Advances in the Application of Injectable Thermosensitive Hydrogel Systems for Cancer Therapy

Xue, Bingxin; Qu, Ying; Shi, Kun; Zhou, Kai; He, Xinlong; Chu, Bingyang; Qian, Zhiyong

doi:10.1166/jbn.2020.2988

Cited by 15 publications

(8 citation statements)

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“…“Smart” thermosensitive hydrogels are materials displaying a sol-gel phase transition in response to temperature, which are superior for NS loading. 23 , 24 Thermosensitive hydrogels maintain good liquidity and low viscosity at lower temperatures and transform into an immobile gel state immediately at body temperature. The easy injection and sustained drug release make thermosensitive hydrogels potentially useful for local drug loading and delivery.…”

Section: Introductionmentioning

confidence: 99%

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization

Zou¹,

He²,

Wang³

et al. 2021

IJN

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Purpose Pore-forming toxins (PFTs) perform important functions during bacterial infections. Among various virulence-targeting therapies, nanosponges (NSs) have excellent neutralization effects on multiple PFTs. To enhance treatment efficacy, NSs tend to be incorporated into other biomaterials, such as hydrogels. Methods In the present work, red blood cell (RBC) vesicles were harvested to wrap polymer nanoparticles, leading to the formation of NSs, and the optimal Pluronic F127 hydrogel concentration was determined for gelation. Then, a novel detoxification system was constructed by incorporating NSs into an optimized Pluronic F127 hydrogel (NS-pGel). Next, the system was characterized by rheological and sustained release behavior as well as micromorphology. Then, the in vitro neutralization effect of NS-pGel on various PFTs was examined by a hemolysis protocol. Finally, therapeutic and prophylactic detoxification efficiency was evaluated in a mouse subcutaneous infection model in vivo. Results A thermosensitive, injectable detoxification system was successfully constructed by loading NSs into a 30% Pluronic F127 hydrogel. Characterization results demonstrated that the NS-pGel hybrid system sustained an ideal fluidity and viscosity at lower temperatures but exhibited a quick sol-gel transition capacity near body temperature. In addition, this hybrid system had a sustained release behavior accompanied by good biocompatibility and biodegradability. Finally, the NS-pGel system showed neutralization effects similar to those of NSs both in vitro and in vivo, indicating a good preservation of NS functionality. Conclusion In conclusion, we constructed a novel temperature-sensitive detoxification system with good biocompatibility and biodegradability, which may be applied to the clinical treatment of PFT-induced local lesions and infections.

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Section: Introductionmentioning

confidence: 99%

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization

Zou¹,

He²,

Wang³

et al. 2021

IJN

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“…Temperature-responsive hydrogels, which are capable of responding to temperature changes, have been extensively studied among the smart hydrogels [ 31 , 32 ]. As the temperature rises above or drops below a certain point, sol–gel phase transition of the thermoresponsive polymer solution occurs immediately and swelling or shrinking of the volume of the matrix happens simultaneously [ 10 , 33 ].…”

Section: Classification Of Smart In Situ Hydrogelsmentioning

confidence: 99%

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

et al. 2022

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Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients’ needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed.

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“…When they enter the body, their efficacy is not fully exerted. Furthermore, due to surface activity, selective exclusion, steric restriction of protein–protein interactions, or through increasing viscosity and reducing protein structural mobility, hydrogels can stabilize proteins and peptides [ 46 , 47 ]. With the help of temperature-sensitive hydrogel delivery systems, the bioavailability of the proteins can be significantly increased, thus making up for the limitations of traditional oral cancer treatment.…”

Section: The Common Types Of Smart Hydrogelsmentioning

confidence: 99%

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Zhao

Ran

Xie

et al. 2022

Gels

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At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow suppression, malfunction of the liver and kidneys, and neurotoxicity. As a new local drug delivery system, the smart drug delivery system based on hydrogel can control drug release in time and space, and effectively alleviate or avoid these problems. Environmentally responsive hydrogels for smart drug delivery could be triggered by temperature, photoelectricity, enzyme, and pH. An overview of the most recent research on smart hydrogels and their controlled-release drug delivery systems for the treatment of oral cancer is given in this review. It is anticipated that the local drug release method and environment-responsive benefits of smart hydrogels will offer a novel technique for the low-toxicity and highly effective treatment of oral malignancy.

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Advances in the Application of Injectable Thermosensitive Hydrogel Systems for Cancer Therapy

Cited by 15 publications

References 0 publications

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization

Injectable Nanosponge-Loaded Pluronic F127 Hydrogel for Pore-Forming Toxin Neutralization

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

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