Adverse Ocular Events following COVID-19 Vaccination

Eleiwa, Taher; Gaier, Eric D.; Haseeb, Abid; ElSheikh, Reem H; Sallam, Ahmed B.; Elhusseiny, Abdelrahman M.

doi:10.1007/s00011-021-01506-6

Cited by 37 publications

(35 citation statements)

References 44 publications

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“…Santovito and Pinna previously reported on a male patient who developed sudden darkening of his visual field after receiving the BNT162b2 vaccine but were unable to comment on an etiology [133]. We have previously discussed this case elsewhere, suggesting that it may have been an optic neuropathy [14].…”

Section: Other Reportsmentioning

confidence: 88%

“…Eleiwa et al reported on a 46-year-old man who developed torsional, binocular diplopia three days after receiving the second dose of the AZD1222 vaccine [14]. Examination was consistent with a diagnosis of right trochlear (4th cranial) nerve palsy.…”

Section: Ocular Gaze Palsiesmentioning

confidence: 97%

“…We have previously discussed the mechanisms underlying optic neuropathy in the setting of vaccination. While the phenomenon is poorly studied, it has been previously posited that molecular mimicry between myelin basic protein and viral particles, epitope spreading, bystander activation, and superantigen activation all may play a role in the development of autoimmune optic neuritis following vaccination [14,[115][116][117][118][119].…”

Section: Mechanismsmentioning

confidence: 99%

“…It is thus vital to also investigate the relationship between COVID-19 vaccination and ocular complications. A considerable number of reports and retrospective case studies have reported on possible adverse effects of vaccination against COVID-19 approximately one year into the dissemination of these vaccines [14][15][16]. In this review, we seek to provide a rigorous description of these findings based on a comprehensive review and statistical analysis of the literature.…”

Section: Introductionmentioning

confidence: 99%

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Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.

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Section: Other Reportsmentioning

confidence: 88%

Section: Ocular Gaze Palsiesmentioning

confidence: 97%

Section: Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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“…Inflammation of the optic nerve, retina, uveal tract and anterior segment accounted for 9% of VAERS reports. 9 Twelve case reports of intraocular inflammation following COVID-19 vaccination were reviewed and included acute corneal graft rejection (n = 7, 7–21 days post vaccination), choroiditis (n = 1, 7 days post vaccination), uveitis (n = 4, 3–14 days post vaccination) and arteritic anterior ischemic optic neuropathy (n = 1, 2 days post vaccination). 10 A recent retrospective multicenter study reviewed all Comirnaty (BNT162b2) COVID-19 vaccination related-uveitis cases in Israel.…”

Section: Discussionmentioning

confidence: 99%