Advancements in prophylactic and therapeutic nanovaccines

Bhardwaj, Prateek; Bhatia, Eshant; Sharma, Shivam; Ahamad, Nadim; Banerjee, Rinti

doi:10.1016/j.actbio.2020.03.020

Cited by 106 publications

(79 citation statements)

References 209 publications

(165 reference statements)

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“…Activation of CTLs depends on signals generation by dendritic cells, T helper cells, and other cells. Finally, T-helper lymphocyte cells activate CTLs releasing cytotoxic granules against viral invading [ 54 ] .…”

Section: Virosomesmentioning

confidence: 99%

Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Asadi

Gholami

2021

International Journal of Biological Macromolecules

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Vaccination is the most effective means of controlling infectious disease-related morbidity and mortality. However, due to low immunogenicity of viral antigens, nanomedicine as a new opportunity in new generation of vaccine advancement attracted researcher encouragement. Virosome is a lipidic nanomaterial emerging as FDA approved nanocarriers with promising bioinspiration and biomimetic potency against viral infections. Virosome surface modification with critical viral fusion proteins is the cornerstone of vaccine development. Surface antigens at virosomes innovatively interact with targeted receptors on host cells that evoke humoral or cellular immune responses through antibody-producing B cell and internalization by endocytosis-mediated pathways. To date, several nanovaccine based on virosome formulations have been commercialized against widespread and life-threatening infections. Recently, Great efforts were made to fabricate a virosome-based vaccine platform against a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Thus, this review provides a novel overview of the virosome based nanovaccine production, properties, and application on the viral disease, especially its importance in SARS-CoV-2 vaccine discovery.

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Section: Virosomesmentioning

confidence: 99%

Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Asadi

Gholami

2021

International Journal of Biological Macromolecules

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“…It is imperative to look up and further rationalize the potential aspects of nanomaterials, for instance the facile synthesis, requirement of lower doses yet alleviation of repetitive booster injections, easy routes of administration, etc. of nano-vaccines over conventional vaccines [ 48 , 49 ].…”

Section: Challenges and Future Prospects In Nano-vaccinesmentioning

confidence: 99%

Topical review on nano-vaccinology: Biochemical promises and key challenges

Zaheer

Pal

Zaheer

2021

Process Biochemistry

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“…Antigen processing cells have ability of capturing microparticulate Ag complex to boost adaptive autoimmune responses that subsist with pathogen after entering inside an organism. Nanomaterials have inbuilt immunomodulatory properties that can impact therapeutic action of vaccine [ 100 ]. Hence, these can be a good choice to evade viral diseases.…”

Section: Nano Vaccine Models Of Relevance In the Fight Against Covid-mentioning

confidence: 99%

Recent Advancement in SARS-CoV-2 Diagnosis, Treatment, and Vaccine Formulation: a New Paradigm of Nanotechnology in Strategic Combating of COVID-19 Pandemic

et al. 2021

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Purpose of Review The coronavirus disease-2019 (COVID-19) is a global pandemic which has not been seen in recent history, leaving behind deep socioeconomic damages and huge human losses with the disturbance in the healthcare sector. Despite the tremendous international effort and the launch of various clinical trials for the containment of this pandemic, no effective therapy has been proven yet. Recent Findings This review has highlighted the different traditional therapeutic techniques, along with the potential contribution of nanomedicine against the severe acute respiratory syndrome corovirus-2 (SARS-CoV-2). Repositioning of the drugs, such as remdesivir and chloroquine, is a rapid process for the reach of safe therapeutics, and the related clinical trials have determined effects against COVID-19. Various protein-based SARS-CoV-2 vaccine candidates have successfully entered clinical phases, determining positive results. The self-assembled and metallic nanovaccines mostly based on the antigenic properties of spike (S) protein are also approachable, feasible, and promising techniques for lowering the viral burden. Summary There are number of NP-based diagnostic systems have been reported for coronaviruses (CoVs) and specifically for SARS-CoV-2. However, extensive studies are still necessary and required for the nanoparticle (NP)-based therapy.

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Advancements in prophylactic and therapeutic nanovaccines

Cited by 106 publications

References 209 publications

Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Topical review on nano-vaccinology: Biochemical promises and key challenges

Recent Advancement in SARS-CoV-2 Diagnosis, Treatment, and Vaccine Formulation: a New Paradigm of Nanotechnology in Strategic Combating of COVID-19 Pandemic

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