Adventitial Remodeling After Coronary Arterial Injury

Shi, Yi; Pieniek, Marc; Fard, Ali; O’Brien, James E.; Mannion, John D.; Zalewski, Andrew

doi:10.1161/01.cir.93.2.340

Cited by 314 publications

(197 citation statements)

References 32 publications

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“…In contrast, the adventitia underlying PTCA-induced lesions showed clear inflammatory and fibrotic changes with a progressive accumulation of collagen, whereas the neointima was strongly positive for Alcian blue staining, as previously described. 13 At 30 days, the adventitia of PTCA-treated arteries was always thicker than that of noninjured or stented arteries (Figure 2b). …”

Section: Christen Et Al Mechanisms Of Neointima Formation 883mentioning

confidence: 93%

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

et al. 2001

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Background-To characterize the cells responsible for neointima formation after porcine coronary artery wall injury, we studied the expression of smooth muscle cell (SMC) differentiation markers in 2 models: (1) self-expanding stent implantation resulting in no or little interruption of internal elastic lamina and (2) percutaneous transluminal coronary angioplasty (PTCA) resulting in complete medial rupture and exposure of adventitia to blood components. Methods and Results-The expression of ␣-smooth muscle (SM) actin, SM myosin heavy chain isoforms 1 and 2, desmin, and smoothelin was investigated by means of immunohistochemistry and Western blots in tissues of the arterial wall collected at different time points and in cell populations cultured from these tissues. The expression of smoothelin, a marker of late SMC differentiation, was used to discriminate between SMCs and myofibroblasts. Both stent-and PTCA-induced neointimal tissues and their cultured cell populations expressed all 4 markers. The adventitial tissue underlying PTCA-induced lesions temporarily expressed ␣-SM actin, desmin, and SM myosin heavy chain isoforms, but not smoothelin. When placed in culture, adventitial cells expressed only ␣-SM actin. Conclusions-Our results suggest that SMCs are the main components of coronary artery neointima after both self-expanding stent implantation and PTCA. The adventitial reaction observed after PTCA evolves with a chronology independent of that of neointima formation and probably corresponds to a myofibroblastic reaction.

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Section: Christen Et Al Mechanisms Of Neointima Formation 883mentioning

confidence: 93%

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

et al. 2001

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“…The adventitia is a site for this autonomic innervations, 43) and it can affect the process of endoluminal atherosclerotic progression via several mechanisms. [44][45][46] Consequently, insuffi cient adaptation of the adventitia may increase the risk of end-organ dysfunctions, including infl ammation and thrombosis.…”

Section: Anatomical View Of the Effect Of The Ans On The Endotheliummentioning

confidence: 99%

The Relationship between Vascular Function and the Autonomic Nervous System

Amiya

Watanabe

Komuro

2014

Annals of Vascular Diseases

106

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Endothelial dysfunction and autonomic nervous system dysfunction are both risk factors for atherosclerosis. There is evidence demonstrating that there is a close interrelationship between these two systems. In hypertension, endothelial dysfunction affects the pathologic process through autonomic nervous pathways, and the pathophysiological process of autonomic neuropathy in diabetes mellitus is closely related with vascular function. However, detailed mechanisms of this interrelationship have not been clearly explained. In this review, we summarize fi ndings concerning the interrelationship between vascular function and the autonomic nervous system from both experimental and clinical studies. The clarifi cation of this interrelationship may provide more comprehensive risk stratifi cation and a new effective therapeutic strategy against atherosclerosis.

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“…36,37 The adventitial also may influence atherosclerosis and vascular hypertrophy secondary to hypertension. 38 Because of the advantages that adventitial gene transfer avoids interruption of blood flow and disruption of the endothelium, as a target for site-specific vascular wall therapy, adventitial-specific gene transfer through the delivery of adenoviral vectors into the peri-arterial sheath has been demonstrated in different animal models.…”

Section: Pai-1 Prevents Aaa Hs Qian Et Almentioning

confidence: 99%

Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice

Hs¹,

Jm²,

P³

et al. 2007

Gene Ther

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Vessel wall inflammation and matrix destruction are critical to abdominal aortic aneurysm (AAA) formation and rupture. We have previously shown that urokinase plasminogen activator (uPA) is highly expressed in experimental AAA and is essential for AAA formation and expansion. In this study, we examined the effects of overexpression of a natural inhibitor of uPA, plasminogen activator inhibitor-1 (PAI-1), on the development of angiotensin (Ang) II-induced AAA in ApoE-deficient (ApoE À/À ) mice. Mice were treated with recombinant adenovirus containing either the human PAI-1 gene (Ad5.CMV.PAI-1) or the luciferase gene (Ad5.CMV.Luc) delivered either locally by intra-adventitial injection or systemically by tail vein injection. Our results show that local delivery of the PAI-1 gene completely prevented AAA formation (0 vs 55.6% in Ad5.CMV.Luc controls, Po0.05). In contrast, systemic delivery of the PAI-1 gene did not affect AAA incidence (78 vs 90% in Ad5.CMV.Luc controls, P ¼ 0.125). Local delivery of the PAI-1 gene 2 weeks after Ang II infusion prevented further expansion of small aneurysms, but had no significant effect on the progression of larger aneurysms. These data suggest that local PAI-1 gene transfer could be used to stabilize small AAA and reduce the rate of expansion and risk of rupture.

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Adventitial Remodeling After Coronary Arterial Injury

Cited by 314 publications

References 32 publications

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

The Relationship between Vascular Function and the Autonomic Nervous System

Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice

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