Adult Stem Cell Therapy for Stroke: Challenges and Progress

Bang, Oh Young; Kim, Eun Hee; Min, Jae; Moon, Gyeong Joon

doi:10.5853/jos.2016.01263

Cited by 93 publications

(98 citation statements)

References 111 publications

(106 reference statements)

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“…Furthermore, administration of exosomes could represent an alternative therapy for AD (Fang et al 2018;El Andaloussi et al 2013). Intravenous administration of MSC-derived exosomes enhances functional recovery in stroke-induced rats (Bang et al 2016); this might be attributed to "miR delivery to target cells," thereby regulating the expression of genetic information and promoting a therapeutic response (Juranek et al 2013). For instance, MSC transplantation raised miR-133b expression in the brains of stroke-induced rats and regulated neurite outgrowth (Xin et al 2012).…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

“…Recently, three-dimensional (3D) modeling aimed to simulate the in vivo-like microenvironment of the stem cells, to preserve their characteristics and to enhance their mechanism of action (Sart et al 2014;Frith et al 2010); this approach could assist the clinical application of stem cells (Bang et al 2016). For example, "3D MSCs" expresses higher neuromodulating factors (Frith et al 2010); thereby this type of MSCs could present a higher therapeutic potential.…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

“…MSC transplantation into elder stroke-patients, who already have a limited content of NSCs/NPCs and BM-MSCs, will be of no significance because of loss of regenerative capacity of MSCs (Bang et al 2016). This attenuation of the potential of stem cell-based therapy in aged patients could result from aging in either the donor cells or the host cells (Manganas et al 2007).…”

Section: Time Of Transplantationmentioning

confidence: 99%

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Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of amyloid plaques and neurofibrillary tangles. Approved medications provide only symptomatic relief without affecting AD progression. Because of the multifactorial nature of AD and the absence of effective treatment, stem cell-based therapy has been regarded as an effective, safe, and innovative therapeutic approach to overcome AD. Different sources of stem cells are employed for AD treatment, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). There is a growing body of evidence supporting the promising therapeutic potential of stem cell transplantation, which might be attributed to the mechanistic actions exerted by stem cells such as inducing hippocampal neurogenesis, secreting paracrine factors, exerting anti-inflammatory activity, showing anti-amyloidogenic potential, and finally resulting in cognitive recovery. Although stem cell-based therapy faces potential hurdles, it holds a potential hope to provide a safe, effective, and feasible clinical application of stem cells in AD patients.

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Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Section: Time Of Transplantationmentioning

confidence: 99%

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Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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“…Recently, there have been significant advances in overcoming the limitations of current stem cell therapies including advances in biotechnology and the cell-free paradigm [53,54].…”

Section: Recent Advances and Guidelinesmentioning

confidence: 99%

Stem cell therapy for stroke: lessons learned from recent successful randomized trials of interventional therapy for stroke

Bang

2018

Precis Future Med

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Cell-based therapy is a promising approach for treating acute stroke patients as well as those with fixed neurological deficits, and therefore, the number of stem cell trials conducted on stroke patients is increasing. However, more studies are needed to conclude the efficacy of stem cell therapy because while several studies showed a beneficial effect, there was significant bias in subsequent studies. Meanwhile, there have been recent advances in stroke treatment such as endovascular therapy for acute ischemic stroke and catheter-based closing of a patent foramen ovale in cryptogenic stroke. Clinical trials of the latter two interventional therapies have very similar histories of consistent success after repeated failures. In this review, the factors related to the success of these interventional therapies are discussed and applied to stem cell therapy for stroke patients. Through continued efforts, there is hope for success in stem cell therapy for stroke patients.

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“…Loss of proliferative capacity under standard culture conditions as well as the method for the delivery of adult stem cells to the patient may impact on their ability to survive posttransplantation [35,36].…”

mentioning

confidence: 99%

The Proangiogenic Potential of Mesenchymal Stem Cells and Their Therapeutic Applications

Bandara¹,

Lim

Chen

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Mesenchymal stem cells (MSCs) can be isolated from many tissue types and following in vitro culture expansion, large numbers of patient-specific or allogenic cells can be produced for clinical applications. MSCs exhibit anti-inflammatory and immunomodulatory properties and are identified as lacking major histocompatibility complex (MHC) class II molecules. Cellular-based approaches using MSCs to enhance new blood vessel formation have shown promise in preclinical models and preliminary clinical trials. Transplantation of MSCs in vivo has significantly enhanced the formation of new blood vessels and promoted the healing of chronic wounds. The proangiogenic potential of MSCs can be further enhanced through gene delivery such as vascular endothelial growth factor (VEGF) or endothelial nitric oxide synthase (eNOS) providing long-term therapeutic expression. In this chapter, we review recent advances on the isolation and characterization of MSCs and in vivo applications for promoting angiogenesis. Enhancement of angiogenesis is also required for improved healing in myocardial infarction and cerebral ischemia, and the use of MSCs in these areas will also be reviewed. Furthermore, the combination of MSCs with biomaterials has greatly improved their survival and potency with improved vascularization of tissue-engineered constructs and integration within the host. In summary, this chapter provides an overview of both the basic science supporting the proangiogenic properties of MSCs and their translational use.

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Adult Stem Cell Therapy for Stroke: Challenges and Progress

Cited by 93 publications

References 111 publications

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Stem cell therapy for stroke: lessons learned from recent successful randomized trials of interventional therapy for stroke

The Proangiogenic Potential of Mesenchymal Stem Cells and Their Therapeutic Applications

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