Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow

Osch, Matthias J.P. van; Teeuwisse, Wouter M.; Chen, Zhensen; Suzuki, Yukiko; Helle, Michael; Schmid, Sophie

doi:10.1177/0271678x17713434

Cited by 86 publications

(80 citation statements)

References 107 publications

(155 reference statements)

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“…Although segmented 3D sequences (e.g., 3D GRASE and 3D stack of spirals) are preferable readout modules for traditional ASL scans, because of optimal background suppression over the whole imaging volume (5), te-pCASL results in an increased temporal footprint, making segmented 3D readout acquisitions more prone to motion artifacts (20), while single-shot 3D readout approaches suffer from blurring. Therefore, single-shot multislice EPI sequences were used in this study, even though development of improved 3D sequences that allow single-shot readout (or with a low number of segments), while avoiding blurring, could bring further improvements to our approach.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous acquisition of perfusion image and dynamic MR angiography using time‐encoded pseudo‐continuous ASL

Suzuki

Helle

Koken

et al. 2017

Magnetic Resonance in Med

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PurposeBoth dynamic magnetic resonance angiography (4D‐MRA) and perfusion imaging can be acquired by using arterial spin labeling (ASL). While 4D‐MRA highlights large vessel pathology, such as stenosis or collateral blood flow patterns, perfusion imaging provides information on the microvascular status. Therefore, a complete picture of the cerebral hemodynamic condition could be obtained by combining the two techniques. Here, we propose a novel technique for simultaneous acquisition of 4D‐MRA and perfusion imaging using time‐encoded pseudo‐continuous arterial spin labeling.MethodsThe time‐encoded pseudo‐continuous arterial spin labeling module consisted of a first subbolus that was optimized for perfusion imaging by using a labeling duration of 1800 ms, whereas the other six subboli of 130 ms were used for encoding the passage of the labeled spins through the arterial system for 4D‐MRA acquisition. After the entire labeling module, a multishot 3D turbo‐field echo‐planar‐imaging readout was executed for the 4D‐MRA acquisition, immediately followed by a single‐shot, multislice echo‐planar‐imaging readout for perfusion imaging. The optimal excitation flip angle for the 3D turbo‐field echo‐planar‐imaging readout was investigated by evaluating the image quality of the 4D‐MRA and perfusion images as well as the accuracy of the estimated cerebral blood flow values.ResultsWhen using 36 excitation radiofrequency pulses with flip angles of 5 or 7.5°, the saturation effects of the 3D turbo‐field echo‐planar‐imaging readout on the perfusion images were relatively moderate and after correction, there were no statistically significant differences between the obtained cerebral blood flow values and those from traditional time‐encoded pseudo‐continuous arterial spin labeling.ConclusionsThis study demonstrated that simultaneous acquisition of 4D‐MRA and perfusion images can be achieved by using time‐encoded pseudo‐continuous arterial spin labeling. Magn Reson Med 79:2676–2684, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Discussionmentioning

confidence: 99%

Simultaneous acquisition of perfusion image and dynamic MR angiography using time‐encoded pseudo‐continuous ASL

Suzuki

Helle

Koken

et al. 2017

Magnetic Resonance in Med

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“…ASL utilizes the label arterial blood water proton capability as internal contrast-enhanced tracer. CBF was the important parameter arisen from this sequence [12,13]. There are some different kinds…”

Section: Group B Aslmentioning

confidence: 95%

“…ASL can be indicated in assessment of cerebrovascular stroke, vascular malformation, encephalitis, migraineassociated, hyperperfusion, hypoperfusion, dementia, migraine, infectious etiologies, physiologic quantification, posterior reversible encephalopathy syndrome, cognitive disorders, pediatric patients, immunocompromised patients, patients with GBCE allergy and impaired renal function patients [12,13].…”

Section: Short Communicationmentioning

confidence: 99%

Clinical approach of perfusion-weighted imaging

Duc¹,

Huy²,

Bang³

et al. 2018

Imaging-Medicine

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Perfusion is one of the most important parameters affected on the diagnosis, treatment planning, and disease response to therapy. There are some discriminative kinds of perfusion-weighted imaging (PWI) such as dynamic susceptibility contrast PWI, semiquantitative dynamic contrast-enhanced PWI, quantitative dynamic contrast-enhanced PWI, dynamic glucose-enhanced PWI, arterial spin labelling and amide proton transfer. In this short communication, we aimed to introduce clinical approach of these PWI types.

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“…More detailed description about the principles of ASL can be found in several excellent review articles. [18][19][20][21]…”

Section: Introductionmentioning

confidence: 99%

Intracranial 3D and 4D MR Angiography Using Arterial Spin Labeling: Technical Considerations

Suzuki

Fujima

Osch

2020

MRMS

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In the 1980's some of the earliest studies of arterial spin labeling (ASL) MRI have demonstrated its ability to generate MR angiography (MRA) images. Thanks to many technical improvements, ASL has been successfully moving its position from the realm of research into the clinical area, albeit more known as perfusion imaging than as MRA. For MRA imaging, other techniques such as time-of-flight, phase contrast MRA and contrast-enhanced (CE) MRA are more popular choices for clinical applications. In the last decade, however, ASL-MRA has been experiencing a remarkable revival, especially because of its non-invasive nature, i.e. the fact that it does not rely on the use of contrast agent. Very importantly, there are additional benefits of using ASL for MRA. For example, its higher flexibility to achieve both high spatial and temporal resolution than CE dynamic MRA, and the capability of vessel specific visualization, in which the vascular tree arising from a selected artery can be exclusively visualized. In this article, the implementation and recent developments of ASL-based MRA are discussed; not only focusing on the basic sequences based upon pulsed ASL or pseudo-continuous ASL, but also including more recent labeling approaches, such as vessel-selective labeling, velocity-selective ASL, vessel-encoded ASL and time-encoded ASL. Although these ASL techniques have been already utilized in perfusion imaging and their usefulness has been suggested by many studies, some additional considerations should be made when employing them for MRA, since there is something more than the difference of the spatial resolution of the readout sequence. Moreover, extensive discussion is included on what readout sequence to use, especially by highlighting how to achieve high spatial resolution while keeping scan-time reasonable such that the ASL-MRA sequence can easily be included into a clinical examination.

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Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow

Cited by 86 publications

References 107 publications

Simultaneous acquisition of perfusion image and dynamic MR angiography using time‐encoded pseudo‐continuous ASL

Simultaneous acquisition of perfusion image and dynamic MR angiography using time‐encoded pseudo‐continuous ASL

Clinical approach of perfusion-weighted imaging

Intracranial 3D and 4D MR Angiography Using Arterial Spin Labeling: Technical Considerations

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