Biochemical Pharmacology volume 76, issue 9, P1110-1120 2008 DOI: 10.1016/j.bcp.2008.08.011 View full text
Kanola C. David, Roderick H. Scott, Graeme F. Nixon

Abstract: Advanced glycation endproducts (AGEs) are proteins that accumulate in the plasma of diabetics as a result of increased glucose concentrations and are closely linked with vascular disease. The mechanisms involved are still not clear. The aim of this study was to investigate whether AGE-induced changes in calcium (Ca2+) homeostasis could contribute to these mechanisms. Cultured porcine coronary artery vascular smooth muscle (VSM) cells were preincubated with glycated albumin for 96 h. The sphingosine 1-phosphate…

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