Adult-onset Still’s disease triggered by pregnancy

Abstract

Adult-onset Still's disease (AOSD) is an inflammatory disorder with arthritis, quotidian fever, evanescent rash, elevated white cell count, elevated ferritin, and abnormal liver function tests. The diagnosis requires the exclusion of other inflammatory, infectious, and malignant conditions. Onset of AOSD, though rare, has been known to occur in pregnancy. We present a 28-year-old woman diagnosed with AOSD at 3 months gestation.

Adult-onset Still's Disease during Pregnancy Treated with Tocilizumab

“…In addition, cases of AOSD in which the onset occurs during the perinatal period are rare. A summary of reported cases of AOSD from 1971 onwards in which the onset occurred during the perinatal period is shown in Table (13,14,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Of the 22 patients, including the present patient, 20 (90.9%) were treated with corticosteroids.…”

“…In addition, some cases involving pregnant women have been reported. Although the relationship between AOSD and pregnancy is unclear, it is rare for AOSD to first arise during pregnancy (13,14). Although most patients who develop AOSD during pregnancy are treated with corticosteroids, there have not been any case reports about such patients being treated with TCZ.…”

Targeted treatment challenges in patients with adult-onset Still’s disease

“…Кувардин. Существуют данные о возможности развития БСВ во время беременности, однако их взаимосвязь остается до конца неясной [19,20]. А. Ida и соавт.…”