Advanced Collagen‐Based Biomaterials for Regenerative Biomedicine

Abstract

In recent decades, collagen is one of the most versatile biomaterials used in biomedical applications, mostly due to its biomimetic and structural composition in the extracellular matrix (ECM). Several attempts are proposed for designing innovative collagen-based biomaterials and applying them in tissue regeneration. The regeneration of different tissues is prompted by different types and diverse physical forms of collagen-based biomaterials prepared by various methods. Based on such concepts, the source, structure, and classification of collagen are briefly introduced in this review. Here, the commonly used physical forms and modification methods of collagen-based biomaterials are reviewed, including hydrogels, scaffolds, and microspheres, followed by their applications in the regeneration of tissues and organs. Important proof-of-concept examples are described to demonstrate the outcomes on material characteristics, cellular reactions, and tissue regeneration. A concise assessment of the limitations that still exist and the developing trends in the future of collagen-based biomaterials are put forward.

Development of polypyrrole/collagen/nano-strontium substituted bioactive glass composite for boost sciatic nerve rejuvenation in vivo

“…The XRD spectrum of PPY/Coll and PPY/Coll/n-Sr@BG appear in Figure 1(b). As can be seen, the PPY/Coll composite display wide planes at two-theta ¼ 24, which might be because of the undefined idea of collagen particles [19]. Similarly, the PPY/Coll/n-Sr@BG (demonstrates a wide planes at two-theta ¼ 24) [32].…”

Enhanced Removal of p-Arsanilic Acid Using a Collagen Fiber-Derived Mg–Zn–Fe Metal Oxide Monolith

“…In the analysis of FTIR results (Figure a), a large number of hydrogen donors (for example, C–H and −NH 2 groups) and hydrogen acceptors (for example, −OH and −NH 2 groups) were confirmed to present on both the CF-PEI@MZF monolith and p -ASA. , As such, there is a possibility of hydrogen bond formation between them during the adsorption. To verify the hydrogen bonding interaction, we analyzed the change of the element species on the CF-PEI@MZF monolith before and after adsorption by XPS technique.…”

Recombinant human collagen type III microgel: an advanced injectable dermal filler for rejuvenating aging skin

“…However, as observed in Figure 4B , despite its relatively slow degradation, the presence of voids around the injection site of HA was noticeable. pCollagen is primarily composed of cross-linked Col I purified from pig skin, featuring a unique triple helix structure with approximately 3000 amino acids and a molecular weight of around 300 000 g/mol [ 54 , 55 ]. In comparison, rhCol III expressed in Pichia pastoris yeast has a close resemblance of amino acid composition to native human collagen, with a molecular weight of 49 554 g/mol.…”