2003
DOI: 10.2337/diabetes.52.11.2805
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Abstract: Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (؉/؉) (n ‫؍‬ 55, 12 weeks old) and age-matched control db/db (؉/؊) mice (n ‫؍‬ 45) on two diets that differed only in AGE content (high [H-AGE] versus low [L-AGE] ratio, 5:1) for 3 months. Full-thickness skin wounds (1 cm) were examined histologically and for wound closure. Serum 24-h urine and skin samples were monitored for N ⑀ … Show more

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Cited by 130 publications
(101 citation statements)
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“…Similarly, the presence of AGE-RAGE complex on fibroblasts reduced the formation of collagen as a necessary compound for wound repairing [41]. The negative effect of AGE-RAGE on wound healing has been stated in animal studies using application of exogenous AGEs [16,42]. Table 1).…”
Section: Diabetic Wound Healingmentioning
confidence: 83%
“…Similarly, the presence of AGE-RAGE complex on fibroblasts reduced the formation of collagen as a necessary compound for wound repairing [41]. The negative effect of AGE-RAGE on wound healing has been stated in animal studies using application of exogenous AGEs [16,42]. Table 1).…”
Section: Diabetic Wound Healingmentioning
confidence: 83%
“…A diet rich in AGEs (535 units/mg of CML and 18 nmol/mg of methylglyoxal (MG) derivatives, during 16 weeks, where food and water intake were recorded daily for 1 week and biweekly thereafter) promoted a 53% increase of these substances in the serum of mice; on the other hand, a 7.8% decrease was registered in the low-AGE-diet-mice group (107 units/mg of CML and 3.6 nmol/mg of MG derivatives during the same time period) [99]. In another study carried out on 26 non-diabetic patients with renal insufficiency, an augmentation of CML (29%) and derivates of MG (26%) was also revealed in the blood of the group subjected to an AGE-rich diet, while in the group subjected to a low ingestion of AGEs, a reduction in CML (−34%) and MG (−35%) blood content was observed [137].…”
Section: Ages: Endogenous and Exogenous Sourcesmentioning
confidence: 99%
“…AGEs consist of a complex and heterogeneous group of molecules, whose formation begins with a non-enzymatic reaction between the carbonyl group of reducing sugars with free primary amino groups of amino acids, peptides, and proteins, or with lipids and nucleic acids [99,110,144]. This type of reaction is designated by non-enzymatic glycosylation, Maillard's reaction or also, more recently, glycation (Fig.…”
Section: Ages: Endogenous and Exogenous Sourcesmentioning
confidence: 99%
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“…AGEs/ ALEs can also originate exogenously, during heat processing of food (13)(14)(15)(16), and become incorporated in body components after intestinal absorption (17). It has now become apparent that dietary AGEs represent a significant source of circulating and tissue AGEs, manifesting similar pathogenic properties to their endogenous counterparts (17)(18)(19)(20)(21)(22)(23)(24). The restriction of the AGE content in standard mouse diets was found, among other effects, to markedly improve insulin resistance in obese db/db (ϩϩ) mice (8).…”
mentioning
confidence: 99%