Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration

Composite Bioinks With Mesoporous Bioactive Glasses—A Critical Evaluation of Results Obtained by In Vitro Experiments

“…Besides the effect of the BG and MBG on physicochemical properties of composite hydrogel based-inks, its addition to bioinks also affects the embedded cells. These effects have been reported with BG (Heid and Boccaccini, 2020;Zeimaran et al, 2021). Besides very recent studies (Guduric et al, 2021;Tavares et al, 2021), there is lack of data in literature about bioprinted cells within the MBG-hydrogel composites.…”

“…Alginate-based hydrogels can be easily combined with particulate materials, such as bioactive glasses, making them processable with 3D printing technologies. Bioactive glasses (BGs) have been combined with hydrogels affecting gelation, rheological, mechanical and degradation properties of final composites, depending on their initial composition and concentration ( Zeimaran et al, 2021 ). Furthermore, the addition of BG affects shape fidelity, which represents the difference of the printed constructs to the related designed 3D model.…”

Bioprinting and regeneration of auricular cartilage using a bioactive bioink based on microporous photocrosslinkable acellular cartilage matrix

“…Recently, natural hydrogels (such as gelatin, collagen, alginate, hyaluronic acid, etc. ), which can effectively alleviate the aseptic inflammatory reaction problem, have become the research hotspot of tissue engineering scaffolds [ [15] , [16] , [17] ]. Three-dimensional (3D) bioprinting technology, which enables precisely defining the spatial distribution of cells and materials, has significant application advantages in the biomimetic construction of tissues and organs [ [18] , [19] , [20] , [21] , [22] ].…”

Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing

“…In the field of skin tissue engineering, composite hydrogels are able to prepare tunable bioinks to match the features of native skin [ 11 ]. Because of the high surface property of nanomaterials, the performances of hydrogel could be influenced by a low concentration of nanoparticles [ 70 ]. Nanomaterials are being used to introduce new functions to bioinks such as mechanical reinforcement, printability improvement and cell behavior regulation [ 71 ].…”