Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus in a Mother and Her Daughter

Goldman, K.P.; Don, Philip C.

doi:10.1159/000246825

Cited by 34 publications

(23 citation statements)

References 9 publications

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“…In general, ILVEN is considered to represent a sporadic disease although there are several reports of familial occurrence [2, 22, 23, 24, 25](fig. 3).…”

Section: Possible Examples Of Blaschko Linear Skin Disorders Visualizmentioning

confidence: 99%

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Transposable Elements and the Lines of Blaschko: A New Perspective

Happle¹

2002

Dermatology

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Background: Transposable elements or retrotransposons are particles of retroviral origin that are interspersed in large numbers in the genome of plants and animals. They may affect the activity of adjacent genes by methylation or demethylation, resulting in silencing or activation of gene expression. In animals such as mice or dogs, retrotransposons may give rise to phenotypic variation in the form of variegated coat patterns reminiscent of the lines of Blaschko as observed in human skin. Objective and Methods: Because the human genome does likewise contain large amounts of retrotransposons, it is conceivable that these elements may cause similar skin lesions in human skin. The group of genodermatoses following the lines of Blaschko was therefore screened for phenotypes suggesting such an epigenetic origin. Results: As possible examples, the inflammatory linear verrucous epidermal nevus as well as cases of pigmentary mosaicism arranged in hypermelanotic or hypomelanotic streaks following the lines of Blaschko may be taken into consideration. Such phenotypes usually occur sporadically but may affect, by way of exception, several members of a family. Conclusion: These linear skin disorders would possibly visualize the action of a transposable element that is partly expressed and partly silenced at an early developmental stage.

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“…In general, ILVEN is considered to represent a sporadic disease although there are several reports of familial occurrence [2, 22, 23, 24, 25](fig. 3).…”

Section: Possible Examples Of Blaschko Linear Skin Disorders Visualizmentioning

confidence: 99%

“…This concept would explain why ILVEN virtually always occurs sporadically, and why the exceptional familial cases do not show a uniform mendelian pattern but tend to imitate an autosomal dominant [2, 22, 23, 24]or recessive [25]mode of transmission.…”

Section: Possible Examples Of Blaschko Linear Skin Disorders Visualizmentioning

confidence: 99%

Transposable Elements and the Lines of Blaschko: A New Perspective

Happle¹

2002

Dermatology

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“…In other atypical ILVEN, a generalized form (6,7) and familial occurrence (6--8) are also reported. Goldman et al (6) reported mother and daughter cases of ILVEN; their onset was nearly simultaneous. The daughter's generalized eruption involved 70% of her body, including the face, chest, back, arms and legs.…”

Section: Discussionmentioning

confidence: 91%

Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus

Kawaguchi

Takeuchi

Ono

et al. 1999

The Journal of Dermatology

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Adult onset of inflammatory linear verrucous epidermal nevus (ILVEN) is reported in a 44-year-old Japanese man. A mild pruritic eruption appeared one year earlier and extended from the left dorsal foot to the gluteal region. Histologically, acanthosis and papillomatous thickening of epidermis as well as spongiotic edema and exocytosis with lymphocytes and neutrophils were observed. Topical tacalcitol was not effective, but the pruritus as well as the eruption slightly improved with topical corticosteroid and vaseline containing salicylic acid. This adult onset of ILVEN is considered to be a rare case.

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“…Interestingly, except for the few reports of familial ILVEN [15,16,17,18] no further comments supporting the possibility for a heritability of ILVEN to the offspring exist. In 2002, Happle [37] hypothesized that a transposable element, which is partly activating and partly silencing a neighboring gene by demethylation or methylation at an early developmental stage, could be responsible for the development of ILVEN.…”

Section: Discussionmentioning

confidence: 99%

“…ILVEN occurs sporadically. Familial cases are extremely rare [15,16,17,18]. Therefore ILVEN, similar to other nevi, is thought to be the result of a new and early postzygotic mutation reflecting genetic mosaicism [12].…”

Section: Discussionmentioning

confidence: 99%

Does Inflammatory Linear Verrucous Epidermal Nevus Represent a Segmental Type 1/Type 2 Mosaic of Psoriasis?

Hofer¹

2006

Dermatology

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Background: A 6-year-old girl with a symmetric linear eruption on both of her legs, clinically and histologically resembling inflammatory linear verrucous epidermal nevus (ILVEN) or linear psoriasis (LP), with concomitant psoriasis of the guttata type and a positive family history of psoriasis is presented. The questions as to whether LP actually exists and ILVEN represents a distinct entity are still under debate. Objective and Methods: The recent literature concerning case reports of ILVEN and LP is reviewed. Results: Case reports of ILVEN and LP can be subdivided into four different groups: (1) ILVEN with or without concomitant psoriasis, only in part reacting to antipsoriatic treatment, (2) ILVEN without concomitant psoriasis, (3) LP with concomitant psoriasis vulgaris, with both groups 2 and 3 reacting successfully to antipsoriatic treatment, and (4) LP without concomitant psoriasis vulgaris and with no family history of psoriasis (very rarely reported). Conclusion: It is hypothesized that inflammatory linear verrucous eruption besides nevoid psoriasis/LP represents a further segmental type 1/type 2 mosaic of psoriasis which, if a (verrucous) epidermal nevus exists, shows a high affinity of occurrence in close context to such a nevus. Heritability is thought to be possible.

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Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus in a Mother and Her Daughter

Cited by 34 publications

References 9 publications

Transposable Elements and the Lines of Blaschko: A New Perspective

Transposable Elements and the Lines of Blaschko: A New Perspective

Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus

Does Inflammatory Linear Verrucous Epidermal Nevus Represent a Segmental Type 1/Type 2 Mosaic of Psoriasis?

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