Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study

Bonito, Rosuita Fratari; Oliveira, Neide Mattar de; Nishioka, Sérgio de Andrade

doi:10.1590/s0037-86822004000100002

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…The side effects of this vaccine included local allergic reactions at the injection site as well as systemic allergies and neurological complications. 3,11 As a result, the Fuenzalida vaccine was discontinued in 2007 and was replaced with a cell culture-derived vaccine. However, people are still concerned about using rabies vaccines, and the fear of side effects remains.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Protective Immunity Against Rabies in Unvaccinated Butchers Working at Dog Slaughterhouses in Northern Vietnam

Nguyen¹,

Vu²,

Nguyen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Vietnam is a rabies-endemic country where eating dog meat is customary. However, the risks of rabies transmission to dog slaughtering and processing workers have not been identified. This study aimed to determine the rabies neutralizing antibody (NTA) and risk factors in dog slaughterers to propose appropriate intervention methods for this occupational group. In 2016, a cross-sectional study on NTA against rabies virus and related factors was conducted among 406 professional dog slaughterers in Vietnam. The participants were interviewed using a structured questionnaire, and their sera were tested for rabies NTA by a rapid focus fluorescence inhibition test. Statistical algorithms were used to analyze the data. The results showed that most of the professional dog butchers (344/406 subjects, 84.7%) had no rabies NTA. Interestingly, 7.8% (29/373) had NTA without a rabies vaccination history. Over 5 years of experience as a dog butcher was positively associated with the presence of NTA in unvaccinated individuals (OR = 6.16, P = 0.001). The NTA in vaccinated butchers was present in higher titer and for longer persistence to those of other previously reported professionals, which is possibly as a result of multiple exposures to low levels of rabies virus antigens during dog slaughtering. Our study demonstrated that professional dog butchers in Vietnam are at a high risk of rabies virus infection, apart from those with common bite experiences. In countries where dog meat consumption is customary, rabies control and prevention activities should focus on safety during dog trading and slaughtering.

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Section: Discussionmentioning

confidence: 99%

Risk Factors and Protective Immunity Against Rabies in Unvaccinated Butchers Working at Dog Slaughterhouses in Northern Vietnam

Nguyen¹,

Vu²,

Nguyen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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“…The lack of myelin in tissues derived from newborn animals made the SMB vaccine less reactogenic compared to the Semple vaccine. However, research revealed that the vaccine was not free from myelin completely, and the presence of other undesirable components resulted in severe adverse reactions [36]. Hence, in unison with WHO recommendations, the national regulatory authorities across the globe decided to discontinue this vaccine after its decade's long use [37].…”

Section: Myelin-free Tissue Vaccinesmentioning

confidence: 99%

Developments in Rabies Vaccines: The Path Traversed from Pasteur to the Modern Era of Immunization

et al. 2023

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Rabies is a disease of antiquity and has a history spanning millennia ever since the first interactions between humans and dogs. The alarming fatalities caused by this disease have triggered rabies prevention strategies since the first century BC. There have been numerous attempts over the past 100 years to develop rabies vaccineswith the goal of preventing rabies in both humans and animals. Thepre-Pasteurian vaccinologists, paved the way for the actual history of rabies vaccines with the development of first generation vaccines. Further improvements for less reactive and more immunogenic vaccines have led to the expansion of embryo vaccines, tissue culture vaccines, cell culture vaccines, modified live vaccines, inactivated vaccines, and adjuvanted vaccines. The adventof recombinant technology and reverse genetics have given insight into the rabies viral genome and facilitated genome manipulations, which in turn led to the emergence of next-generation rabies vaccines, such as recombinant vaccines, viral vector vaccines, genetically modified vaccines, and nucleic acid vaccines. These vaccines were very helpful in overcoming the drawbacks of conventional rabies vaccines with increased immunogenicity and clinical efficacies. The path traversed in the development of rabies vaccines from Pasteur to the modern era vaccines, though, faced numerous challenges;these pioneering works have formed the cornerstone for the generation of thecurrent successful vaccines to prevent rabies. In the future, advancements in the scientific technologies and research focus will definitely lay the path for much more sophisticated vaccine candidates for rabies elimination.

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“…The Fuenzalida rabies vaccine was thereby developed using this technique [14]. However, the vaccine was not fully free of brain tissue components such as myelin, and severe adverse reactions were still reported [15]. An alternative approach to overcome these issues employed embryonated eggs, such as chick or duck embryos, as the media to produce rabies vaccines [12].…”

Section: Brief History Of Classical Rabies Vaccinesmentioning

confidence: 99%

Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential

Zhu

Guo

2016

Viruses

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Rabies is an acute, fatal, neurological disease that affects almost all kinds of mammals. Vaccination (using an inactivated rabies vaccine), combined with administration of rabies immune globulin, is the only approved, effective method for post-exposure prophylaxis against rabies in humans. In the search for novel rabies control and treatment strategies, live-attenuated viruses have recently emerged as a practical and promising approach for immunizing and controlling rabies. Unlike the conventional, inactivated rabies vaccine, live-attenuated viruses are genetically modified viruses that are able to replicate in an inoculated recipient without causing adverse effects, while still eliciting robust and effective immune responses against rabies virus infection. A number of viruses with an intrinsic capacity that could be used as putative candidates for live-attenuated rabies vaccine have been intensively evaluated for therapeutic purposes. Additional novel strategies, such as a monoclonal antibody-based approach, nucleic acid-based vaccines, or small interfering RNAs (siRNAs) interfering with virus replication, could further add to the arena of strategies to combat rabies. In this review, we highlight current advances in rabies therapy and discuss the role that they might have in the future of rabies treatment. Given the pronounced and complex impact of rabies on a patient, a combination of these novel modalities has the potential to achieve maximal anti-rabies efficacy, or may even have promising curative effects in the future. However, several hurdles regarding clinical safety considerations and public awareness should be overcome before these approaches can ultimately become clinically relevant therapies.

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Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study

Cited by 10 publications

References 3 publications

Risk Factors and Protective Immunity Against Rabies in Unvaccinated Butchers Working at Dog Slaughterhouses in Northern Vietnam

Risk Factors and Protective Immunity Against Rabies in Unvaccinated Butchers Working at Dog Slaughterhouses in Northern Vietnam

Developments in Rabies Vaccines: The Path Traversed from Pasteur to the Modern Era of Immunization

Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential

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