Advances in polysaccharides for probiotic delivery: Properties, methods, and applications

Lin, Qianqian; Si, Yanxue; Zhou, Fengshan; Hao, Wenshuai; Zhang, Pai; Jiang, Peng; Cha, Ruitao

doi:10.1016/j.carbpol.2023.121414

Cited by 8 publications

(2 citation statements)

References 263 publications

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“…One promising solution is using polysaccharides, which are non-toxic, highly compatible with biological systems and biodegradable. These polysaccharides can form a protective layer around the probiotics, providing a physical barrier and aiding in their delivery, thereby making them a potential solution for probiotic delivery [ 67 ]. During the growth of Lactobacillus rhamnosus ATCC 53103 probiotic bacteria, freeze-dried polysaccharides extracted from U. rigida were replaced as a substrate in the culture medium.…”

Section: Discussionmentioning

confidence: 99%

Extraction, Characterisation and Evaluation of Antioxidant and Probiotic Growth Potential of Water-Soluble Polysaccharides from Ulva rigida Macroalgae

Phomkaivon,

Pongponpai,

Kosawatpat

et al. 2024

Foods

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Ulva rigida green macroalgae contain a variety of polysaccharides. A recent study investigated the optimum concentration and yield of polysaccharide extraction from oven-dried U. rigida biomass using a water-soluble polysaccharide extraction method that adhered to safety standards. This study utilised complete factorial experiments to examine the effects of varying factors on polysaccharide extraction. Results showed a positive correlation between increased levels of all factors and higher polysaccharide extraction yield. This study also found that the main factors and their interaction had a significant impact on the extracted polysaccharides from U. rigida. The highest polysaccharide content and yield were 9.5 mg/mL and 189 mg/g, respectively. Water-soluble polysaccharides demonstrated the presence of reducing sugar (8 mg/g), phenolics (0.69 mg/g) and flavonoids (1.42 mg/g) and exhibited antioxidant properties. Results revealed that freeze-dried polysaccharide powders were primarily composed of the monosaccharide rhamnose. Preliminary results on the effect of these powders on probiotics demonstrated that supplementation of polysaccharides from U. rigida promoted viable Lactobacillus rhamnosus ATCC 53103 growth during cultivation. This discovery has the potential to revolutionise the human food industry and promote the development of functional ingredients for novel and future food products, with numerous applications in the nutraceutical and pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

Extraction, Characterisation and Evaluation of Antioxidant and Probiotic Growth Potential of Water-Soluble Polysaccharides from Ulva rigida Macroalgae

Phomkaivon,

Pongponpai,

Kosawatpat

et al. 2024

Foods

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“…Qizilbash et al highlighted the role of lipid-based nanocarriers in the treatment of breast cancer [ 52 ]. Standard breast cancer treatments encompass surgery, chemotherapy, and radiotherapy.…”

Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Recent trends in nanocellulose: Metabolism-related, gastrointestinal effects, and applications in probiotic delivery

Liu,

Wu,

Dong

et al. 2024

Carbohydrate Polymers

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Advances in polysaccharides for probiotic delivery: Properties, methods, and applications

Cited by 8 publications

References 263 publications

Extraction, Characterisation and Evaluation of Antioxidant and Probiotic Growth Potential of Water-Soluble Polysaccharides from Ulva rigida Macroalgae

Extraction, Characterisation and Evaluation of Antioxidant and Probiotic Growth Potential of Water-Soluble Polysaccharides from Ulva rigida Macroalgae

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Recent trends in nanocellulose: Metabolism-related, gastrointestinal effects, and applications in probiotic delivery

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