Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: Accuracy of five different methods of height prediction

Brämswig, Jürgen; Fasse, M.; Holthoff, M.-L.; Lengerke, H.-J. Von; Petrykowski, W. v.; Schellong, G.

doi:10.1016/s0022-3476(05)80127-1

Cited by 112 publications

(90 citation statements)

References 18 publications

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“…Subjects with CDGP have previously been shown to achieve FH that is normal or lower-range normal compared with the general population, with values ranging from –1.9 to –0.6 SDs [5,6,7,8,9,10, 12]. However, not all boys with CDGP reach their genetic TH [7, 9, 10, 13].…”

Section: Discussionmentioning

confidence: 99%

“…At least in a subgroup of CDGP subjects, the reduction in height SDs starts already early in childhood, well before puberty [4, 5]. Although boys with CDGP may be short during pubertal years, many will achieve a final adult height (FH) that is normal compared with the general population [5,6,7,8,9]. However, some subjects with CDGP have been shown to attain a FH that is significantly (>0.8 SDs) below their genetic target height (TH) [7,10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Although boys with CDGP may be short during pubertal years, many will achieve a final adult height (FH) that is normal compared with the general population [5,6,7,8,9]. However, some subjects with CDGP have been shown to attain a FH that is significantly (>0.8 SDs) below their genetic target height (TH) [7,10,11,12,13]. In one study, 58% of subjects with CDGP attained a FH that was 1.5 SDs below their target [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Progressive Reduction of Relative Height in Childhood Predicts Adult Stature below Target Height in Boys with Constitutional Delay of Growth and Puberty

Wehkalampi

Vangonen²,

Laine³

et al. 2007

Horm Res Paediatr

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Background/Aims: In some adolescents with constitutional delay of growth and puberty (CDGP), the reduction in relative height (height SDs) starts already in childhood, before puberty. Some subjects with CDGP do not reach their target height (TH). We investigated whether early height SD reduction or testosterone treatment in low doses (1–2 mg/kg/month) influence final height (FH). Methods: The growth of 70 adult men with a history of CDGP was investigated. 31 subjects (13 treated with testosterone) had progressive height SD reduction between 3 and 9 years, and in 39 (17 treated with testosterone) no such reduction was seen. Results: In untreated subjects without early height SD reduction, FH was closer to TH than in those with such reduction (FH – TH 0.05 ± 0.94 vs. –0.63 ± 0.50 SD, p = 0.009). FH – TH did not differ between the testosterone-treated and untreated subjects in the group with early height SD reduction (FH – TH –0.36 ± 0.48 vs. –0.63 ± 0.50 SD, p = 0.15), nor in the group without such reduction (FH – TH –0.08 ± 0.70 vs. 0.05 ± 0.94 SD, p = 0.64). Conclusion: Subjects with early height SD reduction do not attain FH consistent with their genetic height potential, whereas those without such reduction do. Treatment with low doses of testosterone does not adversely affect FH.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Progressive Reduction of Relative Height in Childhood Predicts Adult Stature below Target Height in Boys with Constitutional Delay of Growth and Puberty

Wehkalampi

Vangonen²,

Laine³

et al. 2007

Horm Res Paediatr

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“…Brämswig et al 28 alerted to the importance of observing the tendency of each method to over-or underestimate final height and to the wide individual variations of the estimates, especially considering if the patients receive or not treatment for the promotion of growth 28 .…”

Section: Methodsmentioning

confidence: 99%

Comparison of methods for final height assessment in adolescents with a normal variant short stature

Costa

Tomita

Barbieri

et al. 2017

J. Hum. Growth Dev.

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“…There have been numerous comparisons of the various methods of predicting height for different conditions such as constitutional tall stature, hypothyroidism, constitutional short stature, and achondroplasia [4,5,7]. The present study is the only one to use these methods for patients who had limb salvage surgery for primary bone tumors.…”

Section: How Do We Get There?mentioning

confidence: 99%

CORR Insights®: Paley's Multiplier Method Does Not Accurately Predict Adult Height in Children with Bone Sarcoma

Song

2014

Clinical Orthopaedics &Amp; Related Research

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Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: Accuracy of five different methods of height prediction

Cited by 112 publications

References 18 publications

Progressive Reduction of Relative Height in Childhood Predicts Adult Stature below Target Height in Boys with Constitutional Delay of Growth and Puberty

Progressive Reduction of Relative Height in Childhood Predicts Adult Stature below Target Height in Boys with Constitutional Delay of Growth and Puberty

Comparison of methods for final height assessment in adolescents with a normal variant short stature

CORR Insights®: Paley's Multiplier Method Does Not Accurately Predict Adult Height in Children with Bone Sarcoma

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