Adverse reactions of radiotherapy for head and neck cancers. Treatment of radiation reactions in the oral cavity

Czerżyńska, Magdalena; Orłow, Paulina; Choromańska, Magdalena

doi:10.15557/pimr.2017.0005

Cited by 2 publications

(10 citation statements)

References 16 publications

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“…The studies both showed similar results in the frequency of follow-up visits. In total, 46.0% of the surveyed women say that they visit a dentist once every 6 months as compared with 42.7% of women in the study by Czerżyńska et al [1]. We observed a slightly different situation among the surveyed men, i.e., 32.8% vs. 19.4%.…”

Section: Discussioncontrasting

confidence: 69%

“…A similar study on dentophobia was conducted by Czerżyńska et al [1] in 2017, where the study group consisted of 330 patients at the Specialist Outpatient Clinics of the University Teaching Hospital in Białystok (Poland). In our survey of 232 people, 67.1% of respondents declared that they last visited a dentist up to 6 months ago.…”

Section: Discussionmentioning

confidence: 88%

“…Dentophobia is described as an intense fear of dental procedures performed by a doctor, or of doctors themselves, and it lasts until the treatment is discontinued [1]. It is a type of paralyzing fear that makes it difficult for patients to make decisions regarding a possible visit to a dentist's office or whether to cancel the visit.…”

Section: Introductionmentioning

confidence: 99%

“…The causes of this type of fear are rooted in negative childhood experiences or in the fear of pain [2]. Anxiety leads to deteriorating oral health (including professional hygiene procedures) and implies that patients go to a dentist only when they begin to feel severe pain, which is related to postponing appointments and not treating carious lesions voluntarily [1].…”

Section: Introductionmentioning

confidence: 99%

“…Although the definitions of the two terms differ from each other, they are often used as synonyms [3]. Anxiety is a mental state associated with a sense of threat that cannot be precisely defined [1]. Dental anxiety occurs in patients and also in healthcare professionals.…”

Section: Introductionmentioning

confidence: 99%

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Causes and Severity of Dentophobia in Polish Adults—A Questionnaire Study

et al. 2021

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Introduction: A phobia is defined as an irrational fear, the intensity of which is inadequate to the circumstances, and it leads to the avoidance of situations that trigger it. A person with dentophobia avoids dental treatment, even when the pain in the teeth or oral cavity exceeds their fear. Fear and anxiety are the most common emotional states experienced by patients in dental offices. The aim of the study was to determine the following: the probable causes of dentophobia, which procedures patients fear the most, and the subjective feeling of fear on a point scale. Materials and Methods: The research was conducted in the form of an anonymous online questionnaire and its printed equivalent. The survey was available from 23 January to 16 March 2020, and it was addressed to adult respondents. In total, 130 respondents and 102 dental students took part in the survey. Results: It is worthwhile emphasizing that the main reason for dentist visits (for almost one-third of men and almost one-fifth of women surveyed) is a toothache. Periodontal problems (2.2%), tooth extractions (1.8%), and prosthetic consultations (0.9%) were relatively rare reasons for the respondents to visit a dentist. The vast majority of respondents see the cause of dentophobia as being related to their previous bad experiences. The second most frequently chosen answer is anxiety, which is caused by the sounds of dental apparatus. Conclusions: Pain is the most common reason given for fear of visiting a dentist, as well as the cause of dentophobia. Pain reduction can positively affect the frequency of visits to a dentist, thus, improving the condition of the oral cavity of patients.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Causes and Severity of Dentophobia in Polish Adults—A Questionnaire Study

et al. 2021

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Effect and mechanism of action in vitro of cyclodextrin derivative nanoparticles loaded with tyroserleutide on hepatoma

Wu¹,

Hua²,

Tiantian³

et al. 2021

Nanotechnology

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In this study, a cyclodextrin derivative (R6RGD-CMβCD) nanoparticle with tumor targeting and cell penetration ability was successfully synthesized and loaded with tyroserleutide (YSL) to obtain YSL-loaded nanoparticles (YSL/R6RGD-CMβCD NPs). The characterization of these NPs revealed a smooth surfaces and an average diameter of approximately 170 nm. YSL/R6RGD-CMβCD NPs increased the NP uptake in Caco-2 cells. As regard the mechanism of action, the cell uptake was related to endocytosis mediated by reticulin and megacytosis. In addition, YSL/R6RGD-CMβCD NPs induced significantly higher cytotoxicity on tumor cells and better tumor targeting compared with the effect of CMβCD NPs. Most importantly, the good anti-cancer effect of YSL/R6RGD-CMβCD NPs might be due to the interference with the function of mitochondria. On the other hand, YSL/R6RGD-CMβCD NPs were not toxic for normal cells. Taken together, our results indicated that R6RGD-CMβCD could be considered as a nanopharmaceutical material with good tumor targeting abilities, and their combination with YSL could represent an effective anti-cancer system.

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Adverse reactions of radiotherapy for head and neck cancers. Treatment of radiation reactions in the oral cavity

Cited by 2 publications

References 16 publications

Causes and Severity of Dentophobia in Polish Adults—A Questionnaire Study

Causes and Severity of Dentophobia in Polish Adults—A Questionnaire Study

Effect and mechanism of action in vitro of cyclodextrin derivative nanoparticles loaded with tyroserleutide on hepatoma

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