Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence

Bond, Kamila M.; Hughes, Joshua D.; Porter, Amanda; Orina, Josiah N.; Fang, Shanna; Parney, Ian F.

doi:10.1016/j.wneu.2017.11.102

Cited by 44 publications

(33 citation statements)

References 44 publications

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“…Overall, as in our cohort, previous reports describe the mean age of adult pilocytic astrocytoma diagnosis to be in the late 20 s-early 30 s, with localization primarily in the cerebellum and/or brainstem [14][15][16][17][18], with signs and symptoms of raised ICP due to the development of hydrocephalus present in up to 90% in certain reports [16]. Gross total resection has been achieved in approximately 50% of cases in the most modern series [14], comparable to our findings. However, the reported 7% permanent postoperative deficits are markedly lower than in our cohort (19.2%), however there is a difference in reporting where Kamila et alonly reported on permanent deficits [14].…”

Section: Pilocytic Astrocytomasupporting

confidence: 90%

“…Gross total resection has been achieved in approximately 50% of cases in the most modern series [14], comparable to our findings. However, the reported 7% permanent postoperative deficits are markedly lower than in our cohort (19.2%), however there is a difference in reporting where Kamila et alonly reported on permanent deficits [14]. Of note, earlier series by Ye et al [15] reported up to 20% morbidity, 35% complication frequency and a 10% mortality, which are all higher than numbers reported in our cohort and a possible indication of improvement in surgical care over time.…”

Section: Pilocytic Astrocytomasupporting

confidence: 90%

“…Treatment outcomes in adult PA has been reported on previously [14][15][16][17][18], albeit mainly with focus on the overall treatment outcome and risk of recurrence rather than surgical morbidity and mortality. Overall, as in our cohort, previous reports describe the mean age of adult pilocytic astrocytoma diagnosis to be in the late 20 s-early 30 s, with localization primarily in the cerebellum and/or brainstem [14][15][16][17][18], with signs and symptoms of raised ICP due to the development of hydrocephalus present in up to 90% in certain reports [16]. Gross total resection has been achieved in approximately 50% of cases in the most modern series [14], comparable to our findings.…”

Section: Pilocytic Astrocytomamentioning

confidence: 99%

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Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database

et al. 2020

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Objective To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR). Methods This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009-2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). We analyzed symptomatology, tumor characteristics and outcomes.

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Section: Pilocytic Astrocytomasupporting

confidence: 90%

Section: Pilocytic Astrocytomasupporting

confidence: 90%

Section: Pilocytic Astrocytomamentioning

confidence: 99%

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Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database

et al. 2020

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“…Pilocytic astrocytomas are low-grade gliomas most commonly seen in childhood and can be cured with complete surgical resection. In adults, they can present as adult pilocytic astrocytomas or reflect a recurrent tumor after an incomplete surgical resection at an early age [18]. Pilocytic astrocytoma demonstrates a myxoid background and numerous monomorphous bipolar cells, whose processes often radiate from prominent blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Septum Pellucidum Chronic Encapsulated Hematoma With Osseous Metaplasia Mimicking Recurrent Astrocytoma and Shunt-Related Foreign Body Granuloma

Roberti

Bell

2020

Cureus

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We present a very rare case of chronic encapsulated intracerebral hematoma involving the septum pellucidum and the foramen of Monro that by location radiological appearance, and clinical history was mimicking a recurrent astrocytoma or a shunt-related foreign body granuloma. A young adult underwent the resection of a juvenile pilocytic astrocytoma as a child, and with a mass encasing the tip of an old non-functioning ventricular catheter, the differential diagnosis of shunt-related foreign body granuloma versus recurrent low-grade glioma was raised. Although chronic encapsulated intracerebral hematomas have been reported in the literature, the anatomical location of the lesion in the presented case was unique, with radiological and history findings also posing a peculiar diagnostic challenge. Chronic encapsulated intracerebral hematomas are benign entities that may also be found to involve deep and midline supratentorial structures usually not prone to spontaneous intraparenchymal hemorrhages. When symptomatic, surgical resection of the hematoma can be both diagnostic and curative.

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“…Pilocytic astrocytoma (PA) is a World Health Organization (WHO) grade I tumor, accounting for approximately 25% of pediatric brain tumor patients and 1.5% of adult brain tumor patients with the incidence rate of 4.8 per million per year; these cancers occasionally affect the spinal cord (1). PA is generally considered to be a slow-growing, wellcircumscribed lesion, often containing cystic areas that can be surgically curable after a gross total resection (2,3).…”

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confidence: 99%

The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma

Martinelli

Gabriele

Manai

et al. 2020

Cancer Genomics Proteomics

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Background/Aim: We herein presented a case of pediatric spinal cord pilocytic astrocytoma diagnosed on the basis of histopathological and clinical findings. Materials and Methods: Given the paucity of data on genetic features for this tumor, we performed exome, array CGH and RNA sequencing analysis from nucleic acids isolated from a unique and not repeatable very small amount of a formalinfixed, paraffin-embedded (FFPE) specimen. Results: DNA mutation analysis, comparing tumor and normal lymphocyte peripheral DNA, evidenced few tumor-specific single nucleotide variants in DEFB119, MUC5B, NUDT1, LTBP3 and CPSF3L genes. Differently, tumor DNA was not characterized by for the main pilocytic astrocytoma gene variations, including BRAFV600E. An inframe trinucleotides insertion involving DLX6 or lnc DLX6-AS1 genes was scored in 44.9% of sequenced reads; the temporal profile of this variation on the expression of DLX-AS1 was investigated in patient`s urine-derived exosomes, reporting no significant variation in the one-year molecular follow-up. Array CGH identified a tumor microdeletion at the 6q25.3 chromosomal region, spanning 1,01 Mb and comprising ZDHHC14, SNX9, TULP4 and SYTL3 genes. The expression of these genes did not change in urine-derived exosomes during the one-year investigation period. Finally, RNAseq did not reveal any of the common pilocytic BRAF-KIAA1549 genes fusion events. Conclusion: To our knowledge, the present report is one of the first described gene-orphan case studies of a pediatric spinal cord pilocytic astrocytoma.

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Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence

Cited by 44 publications

References 44 publications

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database

Septum Pellucidum Chronic Encapsulated Hematoma With Osseous Metaplasia Mimicking Recurrent Astrocytoma and Shunt-Related Foreign Body Granuloma

The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma

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