Aerobic exercise blocks interleukin-6 levels and germ cell apoptosis in obese rats

Li, N.-C.; Wei, Xiu-Xia; Hu, Yulong; Hou, Xianzhi; Xu, Huaxi

doi:10.1111/and.12880

Cited by 11 publications

(9 citation statements)

References 16 publications

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“…Excessive apoptosis of spermatogenic cells would damage spermatogenesis leading to infertility [54]. Increased evidence indicates that altering testis morphological structure and increases in germ cell apoptosis were present in high-fat diet induced obesity or lipid metabolism disorder [55]. Further, testosterone provides protection against apoptosis of germ cell [56].…”

Section: Discussionmentioning

confidence: 99%

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

Luo

Huang

et al. 2019

Molecules

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Soy isoflavones (SIF) are biologically active compounds of non-steroidal and phenolic properties that are richly present in soybeans, which can reduce the body weight and blood lipids of obese animals. Recently, SIF have been reported to affect reproductive ability in obese male rats. However, the specific mechanism has not been well defined. The aim of the current study was to study the possible mechanisms for the effect of SIF administration on obesity induced spermatogenic defects. Obese rats model induced by high-fat diets were established and gavage treated with 0, 50,150 or 450 mg of SIF/kg body weight/day for 4 weeks. Here, our research shows that obesity resulted in spermatogenic degeneration, imbalance of reproductive hormone, testicular oxidative stress and germ cell apoptosis, whereas evidently recovery effects were observed at 150 and 450 mg/kg SIF. We also have discovered that 150 and 450 mg/kg SIF can activate Nrf2/HO-1 pathway in control of Bcl-2, BAX and cleaved caspase-3 expression with implications in antioxidant protection. Our study indicates the potential mechanism of SIF regulating spermatogenic function in obese rats, and provides a scientific experimental basis for the regulation of biological function of obese male reproductive system by SIF.

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Section: Discussionmentioning

confidence: 99%

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

Luo

Huang

et al. 2019

Molecules

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“…It is also known that obesity causes apoptosis (Li et al, 2018). In an investigation carried out by Sa-nguanmoo et al (2018), it was detected that obesity insulin resistance developed with an increase in systemic inflammation, brain mitochondrial dysfunction, rise in brain apoptosis, and disruption and cognitive reduction in hippocampal plasticity in rats fed a high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

The effects of feeding obese rats with bee bread on leptin and ghrelin expression

Doğanyiğit¹,

Yakan²,

Soylu³

et al. 2020

Turk J Zool

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Obesity is an important public health problem and a risk factor for many chronic diseases, and its prevalence is increasing rapidly. In recent years there has been interest in the impact of nutrients on obesity and this has been addressed as a research topic. Bee bread is a bee product that has recently attracted attention with its macro-and micronutrients and the enzymes and biocomponents it contains. Although there are many studies on the biological properties and effects of bee bread, its effect on obesity with leptin and ghrelin has not been investigated. In this study, 40 Sprague-Dawley adult female rats were separated into 4 groups after they had become obese by having been fed with commercial high-fat food. While the 1st group was the control, the 2nd group was the obese control and bee bread was given to the 3rd and 4th groups (100 and 200 mg/kg bw/day), and in the 5th group metformin (300 mg/kg/day) was provided. Histopathological and immunohistochemical analysis was performed in hypothalamus tissues, and biochemical analyses were conducted of blood samples and hypothalamus tissues by ELISA methods. The apoptotic cell level was determined by the TUNEL method. The results of the immunohistochemical assessment of the hypothalamus tissues were consistent, and the levels of leptin and ghrelin were inversely correlated in the samples. Biochemical analysis showed that MDA levels increased with obesity whereas differences in SOD, CAT, and XOD levels were not statistically significant. Bee bread improved lipid peroxidation caused by obesity. It was shown that obesity caused apoptotic cell count increase and bee bread decreased it. Bee bread administration (200 mg/kg/day) had positive effects on weight control and other parameters.

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“…In this model, MetS led to inflammatory responses in the testis involving increase of expression IL-6R mRNA and IL-1R mRNA (the receptors of IL-1 and IL-6 pro-inflammatory cytokines). Data from many studies indicate that IL-1 (Hirik et al 2018) and IL-6 (Li et al 2018, Wang et al 2018) are integrated in a complex network of endocrine and local regulatory mechanisms within the seminiferous epithelium. The results of the present study suggest that MetS promotes inflammation in testis and elevates IL-6R and IL-1R level leading to germ cells apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats

Rahali

Dallagi

Hupkens

et al. 2020

Archives of Physiology and Biochemistry

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Context: Metabolic syndrome (MetS) is a clustering of several physiological alterations. Objective: This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. Materials and methods: We developed a MetS rodent model using high-sugar and high-fat diet. Results: MetS rats showed severe disorders in sperm parameters. Interestingly, a significant increase in malondialdehyde level and a decrease in the antioxidant activities were observed. Moreover, qRT-PCR analysis showed Bax down-regulation and Bcl-2 up-regulation. A decrease in testosterone level was identified, correlated with the CYP11A1, CYP17A1 and 17b HSD testicular marker down-regulation. Finally, MetS rats showed an up-regulation of pro-inflammatory cytokines receptors IL-1R and IL-6R. Conclusion: MetS induced severe testis toxicity in male rats. Mets markedly distorted sperm parameters, inhibited the transcription of steroidogenic enzymes and led to oxidative stress, inflammation, and alteration of Bax/Bcl-2 ratioin testicular tissues.

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Aerobic exercise blocks interleukin-6 levels and germ cell apoptosis in obese rats

Cited by 11 publications

References 16 publications

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

The effects of feeding obese rats with bee bread on leptin and ghrelin expression

Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats

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