Adults With Atopic Dermatitis and Herpes Simplex and Topical Therapy With Tacrolimus: What Kind of Prevention?

Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis

“…7,[9][10][11][12][13][14][17][18][19][20] Sporadic reports of HSV and eczema herpeticum during topical tacrolimus therapy have emerged; however, these provide no perspective on the frequency or severity. [21][22][23][24] In contrast, a 6% to 10% incidence of HSV was found in 3 separate reports of patients with AD treated conventionally before the availability of topical tacrolimus: a 7.4% incidence in 502 adult patients with ongoing AD 13 ; a 6% incidence in 179 children (age 5 months-8 years) with severe or intractable atopic eczema observed for a period of 2.75 years 18 ; and a 9.7% incidence in 150 pediatric patients with AD. 12 The overall incidence rates of HSV in the current study were lower compared with these historic control subjects: 4.3% incidence among children 2 to 6 years of age and 6.3% incidence among children 7 to 15 years of age.…”

The Clinical Spectrum and Therapeutic Challenge of Eczema Herpeticum

“…Chronic and recurrent cutaneous herpes cannot be easily distinguished from eczema infected with Staphylococcus aureus or group A Streptococcus. Without an increased index of suspicion, eczema herpeticum may not be recognized, even among subjects followed in clinical trials (4,5). Systemic immunosuppressive therapy could ultimately potentiate skin disease in this subset of atopic patients.…”

A Case Series of Kaposi′s Varicelliform Eruption in Dermatology in-Patients in a Tertiary Care Centre

“…[2] KVE has also been reported in congenital ichthyosiform erythroderma, Wiskott-Aldrich syndrome, seborrheic dermatitis, neurodermatitis, pityriasis rubra pilaris, staphylococcal scalded skin syndrome,[10] scabies,[5] bullous pemphigoid,[5] irritant dermatitis,[11] pemphigus vulgaris,[56] toxic epidermal necrolysis,[6] sunburn, after dermatologic therapeutics including skin autografting, topical tacrolimus for atopic dermatitis, after dermabrasion, after vaccination with BCG and vaccinia, and lupus vulgaris. [4581112] KVE has also been reported in Grover's disease,[13] rosacea,[14] and parthenium dermatitis. [15] In our study, KVE occurred in patients with erythroderma (secondary to ABCD, psoriasis, and CTCL), pemphigus vulgaris, toxic epidermal necrolysis, ABCD, lichenoid drug rash, and DRESS.…”