2017
DOI: 10.1016/j.matbio.2016.09.001
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Abstract: Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation End-products (AGEs). Besides being part of the typical aging process, type II diabetics are particularly affected by AGE accumulation due to abnormally high levels of systemic glucose that increases the glycation rate of long-lived proteins such as collagen. Although AGEs are associated with a wide range of clinical disorders, the mechanisms by which AGEs con… Show more

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Cited by 193 publications
(181 citation statements)
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“…2b, c) suggests much higher levels of pentosidine and other fluorescent AGEs than in the young adult tissues. It was found previously that pentosidine was positively related to age in human Achilles tendon [42][43][44] and in meniscus an exponential increase in pentosidine with age was stated [45]. As concerns calorimetric studies, an age-related increase in denaturation temperature in tendon was previously reported [21,46], but there are no other reports on thermal denaturation of meniscus in relation to ageing.…”
Section: Discussionmentioning
confidence: 94%
“…2b, c) suggests much higher levels of pentosidine and other fluorescent AGEs than in the young adult tissues. It was found previously that pentosidine was positively related to age in human Achilles tendon [42][43][44] and in meniscus an exponential increase in pentosidine with age was stated [45]. As concerns calorimetric studies, an age-related increase in denaturation temperature in tendon was previously reported [21,46], but there are no other reports on thermal denaturation of meniscus in relation to ageing.…”
Section: Discussionmentioning
confidence: 94%
“…This tissue barrier represents the first interface of ''handshaking" between the intrinsic and extrinsic tendon compartments. Higher level structural organization of tendon tissue reflects the function of the muscle-tendon unit, with fascicle-fascicle kinematics (sliding and stretching) that dictate the mechanical behavior of the tendon [12,17,[55][56][57][58][59][60]. The fibrillar collagen matrix also includes collagen III in various quantities.…”
Section: Tendon Core -Multiscale Structure and Functionmentioning
confidence: 99%
“…the digital tendons) are low in cross-links [42]. Aging tendons are increasingly crosslinked resulting in altered viscoelastic properties, with potentially increased risk for micro-damage accumulation and onset of tendon disease [56,57,85,101]. Fig.…”
Section: Tendon Core -Multiscale Structure and Functionmentioning
confidence: 99%
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