Advances in Stroke

Meschia, James F.; Tournier‐Lasserve, Elisabeth

doi:10.1161/strokeaha.111.000480

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Generally, the associations between neighborhood availability of the studied resources and CVD were somewhat stronger for stroke than for CHD. Previous research indicates that genetic influence on stroke risk is weaker than for other cardiovascular manifestations [ 42 , 43 ], suggesting that lifestyle and other modifiable risk factors may have stronger influence on the disease development. However, when studying stroke mortality separately we found no associations in women.…”

Section: Discussionmentioning

confidence: 99%

Impact of neighborhood resources on cardiovascular disease: a nationwide six-year follow-up

Calling

Kawakami

et al. 2016

BMC Public Health

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BackgroundLiving in a socially deprived neighborhood is associated with lifestyle risk factors, e.g., smoking, physical inactivity and unhealthy diet, as well as an increased risk of cardiovascular disease, i.e., coronary heart disease and stroke. The aim was to study whether the odds of cardiovascular disease vary with the neighbourhood availability of potentially health-damaging and health-promoting resources.MethodsA nationwide sample of 2 040 826 men and 2 153 426 women aged 35–80 years were followed for six years for first hospitalization of coronary heart disease or stroke. Neighborhood availability of health-damaging resources (i.e., fast-food restaurants and bars/pubs) and health-promoting resources (i.e., health care facilities and physical activity facilities) were determined by use of geographic information systems (GIS).ResultsWe found small or modestly increased odds ratios (ORs) for both coronary heart disease and stroke, related to the availability of both health-damaging and health-promoting resources. For example, in women, the unadjusted OR (95 % confidence interval) for stroke in relation to availability of fast-food restaurants was 1.18 (1.15–1.21). Similar patterns were observed in men, with an OR = 1.08 (1.05–1.10). However, the associations became weaker or disappeared after adjustment for neighborhood-level deprivation and individual-level age and income.ConclusionsThis six year follow-up study shows that neighborhood availability of potentially health-damaging as well as health-promoting resources may make a small contribution to the risk of coronary heart disease and stroke. However, most of these associations were attenuated or disappeared after adjustment for neighborhood-level deprivation and individual-level age and income. Future studies are needed to further examine factors in the causal pathway between neighborhood deprivation and cardiovascular disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-3293-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Impact of neighborhood resources on cardiovascular disease: a nationwide six-year follow-up

Calling

Kawakami

et al. 2016

BMC Public Health

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“…For instance, paired-like homeodomain transcription factor 2 (PITX2) and zinc finger homeobox 3 (ZFHX3) have an association with cardioembolic stroke and histone deacetylase 9 (HDAC9), 9p21 locus and 6p21.1 locus have an association with large artery stroke. 5 However, the odds ratios (OR) associated with these risk alleles are relatively low and account for only a small proportion of estimated heritability.…”

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confidence: 99%

Genetic Variant RNF213 c.14576G>A in Various Phenotypes of Intracranial Major Artery Stenosis/Occlusion

Miyawaki

Imai

Shimizu

et al. 2013

Stroke

141

108

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Background and Purpose-Recently, we reported a common genetic variant, ring finger protein 213 (RNF213) c.14576G>Avariant, a susceptibility gene for moyamoya disease (MMD), among patients with intracranial major artery stenosis/ occlusion (ICASO) in a selected Japanese population. The aim of this 2-center-based case-control study was to confirm our previous finding in a larger population. S.).The online-only Data Supplement is available with this article at http://stroke.ahajournals.org/lookup/suppl

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