Advanced Technologies in Dermatology

Abstract

Cellular therapies are an attractive area of regenerative medicine. For large partial thickness wound, keratinocytes transplant is suggested. The transplantation of cell graft is achieved by obtaining large amounts of cultured cells from a skin biopsy in 3 weeks. Stem cells can be applied before that, but are also efficient in chronic wound closure. Alternative treatment methods are transplants of allogeneic, biostatic skin and amnion. Amnion can be applied as a skin substitute on shallow facialburn wounds, hand burn wounds, on donor areas and granulating wounds. For medium depth or even deep burns, allogeneic skin is recommended. Thanks to the removing of cells from human allogeneic dermis, collagen scaffolding is obtained. It can be populated de novo by autologous skin cells. Artificial skin substitutes are especially good for hand burns and shallow burns. Even though scarring is a part of normal wound healing, it often leads to a pathological process. When scar treatment methods prove insufficient, surgical intervention becomes necessary. Surgical scar intervention involves removal of the pathological skin tissue fragment and replacing it with healthy skin or application of expanders. Improvement of the visual features can be also achieved by laser therapy.

Autologous Induced Pluripotent Stem Cell–Based Cell Therapies: Promise, Progress, and Challenges

“…Autologous therapies are considered safer than allogeneic from an immune rejection standpoint (Eliopoulos, Stagg, Lejeune, Pommey, & Galipeau, 2005;Kitala et al, 2016;Sohn et al, 2015;Song et al, 2020). Still, the immunogenicity of autologous iPSCs is not without controversy.…”