Advantages of optical fibers for facile and enhanced detection in droplet microfluidics

Hengoju, Sundar; Shvydkiv, Oksana; Tovar, Miguel; Roth, Martin

doi:10.1016/j.bios.2021.113910

Cited by 33 publications

(20 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The acoustic radiation force (ARF) generated by surface acoustic waves can accurately manipulate and capture particles or cells suspended in liquid, which has great application potential [ 8 ]. However, sample detection requires only one drop or less in most testing cases [ 9 ], and also the addition of microchannels, catheters and injection pumps can make the detection system complex and difficult to carry, the difficulty of operation and detection time will also increase at the same time [ 10 ]. Another simpler and more ingenious miniaturization system consists of a piezoelectric substrate and a fixed droplet placed directly on a piezoelectric platform [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Detection in Droplet Microfluidics by Acoustic Vortex Modulation of Particle Rings and Particle Clusters via Asymmetric Propagation of Surface Acoustic Waves

Liu

et al. 2022

Biosensors

View full text Add to dashboard Cite

As a basis for biometric and chemical analysis, issues of how to dilute or concentrate substances such as particles or cells to specific concentrations have long been of interest to researchers. In this study, travelling surface acoustic wave (TSAW)-based devices with three frequencies (99.1, 48.8, 20.4 MHz) have been used to capture the suspended Polystyrene (PS) microspheres of various sizes (5, 20, 40 μm) in sessile droplets, which are controlled by acoustic field-induced fluid vortex (acoustic vortex) and aggregate into clusters or rings with particles. These phenomena can be explained by the interaction of three forces, which are drag force caused by ASF, ARF caused by Leaky-SAW and varying centrifugal force. Eventually, a novel approach of free transition between the particle ring and cluster was approached via modulating the acoustic amplitude of TSAW. By this method, multilayer particles agglomerate with 20 μm wrapped around 40 μm and 20 μm wrapped around 5 μm can be obtained, which provides the possibility to dilute or concentrate the particles to a specific concentration.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhanced Detection in Droplet Microfluidics by Acoustic Vortex Modulation of Particle Rings and Particle Clusters via Asymmetric Propagation of Surface Acoustic Waves

Liu

et al. 2022

Biosensors

View full text Add to dashboard Cite

show abstract

“…The label-free SERS detection is suitable for those targets with strong Raman signals. For labeled SERS-based droplet detection, immuno-modification is used to analyze certain targets [ 121 ]. Figure 3 b shows schematic Raman scattering and SERS-based droplet detection.…”

Section: Detection Methodsmentioning

confidence: 99%

Droplet Detection and Sorting System in Microfluidics: A Review

Huang

Jiang

et al. 2022

Micromachines

View full text Add to dashboard Cite

Since being invented, droplet microfluidic technologies have been proven to be perfect tools for high-throughput chemical and biological functional screening applications, and they have been heavily studied and improved through the past two decades. Each droplet can be used as one single bioreactor to compartmentalize a big material or biological population, so millions of droplets can be individually screened based on demand, while the sorting function could extract the droplets of interest to a separate pool from the main droplet library. In this paper, we reviewed droplet detection and active sorting methods that are currently still being widely used for high-through screening applications in microfluidic systems, including the latest updates regarding each technology. We analyze and summarize the merits and drawbacks of each presented technology and conclude, with our perspectives, on future direction of development.

show abstract

“…Third, in most cases, although the sensor chip is miniaturized owing to advanced nanofabrication technologies, sophisticated instruments (such as the outer light source and optical detector) and precise optical alignments are still required [ 72 ]. While the application of microfluidic systems can simplify sensing operations, additional fluidic control devices such as pump and channels are still complexing the platform.…”

Section: Optical Biosensors For Multi-virus Detectionmentioning

confidence: 99%