond to, the appearance of angry faces, relative to fearful, but further study is needed.

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Affective and cognitive correlates of PTSD: Electrocortical processing of threat and perseverative errors on the WCST in combat-related PTSD

Cited by 11 publications

References 59 publications

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Utilization of machine learning to test the impact of cognitive processing and emotion recognition on the development of PTSD following trauma exposure

Angry and Fearful Face Conflict Effects in Post-traumatic Stress Disorder

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Affective and cognitive correlates of PTSD: Electrocortical processing of threat and perseverative errors on the WCST in combat-related PTSD

Cited by 11 publications

References 59 publications

Correlation Analysis of 5-&lt;i&gt;HTTLPR&lt;/i&gt; Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Correlation Analysis of 5-&lt;i&gt;HTTLPR&lt;/i&gt; Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Utilization of machine learning to test the impact of cognitive processing and emotion recognition on the development of PTSD following trauma exposure

Angry and Fearful Face Conflict Effects in Post-traumatic Stress Disorder

Contact Info

Product

Resources

About

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Correlation Analysis of 5-<i>HTTLPR</i> Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province