Advanced diffuse gastric adenocarcinoma in young Syrian woman. A case report

Alhalabi, Marouf; Saddam, A. Alsayd; Mazen, E. Albattah

doi:10.1016/j.amsu.2022.103728

Cited by 2 publications

(6 citation statements)

References 18 publications

(17 reference statements)

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“…From published studies and a few case reports, low back pain is the masquerading presentation for gastric adenocarcinoma and usually, appears in advanced stages due to metastasis and not initial presentation of disease. 7 , 8 , 14 , 15 , 23 In this case, a 30‐year‐old male presented with low back pain and difficulty breathing. During the presentation, there was no family history of cancers especially in first‐degree relatives.…”

Section: Discussionmentioning

confidence: 97%

“…Following a poor response to tuberculosis chemotherapy, additional tests revealed advanced gastric adenocarcinoma. The delay in getting the correct diagnosis underscores the challenges of recognizing unusual presentations of gastric adenocarcinoma, particularly in young patients from infectious disease‐endemic areas 7,14 . This is a learning point for physicians to be vigilant and aware of various clinical circumstances and consider modern imaging, including OGD to reveal concealed neoplastic processes 10,18 .…”

Section: Discussionmentioning

confidence: 99%

“…Diffuse gastric adenocarcinoma in younger age is due to the interplay between genetics and environments and portends poor clinical outcomes with a high mortality rate occurring in less than 12 months. 7 , 13 , 14 , 15 , 16 The clinical symptoms of gastric cancer in symptomatic patients may include vomiting, dyspepsia, dysphagia, early satiety, weight loss, and/or iron deficiency anemia. 17 The instance of gastric adenocarcinoma that is being reported defies standard diagnostic assumptions and highlights the importance of identifying unusual symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…In Tanzania, the prevalence of gastric malignancy is 4.5%, the median age of presentation is 52 years, and gastric adenocarcinoma is the most common histological type 5 . The most common presenting symptoms and signs of gastric adenocarcinoma include abdominal pain, nausea and vomiting, indigestion, unintentional weight loss, anemia, and palpable gastric lump 3,4,6,7 . Occasionally, there are atypical presentations including low back pain and respiratory symptoms indicating an advanced stage of adenocarcinoma especially in the younger demographic without obvious gastrointestinal signs and symptoms 8 .…”

Section: Introductionmentioning

confidence: 99%

“… 5 The most common presenting symptoms and signs of gastric adenocarcinoma include abdominal pain, nausea and vomiting, indigestion, unintentional weight loss, anemia, and palpable gastric lump. 3 , 4 , 6 , 7 Occasionally, there are atypical presentations including low back pain and respiratory symptoms indicating an advanced stage of adenocarcinoma especially in the younger demographic without obvious gastrointestinal signs and symptoms. 8 This highlights a need for clinicians to have heightened suspicion of gastric adenocarcinoma in younger patients from regions with prevalent infectious diseases and broadening differentials.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Diffuse type gastric adenocarcinoma with atypical presentation: A case report

Edwin,

Mbishi,

Zerd

et al. 2024

Clinical Case Reports

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Key Clinical MessageGastric adenocarcinoma can present uncommonly. This emphasizes the need for intensified vigilance in the absence of typical gastrointestinal symptoms, particularly in areas where infectious diseases are common.AbstractGastric adenocarcinoma, a common advanced‐age global malignancy is typically associated with abdominal symptoms. However, atypical presentations such as back pain and respiratory distress particularly in younger patients represent diagnostic challenges. We present a case of a late‐30s male who presented initially with back pain, shortness of breath, and constitutional symptoms. A diagnosis of tuberculosis was established presumptively with immediate initiation of treatment. Later on, he presented with abdominal pain and intractable vomiting. Oesophagoduodenoscopy (OGD), tissue histology, and immunohistochemistry confirmed a diffuse type gastric adenocarcinoma. He died as a result of complications from an advanced disease. This particular instance emphasizes the importance of maintaining a high index of skepticism even in atypical presentations, as well as the significance of prompt OGD alongside potential genetic testing if any. Gastric adenocarcinoma should be contemplated by clinicians in a variety of clinical scenarios, especially when handling younger patients from settings with limited resources to facilitate timely diagnosis and effective treatment.

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