Advances in circadian clock regulation of reproduction

Li, Yating; Zhang, Haisen; Wang, Yudong; Li, Dan; Chen, Huatao

doi:10.1016/bs.apcsb.2023.02.008

Cited by 2 publications

(2 citation statements)

References 250 publications

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“…The timing of ovulation in poultry is controlled by the hypothalamic-pituitary-gonadal axis, which is also affected by the circadian rhythm system. The ovarian circadian clock has been documented in many species and its function is related to the timing of gene expression in mature granulosa cells ( Sen and Hoffmann, 2020 ; Li et al, 2023 ). Geese are characterized by a 48-h period of ovulation-oviposition cycle.…”

Section: Discussionmentioning

confidence: 99%

Circadian clock gene BMAL1 regulates STAR expression in goose ovarian preovulatory granulosa cells

Chen,

Qin,

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Circadian clock gene BMAL1 regulates STAR expression in goose ovarian preovulatory granulosa cells

Chen,

Qin,

et al. 2023

Poultry Science

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“…Certainly, the duration of daylight and onset of light or dark ( Hastings et al, 1985 ; Wright et al, 2013 ) influences the release of GnRH and gonadotropins. The suprachiasmatic nucleus (SCN) conveys time-of-the-day signals to the HPG ( Wiegand et al, 1980 ; Li et al, 2023 ). Human studies have shown that central pubertal activation is accompanied by a nocturnal rise in luteinizing hormones (LH) concentrations, in both males and females ( Demir et al, 2023 ) and that disruption of daily cycles (e.g., chronic shift work) impacts both male and female reproduction and fertility ( Moralia et al, 2022 for review), pinpointing the importance of understanding how the SCN message is integrated by the HPG axis.…”

Section: Introductionmentioning

confidence: 99%

Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current

Constantin,

Quignon,

Pizano

et al. 2024

Front. Cell. Neurosci.

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Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic nucleus (SCN) which relays circadian information to neuronal populations, including GnRH neurons. Human and animal studies have shown an impact of disrupted daily rhythms (chronic shift work, temporal food restriction, clock gene disruption) on both male and female reproduction and fertility. To date, how VIP modulates GnRH neurons remains unknown. Calcium imaging and electrophysiology on primary GnRH neurons in explants and adult mouse brain slice, respectively, were used to address this question. We found VIP excites GnRH neurons via the VIP receptor, VPAC2. The downstream signaling pathway uses both Gs protein/adenylyl cyclase/protein kinase A (PKA) and phospholipase C/phosphatidylinositol 4,5-bisphosphate (PIP2) depletion. Furthermore, we identified a UCL2077-sensitive target, likely contributing to the slow afterhyperpolarization current (IAHP), as the PKA and PIP2 depletion target, and the KCa3.1 channel as a specific target. Thus, VIP/VPAC2 provides an example of Gs protein-coupled receptor-triggered excitation in GnRH neurons, modulating GnRH neurons likely via the slow IAHP. The possible identification of KCa3.1 in the GnRH neuron slow IAHP may provide a new therapeutical target for fertility treatments.

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Advances in circadian clock regulation of reproduction

Cited by 2 publications

References 250 publications

Circadian clock gene BMAL1 regulates STAR expression in goose ovarian preovulatory granulosa cells

Circadian clock gene BMAL1 regulates STAR expression in goose ovarian preovulatory granulosa cells

Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current

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