Advances in dissecting mosquito innate immune responses to arbovirus infection

Atkinson, Barry; Attarzadeh-Yazdi, Ghassem; Nash, Anthony; Fazakerley, John K.; Kohl, Alain

doi:10.1099/vir.0.013201-0

Cited by 108 publications

(114 citation statements)

References 127 publications

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“…33 Such interactions may be mediated by mosquito immunity; however, more research in this area is needed. 34 Alternatively, the negative associations may reflect associations between the ecological conditions that favor each virus.…”

Section: Discussionmentioning

confidence: 99%

Impact of Climate and Mosquito Vector Abundance on Sylvatic Arbovirus Circulation Dynamics in Senegal

Althouse

Hanley

Diallo

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Sylvatic arboviruses have been isolated in Senegal over the last 50 years. The ecological drivers of the pattern and frequency of virus infection in these species are largely unknown. We used time series analysis and Bayesian hierarchical count modeling on a long-term arbovirus dataset to test associations between mosquito abundance, weather variables, and the frequency of isolation of dengue, yellow fever, chikungunya, and Zika viruses. We found little correlation between mosquito abundance and viral isolations. Rainfall was a negative predictor of dengue virus (DENV) isolation but a positive predictor of Zika virus isolation. Temperature was a positive predictor of yellow fever virus (YFV) isolations but a negative predictor of DENV isolations. We found slight interference between viruses, with DENV negatively associated with concurrent YFV isolation and YFV negatively associated with concurrent isolation of chikungunya virus. These findings begin to characterize some of the ecological associations of sylvatic arboviruses with each other and climate and mosquito abundance.

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Section: Discussionmentioning

confidence: 99%

Impact of Climate and Mosquito Vector Abundance on Sylvatic Arbovirus Circulation Dynamics in Senegal

Althouse

Hanley

Diallo

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…The RNAi response is essential for controlling virus replication and limiting virusinduced pathology in insects (2,6), and inherently provides response specificity. Signaling pathways such as the Toll, Imd, and Jak-STAT pathways have also been implicated in the insect antiviral response (8)(9)(10)(11). These signaling pathways lead to the activation of transcription factors and the subsequent expression of antimicrobial peptides.…”

mentioning

confidence: 99%

Making connections in insect innate immunity

Kingsolver

Hardy

2012

Proc. Natl. Acad. Sci. U.S.A.

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“…The exogenous siRNA pathway is considered to be the most important antiviral mechanism in arbovirus vectors such as mosquitoes [14]. The mechanism in mosquitoes is very similar to the one described for the model organism D. melanogaster (reviewed by [32,34]). Upon infection, RNA viruses introduce or generate foreign dsRNA in the arthropod cell either as replication intermediates, or as part of their dsRNA genome or as secondary structures of their ssRNA genome.…”

Section: Mirnasmentioning

confidence: 98%

“…All of the three major innate immunity signalling pathways in insects, namely Janus kinase/signal transducer and activator of transcription (JAK/STAT), Toll and Immune deficiency (Imd), have been implicated in antiviral defences in insects (reviewed by [34,62,81] ). All three pathways also play a role in development and especially in immune responses to other pathogens.…”

Section: Antiviral Responses Triggered By Innate Immunity Signalling mentioning

confidence: 99%

“…In the 2005-2006 outbreak of chikungunya fever on the Indian Ocean island of La Reunion, rapid replication and dissemination of this infection was associated with a single point mutation in the viral envelope glycoprotein which adapted the virus to replicate in and to be disseminated by anthropophilic Aedes albopictus mosquitoes [121]. All arboviruses have to deal with at least two very different immune systems and, while research into and knowledge of arbovirus-host interaction in vertebrate systems is well developed, knowledge of vector antiviral responses has been gained principally over the last 10 years [32,34,62,81]. This review aims to summarise knowledge to date about antiviral responses of arthropod vectors to arboviruses.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral responses of arthropod vectors: an update on recent advances

et al. 2014

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Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many viruses that can cause outbreaks of disease in humans and animals around the world. Arthropod vector species are invading new areas due to globalisation and environmental changes, and contact between exotic animal species, humans and arthropod vectors is increasing, bringing with it the regular emergence of new arboviruses. For future strategies to control arbovirus transmission, it is important to improve our understanding of virus-vector interactions. In the last decade knowledge of arthropod antiviral immunity has increased rapidly. RNAi has been proposed as the most important antiviral response in mosquitoes and it is likely to be the most important antiviral response in all arthropods. However, other newly-discovered antiviral strategies such as melanisation and the link between RNAi and the JAK/STAT pathway via the cytokine Vago have been characterised in the last few years. This review aims to summarise the most important and most recent advances made in arthropod antiviral immunity.

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Advances in dissecting mosquito innate immune responses to arbovirus infection

Cited by 108 publications

References 127 publications

Impact of Climate and Mosquito Vector Abundance on Sylvatic Arbovirus Circulation Dynamics in Senegal

Impact of Climate and Mosquito Vector Abundance on Sylvatic Arbovirus Circulation Dynamics in Senegal

Making connections in insect innate immunity

Antiviral responses of arthropod vectors: an update on recent advances

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