Æðaflækjur í heila - yfirlitsgrein

Sveinsson, Ólafur; Ólafsson, Ingvar Hákon; Valdimarsson, Einar Már

doi:10.17992/lbl.2016.09.96

Cited by 1 publication

(1 citation statement)

References 34 publications

(51 reference statements)

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“…Cerebral infarction is a type of ischemic stroke resulting from a blockage in the blood vessels supplying blood to the brain. Acute cerebral infarction (ACI) is highly debilitating or lethal, and is characterized by high rates of disability, dementia, and even death [2,3]. Currently, recombinant tissue-type plasminogen activator (rt-PA) is recommended as one of the most effective methods in the treatment of ACI within the limited 4.5-h timeframe [4].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) in Patients with Hyperacute Cerebral Infarction Receiving rt-PA Intravenous Thrombolytic Therapy

et al. 2016

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BackgroundThe aim of this study was to investigate the potential value of apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in the prognosis of patients with hyperacute cerebral infarction (HCI) receiving intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA).Material/MethodsFrom June 2012 to June 2015, 58 cases of HCI (<6 h) undergoing rt-PA intravenous thrombolytic therapy (thrombolysis group) and 70 cases of HCI (<6 h) undergoing conventional antiplatelet and anticoagulant therapy (control group) in the same period were collected. DWI was conducted on all the subjects, and ADC maps were generated with Functool software to quantify ADC value. The clinical outcomes of HCI patients were observed for 3 months, and prognostic factors were analyzed.ResultsBefore thrombolysis treatment, the lesion area presented high signal intensity on DWI map and low signal intensity on ADC map, and gradually weakened signal intensity on DWI map and gradually enhanced signal intensity on ADC map were observed after thrombolysis. The ADC values of the thrombolysis group were significantly higher than those of the control group after treatment (24 h, 7 d, 30 d, and 90 d) (all P<0.05), and the ADC and rADC values in the thrombolysis group gradually increased over time (all P<0.05). Multiple logistic regression analysis showed that baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline rADC value, and stroke history were the independent factors for the prognosis of HIC patients with thrombolysis (all P<0.05).ConclusionsThe values of ADC and rADC may provide guidance in the prognosis of HCI patients receiving rt-PA, and the baseline rADC value is the protective factor for the prognosis of HCI patients receiving rt-PA.

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Section: Introductionmentioning

confidence: 99%